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157 results

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Page 1
PARP14 inhibits microglial activation via LPAR5 to promote post-stroke functional recovery.
Tang Y, Liu J, Wang Y, Yang L, Han B, Zhang Y, Bai Y, Shen L, Li M, Jiang T, Ye Q, Yu X, Huang R, Zhang Z, Xu Y, Yao H. Tang Y, et al. Autophagy. 2021 Oct;17(10):2905-2922. doi: 10.1080/15548627.2020.1847799. Epub 2020 Dec 15. Autophagy. 2021. PMID: 33317392 Free PMC article.
Genetic knockdown and pharmacological inhibition of PARP14 aggravated functional impairment and increased infarct volume in PT mice, while overexpression of PARP14 displayed the opposite effects. Furthermore, PARP14 was abundant in microglia, and downregulati …
Genetic knockdown and pharmacological inhibition of PARP14 aggravated functional impairment and increased infarct volume in PT mice, …
PARP14 and PARP9/DTX3L regulate interferon-induced ADP-ribosylation.
Kar P, Chatrin C, Đukić N, Suyari O, Schuller M, Zhu K, Prokhorova E, Bigot N, Baretić D, Ahel J, Elsborg JD, Nielsen ML, Clausen T, Huet S, Niepel M, Sanyal S, Ahel D, Smith R, Ahel I. Kar P, et al. EMBO J. 2024 Jul;43(14):2929-2953. doi: 10.1038/s44318-024-00126-0. Epub 2024 Jun 4. EMBO J. 2024. PMID: 38834853 Free PMC article.
We visualised endogenous interferon (IFN)-induced ADP-ribosylation and show that PARP14 is a major enzyme responsible for this modification. Fittingly, this signalling is reversed by the macrodomain from SARS-CoV-2 (Mac1), providing a possible mechanism by which Mac1 count …
We visualised endogenous interferon (IFN)-induced ADP-ribosylation and show that PARP14 is a major enzyme responsible for this modifi …
PARP14 is a PARP with both ADP-ribosyl transferase and hydrolase activities.
Đukić N, Strømland Ø, Elsborg JD, Munnur D, Zhu K, Schuller M, Chatrin C, Kar P, Duma L, Suyari O, Rack JGM, Baretić D, Crudgington DRK, Groslambert J, Fowler G, Wijngaarden S, Prokhorova E, Rehwinkel J, Schüler H, Filippov DV, Sanyal S, Ahel D, Nielsen ML, Smith R, Ahel I. Đukić N, et al. Sci Adv. 2023 Sep 15;9(37):eadi2687. doi: 10.1126/sciadv.adi2687. Epub 2023 Sep 13. Sci Adv. 2023. PMID: 37703374 Free PMC article.
However, little is known about the ADP-ribosylation activity of PARP14, including its substrate specificity or how PARP14-dependent ADP-ribosylation is reversed. ...We reveal that expression of a PARP14 mutant with the inactivated macrodomain 1 results in a m …
However, little is known about the ADP-ribosylation activity of PARP14, including its substrate specificity or how PARP14-depe …
PARP14 inhibition restores PD-1 immune checkpoint inhibitor response following IFNgamma-driven acquired resistance in preclinical cancer models.
Wong CW, Evangelou C, Sefton KN, Leshem R, Zhang W, Gopalan V, Chattrakarn S, Fernandez Carro ML, Uzuner E, Mole H, Wilcock DJ, Smith MP, Sergiou K, Telfer BA, Isaac DT, Liu C, Perl NR, Marie K, Lorigan P, Williams KJ, Rao PE, Nagaraju RT, Niepel M, Hurlstone AFL. Wong CW, et al. Nat Commun. 2023 Sep 26;14(1):5983. doi: 10.1038/s41467-023-41737-1. Nat Commun. 2023. PMID: 37752135 Free PMC article.
We observe upregulation of poly-ADP ribosyl polymerase 14 (PARP14) in chronic IFNgamma-treated cancer cell models, in patient melanoma with elevated IFNG expression, and in melanoma cell cultures from ICBT-progressing lesions characterised by elevated IFNgamma signalling. …
We observe upregulation of poly-ADP ribosyl polymerase 14 (PARP14) in chronic IFNgamma-treated cancer cell models, in patient melanom …
The connection between PARP14 and SARS-CoV-2.
L Tauber A, S Schweiker S, M Levonis S. L Tauber A, et al. Future Med Chem. 2023 Feb;15(3):225-227. doi: 10.4155/fmc-2023-0013. Epub 2023 Feb 3. Future Med Chem. 2023. PMID: 36734263 No abstract available.
Recent developments in PARP14 research.
Tauber AL, Levonis SM, Schweiker SS. Tauber AL, et al. Future Med Chem. 2020 Sep;12(18):1657-1667. doi: 10.4155/fmc-2020-0166. Epub 2020 Sep 7. Future Med Chem. 2020. PMID: 32893678 Review.
This review aims to reflect upon the major developments in PARP14 research from late 2017 to early 2020. In doing so, this report will focus on the continual elucidation of PARP14's function including an emerging role in viral replication. ...This report will also i …
This review aims to reflect upon the major developments in PARP14 research from late 2017 to early 2020. In doing so, this report wil …
PARP14 is regulated by the PARP9/DTX3L complex and promotes interferon gamma-induced ADP-ribosylation.
Ribeiro VC, Russo LC, Hoch NC. Ribeiro VC, et al. EMBO J. 2024 Jul;43(14):2908-2928. doi: 10.1038/s44318-024-00125-1. Epub 2024 Jun 4. EMBO J. 2024. PMID: 38834852 Free PMC article.
Here we show that host ADP-ribosyltransferase activity induced by IFNgamma signalling depends on PARP14 catalytic activity and that the PARP9/DTX3L complex is required to uphold PARP14 protein levels via post-translational mechanisms. Both the PARP9/DTX3L complex an …
Here we show that host ADP-ribosyltransferase activity induced by IFNgamma signalling depends on PARP14 catalytic activity and that t …
PARP14 Contributes to the Development of the Tumor-Associated Macrophage Phenotype.
Sturniolo I, Váróczy C, Regdon Z, Mázló A, Muzsai S, Bácsi A, Intili G, Hegedűs C, Boothby MR, Holechek J, Ferraris D, Schüler H, Virág L. Sturniolo I, et al. Int J Mol Sci. 2024 Mar 22;25(7):3601. doi: 10.3390/ijms25073601. Int J Mol Sci. 2024. PMID: 38612413 Free PMC article.
Here, we show that the multispectral PARP inhibitor (PARPi) PJ34 and the PARP14 specific inhibitor MCD113 suppress the expression of M2 marker genes in IL-4-polarized primary murine Mphis, in THP-1 monocytic human Mphis, and in primary human monocyte-derived Mphis. Mphis i …
Here, we show that the multispectral PARP inhibitor (PARPi) PJ34 and the PARP14 specific inhibitor MCD113 suppress the expression of …
Targeting PARP14 with lomitapide suppresses drug resistance through the activation of DRP1-induced mitophagy in multiple myeloma.
Zhang H, Wang H, Hu Y, Gao Y, Chen J, Meng Y, Qiu Y, Hu R, Liao P, Li M, He Y, Liang Z, Xie X, Li Y. Zhang H, et al. Cancer Lett. 2024 Apr 28;588:216802. doi: 10.1016/j.canlet.2024.216802. Epub 2024 Mar 11. Cancer Lett. 2024. PMID: 38467180
Excessive mitophagy caused mitochondrial damage and dysfunction induced by lomitapide. Meanwhile, PARP14 was identified as a direct target of lomitapide by SPR-HPLC-MS, and we showed that DRP1-induced mitophagy was crucial in the anti-MM activity mediated by PARP14. …
Excessive mitophagy caused mitochondrial damage and dysfunction induced by lomitapide. Meanwhile, PARP14 was identified as a direct t …
PARP14 is a writer, reader, and eraser of mono-ADP-ribosylation.
Torretta A, Chatzicharalampous C, Ebenwaldner C, Schüler H. Torretta A, et al. J Biol Chem. 2023 Sep;299(9):105096. doi: 10.1016/j.jbc.2023.105096. Epub 2023 Jul 26. J Biol Chem. 2023. PMID: 37507011 Free PMC article.
PARP14/BAL2 is a large multidomain enzyme involved in signaling pathways with relevance to cancer, inflammation, and infection. ...PARP14 macrodomain-1 is unable to degrade poly(ADP-ribose), the enzymatic product of PARP1. ...
PARP14/BAL2 is a large multidomain enzyme involved in signaling pathways with relevance to cancer, inflammation, and infection. ... …
157 results