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Page 1
PDCD11 Stabilizes C-MYC Oncoprotein by Hindering C-MYC-SKP2 Negative Feedback Loop to Facilitate Progression of p53-Mutant Breast and Colon Malignancies.
Ding L, Ni W, Ma Y, Xu L, Zhang Z, Liao K, Li J, Mei X, Wang Z, Ge H, Li J, Tang D, Zhang X. Ding L, et al. Adv Sci (Weinh). 2025 May;12(17):e2502416. doi: 10.1002/advs.202502416. Epub 2025 Mar 7. Adv Sci (Weinh). 2025. PMID: 40051297 Free PMC article.
In the nucleoplasm, PDCD11 binds to the TAD of C-MYC to prevent SKP2, a transcriptional target of C-MYC as well as one of the major E3 ligase components targeting C-MYC, from interacting with and ubiquitinating C-MYC in feedback. ...These findings highlight PDCD11 a …
In the nucleoplasm, PDCD11 binds to the TAD of C-MYC to prevent SKP2, a transcriptional target of C-MYC as well as one of the major E …
Yolk sac-derived Pdcd11-positive cells modulate zebrafish microglia differentiation through the NF-kappaB-Tgfbeta1 pathway.
Yang R, Zhan M, Guo M, Yuan H, Wang Y, Zhang Y, Zhang W, Chen S, de The H, Chen Z, Zhou J, Zhu J. Yang R, et al. Cell Death Differ. 2021 Jan;28(1):170-183. doi: 10.1038/s41418-020-0591-3. Epub 2020 Jul 24. Cell Death Differ. 2021. PMID: 32709934 Free PMC article.
In this study, we identified the cerebral white matter hyperintensities susceptibility gene, programmed cell death protein 11 (PDCD11), as an essential factor regulating microglia differentiation. In zebrafish, pdcd11 deficiency prevents the differentiation of the p …
In this study, we identified the cerebral white matter hyperintensities susceptibility gene, programmed cell death protein 11 (PDCD11 …
CircRNA circ-PDCD11 is highly expressed in lung large-cell carcinoma and predicts poor survival.
Ma T, Miao H, Xiong Y, Ma Y, Dong Z. Ma T, et al. Immunopharmacol Immunotoxicol. 2023 Feb;45(1):89-93. doi: 10.1080/08923973.2022.2117628. Epub 2022 Sep 28. Immunopharmacol Immunotoxicol. 2023. PMID: 36017647
Paired tumor and nontumor tissue samples were obtained from all patients. Expression of circ-PDCD11 in these samples was determined by RT-qPCR. The role of plasma circ-PDCD11 in the diagnosis of LLCC was analyzed with ROC curve. ...High plasma circ-PDCD11 lev …
Paired tumor and nontumor tissue samples were obtained from all patients. Expression of circ-PDCD11 in these samples was determined b …
Rare PDCD11 variations are not associated with risk of schizophrenia in Japan.
Hoya S, Watanabe Y, Hishimoto A, Nunokawa A, Kaneko N, Muratake T, Shinmyo N, Otsuka I, Okuda S, Inoue E, Igeta H, Shibuya M, Egawa J, Orime N, Sora I, Someya T. Hoya S, et al. Psychiatry Clin Neurosci. 2017 Nov;71(11):780-788. doi: 10.1111/pcn.12549. Epub 2017 Jul 31. Psychiatry Clin Neurosci. 2017. PMID: 28657695 Free article.
In the second stage, we performed targeted resequencing of the PDCD11 coding region in 96 patients. In the third stage, we conducted an association study of rare PDCD11 variations with schizophrenia in a total of 1357 patients and 1394 controls. ...Targeted resequen …
In the second stage, we performed targeted resequencing of the PDCD11 coding region in 96 patients. In the third stage, we conducted …
High expression of PDCD11 in colorectal cancer and its correlation with the prognosis and immune cell infiltration.
Li X, Sharen G, Zhang M, Zhang L, Liu K, Wang Y, Cheng H, Hou M. Li X, et al. Heliyon. 2024 Jul 23;10(15):e35002. doi: 10.1016/j.heliyon.2024.e35002. eCollection 2024 Aug 15. Heliyon. 2024. PMID: 39170455 Free PMC article.
Moreover, mRNA and protein expression data of PDCD11 were attained from the HPA database. It was attempted to establish protein-protein interaction networks of PDCD11 via the STRING and GeneMANIA databases. ...Furthermore, the relationship of PDCD11 expressio …
Moreover, mRNA and protein expression data of PDCD11 were attained from the HPA database. It was attempted to establish protein-prote …
Elevation of autoantibody level against PDCD11 in patients with transient ischemic attack.
Yoshida Y, Wang H, Hiwasa T, Machida T, Kobayashi E, Mine S, Tomiyoshi G, Nakamura R, Shinmen N, Kuroda H, Takizawa H, Kashiwado K, Kamitsukasa I, Shin H, Wada T, Aotsuka A, Nishi E, Ohno M, Takemoto M, Yokote K, Takahashi S, Matsushima J, Zhang XM, Takiguchi M, Iwadate Y. Yoshida Y, et al. Oncotarget. 2017 Dec 24;9(10):8836-8848. doi: 10.18632/oncotarget.23653. eCollection 2018 Feb 6. Oncotarget. 2017. PMID: 29507658 Free PMC article.
The validation cohort revealed significantly higher antibody levels against PDCD11 (PDCD11-Ab levels) in patients with TIA than in HDs. Multivariate logistic regression analysis indicated that the predictive value of PDCD11-Ab levels for TIA [Odds ratio (OR): …
The validation cohort revealed significantly higher antibody levels against PDCD11 (PDCD11-Ab levels) in patients with TIA tha …
Programmed cell death 11 modulates but not entirely relies on p53-HDM2 loop to facilitate G2/M transition in colorectal cancer cells.
Ding L, Xu Y, Xu L, Zhao C, Zhang Z, Zhang J, Liao K, Chen Y, Li J, Mei X, Zhang X. Ding L, et al. Oncogenesis. 2023 Dec 7;12(1):57. doi: 10.1038/s41389-023-00501-2. Oncogenesis. 2023. PMID: 38062028 Free PMC article.
The ensuing downregulation of p53 increases the CDK1 level to help the cells pass G2/M checkpoint. Upon DNA damage stress, PDCD11 gains the power to upregulate CDK1 independently of p53. Beyond these, PDCD11 also upregulates CDC25C in a p53-independent manner to dep …
The ensuing downregulation of p53 increases the CDK1 level to help the cells pass G2/M checkpoint. Upon DNA damage stress, PDCD11 gai …
miR-136: A biomarker in the inflammation-cancer transformation of gastric cancer.
Lyu H, Chen JS, Tang JF, Zhou CF. Lyu H, et al. World J Gastrointest Oncol. 2025 Dec 15;17(12):114173. doi: 10.4251/wjgo.v17.i12.114173. World J Gastrointest Oncol. 2025. PMID: 41480196 Free PMC article.
Their key findings indicate that Helicobacter pylori (H. pylori) activated NF-kappaB/miR-136/PDCD11 axis to induce the growth of H. pylori-positive GC tumors. And miR-136 is markedly associated with characteristics related to the gastric mucosal histopathological, supporti …
Their key findings indicate that Helicobacter pylori (H. pylori) activated NF-kappaB/miR-136/PDCD11 axis to induce the growth of H. p …
Helicobacter pylori-induced miR-136 is a potential predictor of early-stage gastric cancer.
Chen T, Feng AQ, Shen XR, Dang NY, Ye F, Zhang GX. Chen T, et al. World J Gastrointest Oncol. 2025 Oct 15;17(10):109744. doi: 10.4251/wjgo.v17.i10.109744. World J Gastrointest Oncol. 2025. PMID: 41114105 Free PMC article.
Nuclear factor kappa-B (NF-kappaB)/miR-136/PDCD11 interactions were confirmed by luciferase and inhibition assays. For in vivo studies H. pylori-infected BGC-823 cells were injected into nude mice. ...Mechanistically, upregulation of miR-136 suppressed PDCD11 throug …
Nuclear factor kappa-B (NF-kappaB)/miR-136/PDCD11 interactions were confirmed by luciferase and inhibition assays. For in vivo studie …
31 results