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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 2
1991 1
1992 5
1993 1
1994 2
1995 2
1996 2
1997 10
1998 7
1999 5
2000 8
2001 13
2002 7
2003 9
2004 4
2005 1
2006 4
2007 8
2008 13
2009 7
2010 8
2011 16
2012 15
2013 9
2014 10
2015 13
2016 20
2017 11
2018 4
2019 6
2020 7
2021 5
2022 6
2023 5
2024 1

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225 results

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Page 1
Bispecific antibodies: a mechanistic review of the pipeline.
Labrijn AF, Janmaat ML, Reichert JM, Parren PWHI. Labrijn AF, et al. Among authors: parren pwhi. Nat Rev Drug Discov. 2019 Aug;18(8):585-608. doi: 10.1038/s41573-019-0028-1. Nat Rev Drug Discov. 2019. PMID: 31175342 Review.
Gamma Delta T-Cell Based Cancer Immunotherapy: Past-Present-Future.
Saura-Esteller J, de Jong M, King LA, Ensing E, Winograd B, de Gruijl TD, Parren PWHI, van der Vliet HJ. Saura-Esteller J, et al. Among authors: parren pwhi. Front Immunol. 2022 Jun 16;13:915837. doi: 10.3389/fimmu.2022.915837. eCollection 2022. Front Immunol. 2022. PMID: 35784326 Free PMC article. Review.
Avidity in antibody effector functions and biotherapeutic drug design.
Oostindie SC, Lazar GA, Schuurman J, Parren PWHI. Oostindie SC, et al. Among authors: parren pwhi. Nat Rev Drug Discov. 2022 Oct;21(10):715-735. doi: 10.1038/s41573-022-00501-8. Epub 2022 Jul 5. Nat Rev Drug Discov. 2022. PMID: 35790857 Free PMC article. Review.
Discovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET.
Neijssen J, Cardoso RMF, Chevalier KM, Wiegman L, Valerius T, Anderson GM, Moores SL, Schuurman J, Parren PWHI, Strohl WR, Chiu ML. Neijssen J, et al. Among authors: parren pwhi. J Biol Chem. 2021 Jan-Jun;296:100641. doi: 10.1016/j.jbc.2021.100641. Epub 2021 Apr 8. J Biol Chem. 2021. PMID: 33839159 Free PMC article.
Celebrating Antibody Therapeutics.
Parren PWHI, Huston JS. Parren PWHI, et al. Protein Eng Des Sel. 2017 Sep 1;30(9):573. doi: 10.1093/protein/gzx053. Protein Eng Des Sel. 2017. PMID: 29088433 No abstract available.
DuoBody-CD3xCD20 induces potent T-cell-mediated killing of malignant B cells in preclinical models and provides opportunities for subcutaneous dosing.
Engelberts PJ, Hiemstra IH, de Jong B, Schuurhuis DH, Meesters J, Beltran Hernandez I, Oostindie SC, Neijssen J, van den Brink EN, Horbach GJ, Verploegen S, Labrijn AF, Salcedo T, Schuurman J, Parren PWHI, Breij ECW. Engelberts PJ, et al. Among authors: parren pwhi. EBioMedicine. 2020 Feb;52:102625. doi: 10.1016/j.ebiom.2019.102625. Epub 2020 Jan 23. EBioMedicine. 2020. PMID: 31981978 Free PMC article.
Complement is activated by IgG hexamers assembled at the cell surface.
Diebolder CA, Beurskens FJ, de Jong RN, Koning RI, Strumane K, Lindorfer MA, Voorhorst M, Ugurlar D, Rosati S, Heck AJ, van de Winkel JG, Wilson IA, Koster AJ, Taylor RP, Saphire EO, Burton DR, Schuurman J, Gros P, Parren PW. Diebolder CA, et al. Among authors: parren pw. Science. 2014 Mar 14;343(6176):1260-3. doi: 10.1126/science.1248943. Science. 2014. PMID: 24626930 Free PMC article.
A Bispecific γδ T-cell Engager Targeting EGFR Activates a Potent Vγ9Vδ2 T cell-Mediated Immune Response against EGFR-Expressing Tumors.
King LA, Toffoli EC, Veth M, Iglesias-Guimarais V, Slot MC, Amsen D, van de Ven R, Derks S, Fransen MF, Tuynman JB, Riedl T, Roovers RC, Adang AEP, Ruben JM, Parren PWHI, de Gruijl TD, van der Vliet HJ. King LA, et al. Among authors: parren pwhi. Cancer Immunol Res. 2023 Sep 1;11(9):1237-1252. doi: 10.1158/2326-6066.CIR-23-0189. Cancer Immunol Res. 2023. PMID: 37368791
Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange.
Labrijn AF, Meesters JI, de Goeij BE, van den Bremer ET, Neijssen J, van Kampen MD, Strumane K, Verploegen S, Kundu A, Gramer MJ, van Berkel PH, van de Winkel JG, Schuurman J, Parren PW. Labrijn AF, et al. Among authors: parren pw. Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5145-50. doi: 10.1073/pnas.1220145110. Epub 2013 Mar 11. Proc Natl Acad Sci U S A. 2013. PMID: 23479652 Free PMC article.
A Novel Bispecific Antibody Targeting EGFR and cMet Is Effective against EGFR Inhibitor-Resistant Lung Tumors.
Moores SL, Chiu ML, Bushey BS, Chevalier K, Luistro L, Dorn K, Brezski RJ, Haytko P, Kelly T, Wu SJ, Martin PL, Neijssen J, Parren PW, Schuurman J, Attar RM, Laquerre S, Lorenzi MV, Anderson GM. Moores SL, et al. Among authors: parren pw. Cancer Res. 2016 Jul 1;76(13):3942-53. doi: 10.1158/0008-5472.CAN-15-2833. Epub 2016 May 23. Cancer Res. 2016. PMID: 27216193
225 results