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Year Number of Results
1981 1
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1993 8
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1995 7
1996 4
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1999 7
2000 5
2001 5
2002 3
2003 5
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2006 10
2007 12
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2009 9
2010 19
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892 results

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Page 1
A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARalpha and PCK1.
Gallage S, Ali A, Barragan Avila JE, Seymen N, Ramadori P, Joerke V, Zizmare L, Aicher D, Gopalsamy IK, Fong W, Kosla J, Focaccia E, Li X, Yousuf S, Sijmonsma T, Rahbari M, Kommoss KS, Billeter A, Prokosch S, Rothermel U, Mueller F, Hetzer J, Heide D, Schinkel B, Machauer T, Pichler B, Malek NP, Longerich T, Roth S, Rose AJ, Schwenck J, Trautwein C, Karimi MM, Heikenwalder M. Gallage S, et al. Cell Metab. 2024 Jun 4;36(6):1371-1393.e7. doi: 10.1016/j.cmet.2024.04.015. Epub 2024 May 7. Cell Metab. 2024. PMID: 38718791 Free article.
Combined proteome, transcriptome, and metabolome analyses identified that peroxisome-proliferator-activated receptor alpha (PPARalpha) and glucocorticoid-signaling-induced PCK1 act co-operatively as hepatic executors of the fasting response. In line with this, PPARalpha ta …
Combined proteome, transcriptome, and metabolome analyses identified that peroxisome-proliferator-activated receptor alpha (PPARalpha) and g …
Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K/AKT/PDGF axis activation in male mice.
Ye Q, Liu Y, Zhang G, Deng H, Wang X, Tuo L, Chen C, Pan X, Wu K, Fan J, Pan Q, Wang K, Huang A, Tang N. Ye Q, et al. Nat Commun. 2023 Mar 14;14(1):1402. doi: 10.1038/s41467-023-37142-3. Nat Commun. 2023. PMID: 36918564 Free PMC article.
We demonstrated that phosphoenolpyruvate carboxykinase 1 (PCK1) plays a central role in MAFLD progression. Male mice with liver Pck1 deficiency fed a normal diet displayed hepatic lipid disorder and liver injury, whereas fibrosis and inflammation were aggravated in …
We demonstrated that phosphoenolpyruvate carboxykinase 1 (PCK1) plays a central role in MAFLD progression. Male mice with liver Pc …
The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis.
Xu D, Wang Z, Xia Y, Shao F, Xia W, Wei Y, Li X, Qian X, Lee JH, Du L, Zheng Y, Lv G, Leu JS, Wang H, Xing D, Liang T, Hung MC, Lu Z. Xu D, et al. Nature. 2020 Apr;580(7804):530-535. doi: 10.1038/s41586-020-2183-2. Epub 2020 Apr 8. Nature. 2020. PMID: 32322062
Here we show that activated AKT in human hepatocellular carcinoma (HCC) cells phosphorylates cytosolic phosphoenolpyruvate carboxykinase 1 (PCK1), the rate-limiting enzyme in gluconeogenesis, at Ser90. Phosphorylated PCK1 translocates to the endoplasmic reticulum, w …
Here we show that activated AKT in human hepatocellular carcinoma (HCC) cells phosphorylates cytosolic phosphoenolpyruvate carboxykinase 1 ( …
PCK1 Protects against Mitoribosomal Defects in Diabetic Nephropathy in Mouse Models.
Hasegawa K, Sakamaki Y, Tamaki M, Wakino S. Hasegawa K, et al. J Am Soc Nephrol. 2023 Aug 1;34(8):1343-1365. doi: 10.1681/ASN.0000000000000156. Epub 2023 May 18. J Am Soc Nephrol. 2023. PMID: 37199399 Free PMC article.
We describe the novel role of PEPCK1 as a mitoribosomal protector using Pck1 transgenic (TG) mice and knockout mice. Pck1 blocks excessive glycolysis by suppressing the upregulation of excess HK2 (the rate-limiting enzyme of glycolysis). Notably, Pck1 overexp …
We describe the novel role of PEPCK1 as a mitoribosomal protector using Pck1 transgenic (TG) mice and knockout mice. Pck1 bloc …
Gluconeogenic enzyme PCK1 deficiency promotes CHK2 O-GlcNAcylation and hepatocellular carcinoma growth upon glucose deprivation.
Xiang J, Chen C, Liu R, Gou D, Chang L, Deng H, Gao Q, Zhang W, Tuo L, Pan X, Liang L, Xia J, Huang L, Yao K, Wang B, Hu Z, Huang A, Wang K, Tang N. Xiang J, et al. J Clin Invest. 2021 Apr 15;131(8):e144703. doi: 10.1172/JCI144703. J Clin Invest. 2021. PMID: 33690219 Free PMC article.
The gluconeogenic enzyme phosphoenolpyruvate carboxykinase 1 (PCK1) is downregulated in hepatocellular carcinoma (HCC). However, little is known about the potential role of PCK1 in enhanced HBP activity and HCC carcinogenesis under glucose-limited conditions. In thi …
The gluconeogenic enzyme phosphoenolpyruvate carboxykinase 1 (PCK1) is downregulated in hepatocellular carcinoma (HCC). However, litt …
PCK1 dysregulation in cancer: Metabolic reprogramming, oncogenic activation, and therapeutic opportunities.
Xiang J, Wang K, Tang N. Xiang J, et al. Genes Dis. 2022 Mar 22;10(1):101-112. doi: 10.1016/j.gendis.2022.02.010. eCollection 2023 Jan. Genes Dis. 2022. PMID: 37013052 Free PMC article. Review.
PCK1 expression in gluconeogenic tissues is tightly regulated during fasting. In tumor cells, PCK1 is regulated in a cell-autonomous manner rather than by hormones or nutrients in the extracellular environment. ...In this review, we summarize the mechanisms underlyi …
PCK1 expression in gluconeogenic tissues is tightly regulated during fasting. In tumor cells, PCK1 is regulated in a cell-auto …
Gluconeogenic enzyme PCK1 supports S-adenosylmethionine biosynthesis and promotes H3K9me3 modification to suppress hepatocellular carcinoma progression.
Gou D, Liu R, Shan X, Deng H, Chen C, Xiang J, Liu Y, Gao Q, Li Z, Huang A, Wang K, Tang N. Gou D, et al. J Clin Invest. 2023 Jul 3;133(13):e161713. doi: 10.1172/JCI161713. J Clin Invest. 2023. PMID: 37166978 Free PMC article.
In this study, we discovered that the gluconeogenic enzyme PCK1 fueled the generation of S-adenosylmethionine (SAM) through the serine synthesis pathway. ...Intriguingly, the progression of hepatocellular carcinoma (HCC) driven by PCK1 deficiency was suppressed by S …
In this study, we discovered that the gluconeogenic enzyme PCK1 fueled the generation of S-adenosylmethionine (SAM) through the serin …
PCK1 inhibits cGAS-STING activation by consumption of GTP to promote tumor immune evasion.
Qin W, Duan Y, Hu Z, Hou Y, Wen T, Ouyang Y, Wang Z, Sun X, Chen X, Wang KL, Luo S, Ji G, Shen Y, Dong B, Lin Y, Tian Q, Guo Z, Wu S, Xiao L, Li M, Xiao L, Wu Q, Meng Y, Liu G, Zhang W, Duan S, Bai X, Liu T, He J, Lu Z, Xu D. Qin W, et al. J Exp Med. 2025 May 5;222(5):e20240902. doi: 10.1084/jem.20240902. Epub 2025 Mar 6. J Exp Med. 2025. PMID: 40048154
Here, we demonstrate that hypoxic stimulation induces JNK1/2-mediated S151 phosphorylation of phosphoenolpyruvate carboxykinase 1 (PCK1), a rate-limiting enzyme in gluconeogenesis. This phosphorylation triggers the interaction between PCK1 and cGAS. The PCK1 …
Here, we demonstrate that hypoxic stimulation induces JNK1/2-mediated S151 phosphorylation of phosphoenolpyruvate carboxykinase 1 (PCK1 …
m 6 A-mediated gluconeogenic enzyme PCK1 upregulation protects against hepatic ischemia-reperfusion injury.
Yu S, Liu X, Xu Y, Pan L, Zhang Y, Li Y, Dong S, Tu D, Sun Y, Zhang Y, Zhou Z, Liang X, Huang Y, Chu J, Tu S, Liu C, Chen H, Chen W, Ge M, Zhang Q. Yu S, et al. Hepatology. 2025 Jan 1;81(1):94-110. doi: 10.1097/HEP.0000000000000716. Epub 2023 Dec 12. Hepatology. 2025. PMID: 38085830
However, blocking gluconeogenesis with PCK1 inhibitor aggravated hepatic I/R injury by decreasing glucose level and deepening lactate accumulation, while overexpressing PCK1 did the opposite. Further mechanistic study showed that methyltransferase 3-mediated RNA N6- …
However, blocking gluconeogenesis with PCK1 inhibitor aggravated hepatic I/R injury by decreasing glucose level and deepening lactate …
PCK1 as a target for cancer therapy: from metabolic reprogramming to immune microenvironment remodeling.
Liu N, Zhu XR, Wu CY, Liu YY, Chen MB, Gu JH. Liu N, et al. Cell Death Discov. 2024 Nov 22;10(1):478. doi: 10.1038/s41420-024-02240-8. Cell Death Discov. 2024. PMID: 39578429 Free PMC article. Review.
Herein, we provide a comprehensive overview of the functions of PCK1 under physiological and pathological conditions and suggest that PCK1 is a potential target for cancer therapy. We also propose a future exploration direction for targeting PCK1 for cancer t …
Herein, we provide a comprehensive overview of the functions of PCK1 under physiological and pathological conditions and suggest that …
892 results