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Enzyme Kinetics, Pharmacokinetics, and Inhibition of Aldehyde Oxidase.

Paragas EM, Choughule K, Jones JP, Barr JT. Paragas EM, et al. Methods Mol Biol. 2021;2342:257-284. doi: 10.1007/978-1-0716-1554-6_10. Methods Mol Biol. 2021. PMID: 34272698

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Aldehyde Oxidase Contributes to All-Trans-Retinoic Acid Biosynthesis in Human Liver.

Zhong G, Seaman CJ, Paragas EM, Xi H, Herpoldt KL, King NP, Jones JP, Isoherranen N. Zhong G, et al. Among authors: paragas em. Drug Metab Dispos. 2021 Mar;49(3):202-211. doi: 10.1124/dmd.120.000296. Epub 2020 Dec 18. Drug Metab Dispos. 2021. PMID: 33355213 Free PMC article.

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Time Course of Aldehyde Oxidase and Why It Is Nonlinear.

Abbasi A, Paragas EM, Joswig-Jones CA, Rodgers JT, Jones JP. Abbasi A, et al. Among authors: paragas em. Drug Metab Dispos. 2019 May;47(5):473-483. doi: 10.1124/dmd.118.085787. Epub 2019 Feb 20. Drug Metab Dispos. 2019. PMID: 30787100 Free PMC article.

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Complex Cytochrome P450 Kinetics Due to Multisubstrate Binding and Sequential Metabolism. Part 1. Theoretical Considerations.

Wang Z, Paragas EM, Nagar S, Korzekwa K. Wang Z, et al. Among authors: paragas em. Drug Metab Dispos. 2021 Dec;49(12):1090-1099. doi: 10.1124/dmd.121.000553. Epub 2021 Sep 9. Drug Metab Dispos. 2021. PMID: 34503952

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Antitubercular constituents from Premna odorata Blanco.

Lirio SB, Macabeo AP, Paragas EM, Knorn M, Kohls P, Franzblau SG, Wang Y, Aguinaldo MA. Lirio SB, et al. Among authors: paragas em. J Ethnopharmacol. 2014 Jun 11;154(2):471-4. doi: 10.1016/j.jep.2014.04.015. Epub 2014 Apr 23. J Ethnopharmacol. 2014. PMID: 24768632

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Complex Cytochrome P450 Kinetics Due to Multisubstrate Binding and Sequential Metabolism. Part 2. Modeling of Experimental Data.

Paragas EM, Wang Z, Korzekwa K, Nagar S. Paragas EM, et al. Drug Metab Dispos. 2021 Dec;49(12):1100-1108. doi: 10.1124/dmd.121.000554. Epub 2021 Sep 9. Drug Metab Dispos. 2021. PMID: 34503953

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The two faces of aldehyde oxidase: Oxidative and reductive transformations of 5-nitroquinoline.

Paragas EM, Humphreys SC, Min J, Joswig-Jones CA, Jones JP. Paragas EM, et al. Biochem Pharmacol. 2017 Dec 1;145:210-217. doi: 10.1016/j.bcp.2017.09.002. Epub 2017 Sep 6. Biochem Pharmacol. 2017. PMID: 28888950

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Kinetic mechanism of time-dependent inhibition of CYP2D6 by 3,4-methylenedioxymethamphetamine (MDMA): Functional heterogeneity of the enzyme and the reversibility of its inactivation.

Rodgers JT, Davydova NY, Paragas EM, Jones JP, Davydov DR. Rodgers JT, et al. Among authors: paragas em. Biochem Pharmacol. 2018 Oct;156:86-98. doi: 10.1016/j.bcp.2018.08.010. Epub 2018 Aug 13. Biochem Pharmacol. 2018. PMID: 30114388 Free PMC article.

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ecoAO: A Simple System for the Study of Human Aldehyde Oxidases Role in Drug Metabolism.

Paragas EM, Humphreys SC, Min J, Joswig-Jones CA, Leimkühler S, Jones JP. Paragas EM, et al. ACS Omega. 2017 Aug 31;2(8):4820-4827. doi: 10.1021/acsomega.7b01054. Epub 2017 Aug 22. ACS Omega. 2017. PMID: 28884164 Free PMC article.

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One-pot SSA-catalyzed β-elimination: an efficient and inexpensive protocol for easy access to the glycal of sialic acid.

Paragas EM, Monreal IA, Vasil CM, Saludes JP. Paragas EM, et al. Carbohydr Res. 2015 Jan 30;402:77-80. doi: 10.1016/j.carres.2014.09.002. Epub 2014 Sep 17. Carbohydr Res. 2015. PMID: 25497336 Free PMC article.

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