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195 results

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Page 1
Novel PLCZ1 compound heterozygous mutations indicate gene dosage effect involved in total fertilisation failure after ICSI.
Li Q, Guo J, Huang G, Wu N, Chen S, Dai J, Zhang X, Zhang G, Zhi W, Yan J, Zheng R, Yan F, Yan Z, Wu L, Wu S, Ji Z, Zeng J, Lin G, Li B, Xu W. Li Q, et al. Reproduction. 2024 Sep 16;168(4):e230466. doi: 10.1530/REP-23-0466. Print 2024 Oct 1. Reproduction. 2024. PMID: 39042720 Free PMC article.
IN BRIEF: PLCZ1 mutations are related to total fertilisation failure (TFF) after intracytoplasmic sperm injection (ICSI), characterised by abnormal oocyte oscillations. ...Then, the locations of PLCZ1/PLCZ and the transcript and protein levels in the sperm of the pa …
IN BRIEF: PLCZ1 mutations are related to total fertilisation failure (TFF) after intracytoplasmic sperm injection (ICSI), characteris …
Phospholipase C Zeta 1 (PLCZ1): The Function and Potential for Fertility Assessment and In Vitro Embryo Production in Cattle and Horses.
Gonzalez-Castro RA, Carnevale EM. Gonzalez-Castro RA, et al. Vet Sci. 2023 Dec 11;10(12):698. doi: 10.3390/vetsci10120698. Vet Sci. 2023. PMID: 38133249 Free PMC article. Review.
Phospholipase C Zeta 1 (PLCZ1) is considered a major sperm-borne oocyte activation factor. After gamete fusion, PLCZ1 triggers calcium oscillations in the oocyte, resulting in oocyte activation. ...In horses, sperm PLCZ1 varies among stallions, and sperm popu …
Phospholipase C Zeta 1 (PLCZ1) is considered a major sperm-borne oocyte activation factor. After gamete fusion, PLCZ1 triggers …
SPERM FACTORS AND EGG ACTIVATION: The structure and function relationship of sperm PLCZ1.
Thanassoulas A, Swann K, Lai FA, Nomikos M. Thanassoulas A, et al. Reproduction. 2022 May 23;164(1):F1-F8. doi: 10.1530/REP-21-0477. Reproduction. 2022. PMID: 35521907 Review.
The imperative role of PLCZ1 in oocyte activation is revealed by the vast number of human mutations throughout the PLCZ1 gene that have been identified and directly linked with certain forms of male infertility due to oocyte activation deficiency. ...The unravelling …
The imperative role of PLCZ1 in oocyte activation is revealed by the vast number of human mutations throughout the PLCZ1 gene …
SPERM FACTORS AND EGG ACTIVATION: Phospholipase C zeta (PLCZ1) and the clinical diagnosis of oocyte activation deficiency.
Jones C, Meng X, Coward K. Jones C, et al. Reproduction. 2022 May 23;164(1):F53-F66. doi: 10.1530/REP-21-0458. Reproduction. 2022. PMID: 35312629 Free PMC article. Review.
OAD has been linked to numerous PLCZ1 abnormalities in patients experiencing failed in vitro fertilization or intracytoplasmic sperm injection cycles. While significant efforts have enhanced our understanding of the clinical relevance of PLCZ1, and the potential eff …
OAD has been linked to numerous PLCZ1 abnormalities in patients experiencing failed in vitro fertilization or intracytoplasmic sperm …
Plcz1 Deficiency Decreased Fertility in Male Mice Which Is Associated with Sperm Quality Decline and Abnormal Cytoskeleton in Epididymis.
Wang T, Cao B, Cai Y, Chen S, Wang B, Yuan Y, Zhang Q. Wang T, et al. Int J Mol Sci. 2022 Dec 24;24(1):314. doi: 10.3390/ijms24010314. Int J Mol Sci. 2022. PMID: 36613757 Free PMC article.
Plcz1 knockout (Plcz1(-/-)) mouse model (Plcz1(m3) and Plcz1(m5)) was generated by using the CRISPR-Cas9 system. ...In particular, a significant time delay in development and polyspermy was found in eggs fertilized by both Plcz1(m3) and Plcz1 …
Plcz1 knockout (Plcz1(-/-)) mouse model (Plcz1(m3) and Plcz1(m5)) was generated by using the CRISPR-Cas9 system. …
Novel PLCZ1 mutation caused polyspermy during in vitro fertilization.
Tong KY, Liu WW, Sun LW, Liu DY, Xiang YZ, Li C, Chai LW, Chen K, Huang GN, Li JY. Tong KY, et al. Asian J Androl. 2024 Jul 1;26(4):389-395. doi: 10.4103/aja202376. Epub 2024 Mar 5. Asian J Androl. 2024. PMID: 38445955 Free PMC article.
Many studies have shown that phospholipase C zeta 1 ( PLCZ1 ) mutations cause failure of PN formation following intracytoplasmic sperm injection (ICSI); however, whether PLCZ1 mutation is associated with polyspermy during in vitro fertilization (IVF) remains unknown …
Many studies have shown that phospholipase C zeta 1 ( PLCZ1 ) mutations cause failure of PN formation following intracytoplasmic sper …
High rate of detected variants in male PLCZ1 and ACTL7A genes causing failed fertilization after ICSI.
Cardona Barberán A, Reddy Guggilla R, Colenbier C, Van der Velden E, Rybouchkin A, Stoop D, Leybaert L, Coucke P, Symoens S, Boel A, Vanden Meerschaut F, Heindryckx B. Cardona Barberán A, et al. Hum Reprod Open. 2024 Sep 28;2024(4):hoae057. doi: 10.1093/hropen/hoae057. eCollection 2024. Hum Reprod Open. 2024. PMID: 39411542 Free PMC article.
In the first setting, group 1 (N = 28, 2006-2020) underwent only PLCZ1 genetic screening, while group 2 (N = 27, 2020-2023) underwent PLCZ1, ACTL7A, and ACTL9 genetic screening. ...Seven different PLCZ1 variants were identified (p.Ile74Thr, p.Gln94*, p.Arg141 …
In the first setting, group 1 (N = 28, 2006-2020) underwent only PLCZ1 genetic screening, while group 2 (N = 27, 2020-2023) underwent …
Genetic mechanisms of fertilization failure and early embryonic arrest: a comprehensive review.
Wei Y, Wang J, Qu R, Zhang W, Tan Y, Sha Y, Li L, Yin T. Wei Y, et al. Hum Reprod Update. 2024 Jan 3;30(1):48-80. doi: 10.1093/humupd/dmad026. Hum Reprod Update. 2024. PMID: 37758324 Review.
However, in the case of genetic defects such as phospholipase C zeta1 (PLCZ1), actin-like7A (ACTL7A), actin-like 9 (ACTL9), and IQ motif-containing N (IQCN), ICSI may also fail to fertilize. ...
However, in the case of genetic defects such as phospholipase C zeta1 (PLCZ1), actin-like7A (ACTL7A), actin-like 9 (ACTL9), and IQ mo …
SPERM FACTORS AND EGG ACTIVATION: Fertilization failure after human ICSI and the clinical potential of PLCZ1.
Cardona Barberán A, Boel A, Vanden Meerschaut F, Stoop D, Heindryckx B. Cardona Barberán A, et al. Reproduction. 2022 May 23;164(1):F39-F51. doi: 10.1530/REP-21-0387. Reproduction. 2022. PMID: 35038316 Review.
Two decades have passed since the discovery of phospholipase C zeta (PLCZ1) as the sperm oocyte-activating factor. At present, there is a general consensus that PLCZ1 is responsible for triggering the calcium (Ca2+) oscillations necessary to start the oocyte activat …
Two decades have passed since the discovery of phospholipase C zeta (PLCZ1) as the sperm oocyte-activating factor. At present, there …
Novel mutations in PLCZ1 cause male infertility due to fertilization failure or poor fertilization.
Yan Z, Fan Y, Wang F, Yan Z, Li M, Ouyang J, Wu L, Yin M, Zhao J, Kuang Y, Li B, Lyu Q. Yan Z, et al. Hum Reprod. 2020 Feb 29;35(2):472-481. doi: 10.1093/humrep/dez282. Hum Reprod. 2020. PMID: 32048714
LIMITATIONS, REASONS FOR CAUTION: We screened only the whole exons of PLCZ1. Additional possible mutations in the non-coding region of PLCZ1 should be further studied. WIDER IMPLICATIONS OF THE FINDINGS: Our study not only further confirms the important role of P …
LIMITATIONS, REASONS FOR CAUTION: We screened only the whole exons of PLCZ1. Additional possible mutations in the non-coding region o …
195 results