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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 1
2006 2
2007 1
2008 1
2009 3
2010 2
2011 2
2012 6
2013 12
2014 4
2015 6
2016 9
2017 5
2018 5
2019 7
2020 8
2021 6
2022 4
2023 7
2024 2

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79 results

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Page 1
Klotho, Aging, and the Failing Kidney.
Buchanan S, Combet E, Stenvinkel P, Shiels PG. Buchanan S, et al. Among authors: shiels pg. Front Endocrinol (Lausanne). 2020 Aug 27;11:560. doi: 10.3389/fendo.2020.00560. eCollection 2020. Front Endocrinol (Lausanne). 2020. PMID: 32982966 Free PMC article. Review.
Klotho has been recognized as a gene involved in the aging process in mammals for over 30 years, where it regulates phosphate homeostasis and the activity of members of the fibroblast growth factor (FGF) family. ...All these approaches have significant potential to mitigat …
Klotho has been recognized as a gene involved in the aging process in mammals for over 30 years, where it regulates phosphate homeost …
Ageing - Oxidative stress, PTMs and disease.
Ebert T, Tran N, Schurgers L, Stenvinkel P, Shiels PG. Ebert T, et al. Among authors: shiels pg. Mol Aspects Med. 2022 Aug;86:101099. doi: 10.1016/j.mam.2022.101099. Epub 2022 Jun 8. Mol Aspects Med. 2022. PMID: 35689974 Free article. Review.
Post-translational modifications (PTMs) have been proposed as a link between the oxidative stress-inflammation-ageing trinity, thereby affecting several hallmarks of ageing. Phosphorylation, acetylation, and ubiquitination cover >90% of all the reported PTMs. ... …
Post-translational modifications (PTMs) have been proposed as a link between the oxidative stress-inflammation-ageing trinity, thereb …
Inflammation and Premature Ageing in Chronic Kidney Disease.
Ebert T, Pawelzik SC, Witasp A, Arefin S, Hobson S, Kublickiene K, Shiels PG, Bäck M, Stenvinkel P. Ebert T, et al. Among authors: shiels pg. Toxins (Basel). 2020 Apr 4;12(4):227. doi: 10.3390/toxins12040227. Toxins (Basel). 2020. PMID: 32260373 Free PMC article. Review.
Persistent low-grade inflammation and premature ageing are hallmarks of the uremic phenotype and contribute to impaired health status, reduced quality of life, and premature mortality in chronic kidney disease (CKD). Because there is a huge global burden of disease due to …
Persistent low-grade inflammation and premature ageing are hallmarks of the uremic phenotype and contribute to impaired health status …
Telomere Homeostasis: Interplay with Magnesium.
Maguire D, Neytchev O, Talwar D, McMillan D, Shiels PG. Maguire D, et al. Among authors: shiels pg. Int J Mol Sci. 2018 Jan 5;19(1):157. doi: 10.3390/ijms19010157. Int J Mol Sci. 2018. PMID: 29303978 Free PMC article. Review.
Telomere biology, a key component of the hallmarks of ageing, offers insight into dysregulation of normative ageing processes that accompany age-related diseases such as cancer. Telomere homeostasis is tightly linked to cellular metabolism, and in particular with mi …
Telomere biology, a key component of the hallmarks of ageing, offers insight into dysregulation of normative ageing processes …
Extracellular Vesicles, Ageing, and Therapeutic Interventions.
Panagiotou N, Neytchev O, Selman C, Shiels PG. Panagiotou N, et al. Among authors: shiels pg. Cells. 2018 Aug 18;7(8):110. doi: 10.3390/cells7080110. Cells. 2018. PMID: 30126173 Free PMC article. Review.
Specifically, this employs their molecular payloads to confer changes in the epigenetic landscape of ageing cells and ameliorate the loss of functional capacity. Understanding the biology of extracellular vesicles and the specific roles they play during normative ageing
Specifically, this employs their molecular payloads to confer changes in the epigenetic landscape of ageing cells and ameliorate the …
The role of epigenetics in renal ageing.
Shiels PG, McGuinness D, Eriksson M, Kooman JP, Stenvinkel P. Shiels PG, et al. Nat Rev Nephrol. 2017 Aug;13(8):471-482. doi: 10.1038/nrneph.2017.78. Epub 2017 Jun 19. Nat Rev Nephrol. 2017. PMID: 28626222 Free article. Review.
An ability to separate natural ageing processes from processes specific to morbidities is required to understand the heterogeneity of age-related organ dysfunction. Mechanistic insight into how epigenetic factors regulate ageing throughout the life course, linked to …
An ability to separate natural ageing processes from processes specific to morbidities is required to understand the heterogeneity of …
Fabry Disease: A New Model of Premature Ageing?
Kooman JP, Stenvinkel P, Shiels PG. Kooman JP, et al. Among authors: shiels pg. Nephron. 2020;144(1):1-4. doi: 10.1159/000503290. Epub 2019 Sep 27. Nephron. 2020. PMID: 31563917 Free PMC article. No abstract available.
Chronic kidney disease and premature ageing.
Kooman JP, Kotanko P, Schols AM, Shiels PG, Stenvinkel P. Kooman JP, et al. Among authors: shiels pg. Nat Rev Nephrol. 2014 Dec;10(12):732-42. doi: 10.1038/nrneph.2014.185. Epub 2014 Oct 7. Nat Rev Nephrol. 2014. PMID: 25287433 Review.
We propose that in addition to a sedentary lifestyle and psychosocial and socioeconomic determinants, four major disease-induced mechanisms underlie premature ageing in CKD: an increase in allostatic load, activation of the 'stress resistance response', activation of age-p …
We propose that in addition to a sedentary lifestyle and psychosocial and socioeconomic determinants, four major disease-induced mechanisms …
Inflammation and premature aging in advanced chronic kidney disease.
Kooman JP, Dekker MJ, Usvyat LA, Kotanko P, van der Sande FM, Schalkwijk CG, Shiels PG, Stenvinkel P. Kooman JP, et al. Among authors: shiels pg. Am J Physiol Renal Physiol. 2017 Oct 1;313(4):F938-F950. doi: 10.1152/ajprenal.00256.2017. Epub 2017 Jul 12. Am J Physiol Renal Physiol. 2017. PMID: 28701312 Free article. Review.
Uremic inflammation is also mechanistically related to mechanisms involved in the aging process, such as telomere shortening, mitochondrial dysfunction, and altered nutrient sensing, which can have a direct effect on cellular and tissue function. ...In this review, the rel …
Uremic inflammation is also mechanistically related to mechanisms involved in the aging process, such as telomere shortening, mitocho …
Premature aging in chronic kidney disease and chronic obstructive pulmonary disease: similarities and differences.
Kooman JP, Shiels PG, Stenvinkel P. Kooman JP, et al. Among authors: shiels pg. Curr Opin Clin Nutr Metab Care. 2015 Nov;18(6):528-34. doi: 10.1097/MCO.0000000000000218. Curr Opin Clin Nutr Metab Care. 2015. PMID: 26372510 Review.
PURPOSE OF REVIEW: There is increasing clinical and pathophysiological evidence that a premature aging process is involved in the pathogenesis of systemic complications of many chronic organ diseases, which result in analogous phenotypes, including premature vascular ag
PURPOSE OF REVIEW: There is increasing clinical and pathophysiological evidence that a premature aging process is involved in the pat …
79 results