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Improving the selectivity of 3-amidinophenylalanine-derived matriptase inhibitors.
Pilgram O, Keils A, Benary GE, Müller J, Merkl S, Ngaha S, Huber S, Chevillard F, Harbig A, Magdolen V, Heine A, Böttcher-Friebertshäuser E, Steinmetzer T. Pilgram O, et al. Eur J Med Chem. 2022 Aug 5;238:114437. doi: 10.1016/j.ejmech.2022.114437. Epub 2022 May 12. Eur J Med Chem. 2022. PMID: 35635944
TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells.
Bestle D, Heindl MR, Limburg H, Van Lam van T, Pilgram O, Moulton H, Stein DA, Hardes K, Eickmann M, Dolnik O, Rohde C, Klenk HD, Garten W, Steinmetzer T, Böttcher-Friebertshäuser E. Bestle D, et al. Among authors: pilgram o. Life Sci Alliance. 2020 Jul 23;3(9):e202000786. doi: 10.26508/lsa.202000786. Print 2020 Sep. Life Sci Alliance. 2020. PMID: 32703818 Free PMC article.
In vitro interaction of potential antiviral TMPRSS2 inhibitors with human serum albumin and cytochrome P 450 isoenzymes.
Pászti-Gere E, Szentkirályi A, Fedor Z, Nagy G, Szimrók Z, Pászti Z, Pászti A, Pilgram O, Steinmetzer T, Bodnárová S, Fliszár-Nyúl E, Poór M. Pászti-Gere E, et al. Among authors: pilgram o. Biomed Pharmacother. 2022 Feb;146:112513. doi: 10.1016/j.biopha.2021.112513. Epub 2021 Dec 13. Biomed Pharmacother. 2022. PMID: 34915414 Free PMC article.