Search Page

1

Cite

Share

Role of hepatic efflux transporters in regulating systemic and hepatocyte exposure to xenobiotics.

Pfeifer ND, Hardwick RN, Brouwer KL. Pfeifer ND, et al. Annu Rev Pharmacol Toxicol. 2014;54:509-35. doi: 10.1146/annurev-pharmtox-011613-140021. Epub 2013 Oct 23. Annu Rev Pharmacol Toxicol. 2014. PMID: 24160696 Review.

Cite

Share

2

Cite

Share

Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity.

Swift B, Pfeifer ND, Brouwer KL. Swift B, et al. Among authors: pfeifer nd. Drug Metab Rev. 2010 Aug;42(3):446-71. doi: 10.3109/03602530903491881. Drug Metab Rev. 2010. PMID: 20109035 Free PMC article. Review.

Cite

Share

3

Cite

Share

A phase 2 multiple ascending dose study of the inhaled pan-JAK inhibitor nezulcitinib (TD-0903) in severe COVID-19.

Singh D, Bogus M, Moskalenko V, Lord R, Moran EJ, Crater GD, Bourdet DL, Pfeifer ND, Woo J, Kaufman E, Lombardi DA, Weng EY, Nguyen T, Woodcock A, Haumann B, Saggar R. Singh D, et al. Among authors: pfeifer nd. Eur Respir J. 2021 Oct 14;58(4):2100673. doi: 10.1183/13993003.00673-2021. Print 2021 Oct. Eur Respir J. 2021. PMID: 34210790 Free article. Clinical Trial. No abstract available.

Cite

Share

4

Cite

Share

Phase I study in healthy participants to evaluate safety, tolerability, and pharmacokinetics of inhaled nezulcitinib, a potential treatment for COVID-19.

Pfeifer ND, Lo A, Bourdet DL, Colley K, Singh D. Pfeifer ND, et al. Clin Transl Sci. 2021 Nov;14(6):2556-2565. doi: 10.1111/cts.13123. Epub 2021 Aug 31. Clin Transl Sci. 2021. PMID: 34318597 Free PMC article. Clinical Trial.

Cite

Share

5

Cite

Share

Adalimumab long-term safety: infections, vaccination response and pregnancy outcomes in patients with rheumatoid arthritis.

Burmester GR, Landewé R, Genovese MC, Friedman AW, Pfeifer ND, Varothai NA, Lacerda AP. Burmester GR, et al. Among authors: pfeifer nd. Ann Rheum Dis. 2017 Feb;76(2):414-417. doi: 10.1136/annrheumdis-2016-209322. Epub 2016 Jun 23. Ann Rheum Dis. 2017. PMID: 27338778 Free PMC article.

Cite

Share

6

Cite

Share

Species differences in hepatobiliary disposition of taurocholic acid in human and rat sandwich-cultured hepatocytes: implications for drug-induced liver injury.

Yang K, Pfeifer ND, Köck K, Brouwer KL. Yang K, et al. Among authors: pfeifer nd. J Pharmacol Exp Ther. 2015 May;353(2):415-23. doi: 10.1124/jpet.114.221564. Epub 2015 Feb 23. J Pharmacol Exp Ther. 2015. PMID: 25711339 Free PMC article.

Cite

Share

7

Cite

Share

Expression, purification and characterization of the human membrane transporter protein OATP2B1 from Sf9 insect cells.

Tschantz WR, Pfeifer ND, Meade CL, Wang L, Lanzetti A, Kamath AV, Berlioz-Seux F, Hashim MF. Tschantz WR, et al. Among authors: pfeifer nd. Protein Expr Purif. 2008 Feb;57(2):163-71. doi: 10.1016/j.pep.2007.10.007. Epub 2007 Oct 17. Protein Expr Purif. 2008. PMID: 18024077

Cite

Share

8

Cite

Share

Determination of intracellular unbound concentrations and subcellular localization of drugs in rat sandwich-cultured hepatocytes compared with liver tissue.

Pfeifer ND, Harris KB, Yan GZ, Brouwer KL. Pfeifer ND, et al. Drug Metab Dispos. 2013 Nov;41(11):1949-56. doi: 10.1124/dmd.113.052134. Epub 2013 Aug 29. Drug Metab Dispos. 2013. PMID: 23990525 Free PMC article.

Cite

Share

9

Cite

Share

Effect of Ritonavir on (99m)Technetium-Mebrofenin Disposition in Humans: A Semi-PBPK Modeling and In Vitro Approach to Predict Transporter-Mediated DDIs.

Pfeifer ND, Goss SL, Swift B, Ghibellini G, Ivanovic M, Heizer WD, Gangarosa LM, Brouwer KL. Pfeifer ND, et al. CPT Pharmacometrics Syst Pharmacol. 2013 Jan 2;2(1):e20. doi: 10.1038/psp.2012.21. CPT Pharmacometrics Syst Pharmacol. 2013. PMID: 23887590 Free PMC article.

Cite

Share

10

Cite

Share

An experimental approach to evaluate the impact of impaired transport function on hepatobiliary drug disposition using Mrp2-deficient TR- rat sandwich-cultured hepatocytes in combination with Bcrp knockdown.

Yang K, Pfeifer ND, Hardwick RN, Yue W, Stewart PW, Brouwer KL. Yang K, et al. Among authors: pfeifer nd. Mol Pharm. 2014 Mar 3;11(3):766-75. doi: 10.1021/mp400471e. Epub 2014 Jan 30. Mol Pharm. 2014. PMID: 24410402 Free PMC article.

Cite

Share