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528 results

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Page 1
PHF1 compartmentalizes PRC2 via phase separation.
Lu G, Li P. Lu G, et al. Biochem J. 2023 Nov 29;480(22):1833-1844. doi: 10.1042/BCJ20230040. Biochem J. 2023. PMID: 37888776
In this report, we demonstrate that a PCL protein named PHF1 forms phase-separated condensates at H3K27me3 loci that recruit PRC2. Combining cellular observation and biochemical reconstitution, we show that the N-terminal domains of PHF1 cooperatively mediate target …
In this report, we demonstrate that a PCL protein named PHF1 forms phase-separated condensates at H3K27me3 loci that recruit PRC2. Co …
A novel MBTD1-PHF1 gene fusion in endometrial stromal sarcoma: A case report and literature review.
Han L, Liu YJ, Ricciotti RW, Mantilla JG. Han L, et al. Genes Chromosomes Cancer. 2020 Jul;59(7):428-432. doi: 10.1002/gcc.22845. Epub 2020 Apr 15. Genes Chromosomes Cancer. 2020. PMID: 32237188 Review.
Low-grade ESS (LG-ESS) is most commonly characterized by JAZF1-SUZ12 fusions followed by rearrangements involving PHD finger protein-1 (PHF1) and multiple fusion partners, including JAZF1, EPC1, EPC2, and MEAF6. In the present study, integrating anchored polymerase chain r …
Low-grade ESS (LG-ESS) is most commonly characterized by JAZF1-SUZ12 fusions followed by rearrangements involving PHD finger protein-1 (P …
Novel recurrent PHF1-TFE3 fusions in ossifying fibromyxoid tumors.
Suurmeijer AJH, Song W, Sung YS, Zhang L, Swanson D, Fletcher CDM, Dickson BC, Antonescu CR. Suurmeijer AJH, et al. Genes Chromosomes Cancer. 2019 Sep;58(9):643-649. doi: 10.1002/gcc.22755. Epub 2019 Apr 17. Genes Chromosomes Cancer. 2019. PMID: 30920708 Free PMC article.
Ossifying fibromyxoid tumor (OFMT) is an uncommon mesenchymal neoplasm of uncertain differentiation and intermediate malignant potential. Recurrent PHF1 gene rearrangements are detected in up to 80% of OFMTs. We describe the clinicopathologic features of five OFMTs harbori …
Ossifying fibromyxoid tumor (OFMT) is an uncommon mesenchymal neoplasm of uncertain differentiation and intermediate malignant potential. Re …
PHF1::TFE3-positive fibromyxoid sarcoma? Report of 2 cases and review of 13 cases of PHF1::TFE3-positive ossifying fibromyxoid tumor in the literature.
Wei S, Patchefsky AS, Pei J, Brown SA, Basu Mallick A, Wang Z, Jiang W. Wei S, et al. Am J Clin Pathol. 2025 Feb 12;163(2):224-230. doi: 10.1093/ajcp/aqae114. Am J Clin Pathol. 2025. PMID: 39250713 Review.
Most OFMTs have benign behavior, and many harbor gene fusions involving the PHD finger protein 1 (PHF1), such as EP400::PHF1, MEAF6::PHF1, EPC1::PHF1, and PHF1::TFE3. The PHF1::TFE3 fusion is unique because PHF1 is at 5' instead of …
Most OFMTs have benign behavior, and many harbor gene fusions involving the PHD finger protein 1 (PHF1), such as EP400::PHF1, …
PHF1 fusions cause distinct gene expression and chromatin accessibility profiles in ossifying fibromyxoid tumors and mesenchymal cells.
Hofvander J, Jo VY, Fletcher CDM, Puls F, Flucke U, Nilsson J, Magnusson L, Mertens F. Hofvander J, et al. Mod Pathol. 2020 Jul;33(7):1331-1340. doi: 10.1038/s41379-020-0457-8. Epub 2020 Jan 13. Mod Pathol. 2020. PMID: 31932680 Free article.
Ossifying fibromyxoid tumor (OFMT) is a soft tissue tumor frequently displaying gene fusions, most of which affect the PHF1 gene. PHF1 encodes plant homeodomain finger protein 1, which is involved in various processes regulating gene transcription, including those o …
Ossifying fibromyxoid tumor (OFMT) is a soft tissue tumor frequently displaying gene fusions, most of which affect the PHF1 gene. …
PHF1 Tudor and N-terminal domains synergistically target partially unwrapped nucleosomes to increase DNA accessibility.
Gibson MD, Gatchalian J, Slater A, Kutateladze TG, Poirier MG. Gibson MD, et al. Nucleic Acids Res. 2017 Apr 20;45(7):3767-3776. doi: 10.1093/nar/gkw1320. Nucleic Acids Res. 2017. PMID: 28082396 Free PMC article.
The Tudor domain of human PHF1 recognizes trimethylated lysine 36 on histone H3 (H3K36me3). PHF1 relies on this interaction to regulate PRC2 methyltransferase activity, localize to DNA double strand breaks and mediate nucleosome accessibility. ...We demonstrate that …
The Tudor domain of human PHF1 recognizes trimethylated lysine 36 on histone H3 (H3K36me3). PHF1 relies on this interaction to …
Down-regulated m6A reader FTO destabilizes PHF1 that triggers enhanced stemness capacity and tumor progression in lung adenocarcinoma.
Ning J, Wang F, Bu J, Zhu K, Liu W. Ning J, et al. Cell Death Discov. 2022 Aug 9;8(1):354. doi: 10.1038/s41420-022-01125-y. Cell Death Discov. 2022. PMID: 35945194 Free PMC article.
Patients with low PHF1 had poorer survival outcomes relative to those with high PHF1. Targeting PHF1 potentiated cell growth, migration and in vivo proliferation. Mechanistically, FTO mediated the stabilization of PHF1 mRNA by demethylating m6A, which …
Patients with low PHF1 had poorer survival outcomes relative to those with high PHF1. Targeting PHF1 potentiated cell g …
Detection of MEAF6-PHF1 translocation in an endometrial stromal nodule.
Nomura Y, Tamura D, Horie M, Sato M, Sasaki S, Yamamoto Y, Kudo-Asabe Y, Umakoshi M, Koyama K, Makino K, Takashima S, Imai K, Minamiya Y, Munakata S, Yachida S, Terada Y, Goto A, Maeda D. Nomura Y, et al. Genes Chromosomes Cancer. 2020 Aug 20. doi: 10.1002/gcc.22892. Online ahead of print. Genes Chromosomes Cancer. 2020. PMID: 32820570
The finding that MEAF6-PHF1 fusion is a background genetic abnormality detected both in ESN and LG-ESS, along with JAZF1-SUZ12, provides further support for the similarity and continuum between these two types of ESTs. Furthermore, the association between metaplastic bone …
The finding that MEAF6-PHF1 fusion is a background genetic abnormality detected both in ESN and LG-ESS, along with JAZF1-SUZ12, provi …
PHF1 is required for chromosome alignment and asymmetric division during mouse meiotic oocyte maturation.
Qu Y, Wang Y, Qiao J. Qu Y, et al. Cell Cycle. 2018;17(21-22):2447-2459. doi: 10.1080/15384101.2018.1542896. Epub 2018 Nov 11. Cell Cycle. 2018. PMID: 30382790 Free PMC article.
A previous study by our group using single cell transcriptome analysis and high-throughput technology revealed that PHF1 mRNA was elevated in the human oocyte and the early preimplantation embryo. This suggests that PHF1 may play an important role in oocyte maturati …
A previous study by our group using single cell transcriptome analysis and high-throughput technology revealed that PHF1 mRNA was ele …
528 results