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The mismatch repair endonuclease MutLα tethers duplex regions of DNA together and relieves DNA torsional tension.
Nucleic Acids Res. 2023 Apr 11;51(6):2725-2739. doi: 10.1093/nar/gkad096.
Nucleic Acids Res. 2023.
PMID: 36840719
Free PMC article.
The Mlh1-Pms1 endonuclease uses ATP to preserve DNA discontinuities as strand discrimination signals to facilitate mismatch repair.
Piscitelli JM, Witte SJ, Sakinejad YS, Manhart CM.
Piscitelli JM, et al.
bioRxiv [Preprint]. 2024 Jun 13:2024.06.13.598860. doi: 10.1101/2024.06.13.598860.
bioRxiv. 2024.
PMID: 38915520
Free PMC article.
Preprint.
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