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Page 1
Protocadherin alpha 3 inhibits lung squamous cell carcinoma metastasis and epithelial-mesenchymal transition.
Tao Y, Fei L, Chang L, Yongyu L, Jianhui J, Yanan L, Yi R. Tao Y, et al. Genes Genomics. 2022 Feb;44(2):211-218. doi: 10.1007/s13258-021-01113-z. Epub 2021 Jun 4. Genes Genomics. 2022. PMID: 34086268
OBJECTIVE: To investigate the functional role of protocadherin alpha 3 (PCDHA3) in LUSC, as well as investigate the underlying molecular mechanism. METHODS: Data for PCDHA3 expression and clinical information in The Cancer Genome Atlas (TCGA) were extracted and anal …
OBJECTIVE: To investigate the functional role of protocadherin alpha 3 (PCDHA3) in LUSC, as well as investigate the underlying molecu …
LncRNA-ZXF1 stabilizes P21 expression in endometrioid endometrial carcinoma by inhibiting ubiquitination-mediated degradation and regulating the miR-378a-3p/PCDHA3 axis.
Kong D, Hou Y, Li W, Ma X, Jiang J. Kong D, et al. Mol Oncol. 2022 Feb;16(3):813-829. doi: 10.1002/1878-0261.12940. Epub 2021 Mar 22. Mol Oncol. 2022. PMID: 33751805 Free PMC article.
One is that lncRNA-ZXF1 functions as a molecular sponge of miR-378a-3p to regulate PCDHA3 expression and then modulate the expression of P21. The other is that lncRNA-ZXF1 inhibits CDC20-mediated degradation of ubiquitination by directly binding to P21. ...
One is that lncRNA-ZXF1 functions as a molecular sponge of miR-378a-3p to regulate PCDHA3 expression and then modulate the expression …
Exome sequencing in a family with restless legs syndrome.
Weissbach A, Siegesmund K, Brüggemann N, Schmidt A, Kasten M, Pichler I, Muhle H, Lohmann E, Lohnau T, Schwinger E, Hagenah J, Stephani U, Pramstaller PP, Klein C, Lohmann K. Weissbach A, et al. Mov Disord. 2012 Nov;27(13):1686-9. doi: 10.1002/mds.25191. Mov Disord. 2012. PMID: 23192925
RESULTS: We identified three novel missense and one splice site variant in the PCDHA3, WWC2, ATRN, and FAT2 genes that segregated with RLS in the family. All four exons of the PCDHA3 gene, the most plausible candidate, were sequenced in 64 unrelated RLS cases and 25 …
RESULTS: We identified three novel missense and one splice site variant in the PCDHA3, WWC2, ATRN, and FAT2 genes that segregated wit …
Novel ultra-rare exonic variants identified in a founder population implicate cadherins in schizophrenia.
Lencz T, Yu J, Khan RR, Flaherty E, Carmi S, Lam M, Ben-Avraham D, Barzilai N, Bressman S, Darvasi A, Cho JH, Clark LN, Gümüş ZH, Vijai J, Klein RJ, Lipkin S, Offit K, Ostrer H, Ozelius LJ, Peter I, Malhotra AK, Maniatis T, Atzmon G, Pe'er I. Lencz T, et al. Neuron. 2021 May 5;109(9):1465-1478.e4. doi: 10.1016/j.neuron.2021.03.004. Epub 2021 Mar 22. Neuron. 2021. PMID: 33756103 Free PMC article.
We report a recurrent case mutation in PCDHA3 that results in the formation of cytoplasmic aggregates and failure to engage in homophilic interactions on the plasma membrane in cultured cells. ...
We report a recurrent case mutation in PCDHA3 that results in the formation of cytoplasmic aggregates and failure to engage in homoph …
Maternal immune activation downregulates schizophrenia genes in the foetal mouse brain.
Handunnetthi L, Saatci D, Hamley JC, Knight JC. Handunnetthi L, et al. Brain Commun. 2021 Nov 15;3(4):fcab275. doi: 10.1093/braincomms/fcab275. eCollection 2021. Brain Commun. 2021. PMID: 34859219 Free PMC article.
Subsequently, we used gene expression information from herpes simplex virus 1 infection of neuronal precursor cells as orthogonal evidence to support our findings and to demonstrate that schizophrenia-associated cell adhesion genes, PCDHA2, PCDHA3 and PCDHA5, were downregu …
Subsequently, we used gene expression information from herpes simplex virus 1 infection of neuronal precursor cells as orthogonal evidence t …
miR-218-5p and miR-320a-5p as Biomarkers for Brain Disorders: Focus on the Major Depressive Disorder and Parkinson's Disease.
Wan Z, Rasheed M, Li Y, Li Q, Wang P, Li J, Chen Z, Du J, Deng Y. Wan Z, et al. Mol Neurobiol. 2023 Oct;60(10):5642-5654. doi: 10.1007/s12035-023-03391-y. Epub 2023 Jun 17. Mol Neurobiol. 2023. PMID: 37329382
Additional analysis revealed PIK3R1, ATRX, BM1, PCDHA10, XRCC5, PPP1CB, MLLT3, CBL, PCDHA4, PLCG1, YWHAZ, CDH2, AGO3, PCDHA3, and PCDHA11 as hub-genes in PPI network. In summary, our findings show that miR-218-5p and miR-320-5p can be utilized as future biomarkers for depr …
Additional analysis revealed PIK3R1, ATRX, BM1, PCDHA10, XRCC5, PPP1CB, MLLT3, CBL, PCDHA4, PLCG1, YWHAZ, CDH2, AGO3, PCDHA3, and PCD …
Protocadherin alpha gene cluster variants are potentially associated with short root anomaly in Japanese.
Ikeda-Sagawa Y, Ogawa T, Sudo T, Nagata Y, Tanaka T, Moriyama K. Ikeda-Sagawa Y, et al. Eur J Orthod. 2025 Sep 17;47(5):cjaf065. doi: 10.1093/ejo/cjaf065. Eur J Orthod. 2025. PMID: 40988636
We identified four missense variants in five cases within the protocadherin alpha (PCDHA) gene cluster, associated with calcium-dependent cell adhesion. The variants were as follows: PCDHA3 (c.79G>C, p.Gly27Arg), PCDHA6 (c.2279C>T, p.Ser760Phe), PCDHA9 (c.1490G>A, …
We identified four missense variants in five cases within the protocadherin alpha (PCDHA) gene cluster, associated with calcium-dependent ce …