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Year Number of Results
2004 1
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114 results

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Page 1
Glial receptor PLXNB2 regulates schizophrenia-related stress perception via the amygdala.
Xuan FL, Yan L, Li Y, Fan F, Deng H, Gou M, Chithanathan K, Heinla I, Yuan L, Seppa K, Zharkovsky A, Kalda A, Hong LE, Hu GF, Tan Y, Tian L. Xuan FL, et al. Front Immunol. 2022 Oct 17;13:1005067. doi: 10.3389/fimmu.2022.1005067. eCollection 2022. Front Immunol. 2022. PMID: 36325348 Free PMC article.
Blood RNA-seq showed differentially expressed PLXNB2 and its ligands among patient groups and HCs (FDR<0.05~0.01). Amygdaloid size and PLXNB2 level were both negatively correlated with stress perception (p<0.01&0.05, respectively), which fully mediated the …
Blood RNA-seq showed differentially expressed PLXNB2 and its ligands among patient groups and HCs (FDR<0.05~0.01). Amygdaloid size …
In vivo interaction screening reveals liver-derived constraints to metastasis.
Borrelli C, Roberts M, Eletto D, Hussherr MD, Fazilaty H, Valenta T, Lafzi A, Kretz JA, Guido Vinzoni E, Karakatsani A, Adivarahan S, Mannhart A, Kimura S, Meijs A, Baccouche Mhamedi F, Acar IE, Handler K, Ficht X, Platt RJ, Piscuoglio S, Moor AE. Borrelli C, et al. Nature. 2024 Aug;632(8024):411-418. doi: 10.1038/s41586-024-07715-3. Epub 2024 Jul 24. Nature. 2024. PMID: 39048831 Free PMC article.
Barcoded viral tracing of single-cell interactions in central nervous system inflammation.
Clark IC, Gutiérrez-Vázquez C, Wheeler MA, Li Z, Rothhammer V, Linnerbauer M, Sanmarco LM, Guo L, Blain M, Zandee SEJ, Chao CC, Batterman KV, Schwabenland M, Lotfy P, Tejeda-Velarde A, Hewson P, Manganeli Polonio C, Shultis MW, Salem Y, Tjon EC, Fonseca-Castro PH, Borucki DM, Alves de Lima K, Plasencia A, Abate AR, Rosene DL, Hodgetts KJ, Prinz M, Antel JP, Prat A, Quintana FJ. Clark IC, et al. Science. 2021 Apr 23;372(6540):eabf1230. doi: 10.1126/science.abf1230. Science. 2021. PMID: 33888612 Free PMC article.
Osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis.
Liu X, Chai Y, Liu G, Su W, Guo Q, Lv X, Gao P, Yu B, Ferbeyre G, Cao X, Wan M. Liu X, et al. Nat Commun. 2021 Mar 23;12(1):1832. doi: 10.1038/s41467-021-22131-1. Nat Commun. 2021. PMID: 33758201 Free PMC article.
ANG maintains the proliferative activity of endothelial cells through plexin-B2 (PLXNB2)-mediated transcription of ribosomal RNA (rRNA). GC treatment inhibits ANG production by suppressing osteoclast formation in metaphysis, resulting in impaired endothelial cell rRNA tran …
ANG maintains the proliferative activity of endothelial cells through plexin-B2 (PLXNB2)-mediated transcription of ribosomal RNA (rRN …
Mutated axon guidance gene PLXNB2 sustains growth and invasiveness of stem cells isolated from cancers of unknown primary.
Brundu S, Napolitano V, Franzolin G, Lo Cascio E, Mastrantonio R, Sardo G, Cascardi E, Verginelli F, Sarnataro S, Gambardella G, Pisacane A, Arcovito A, Boccaccio C, Comoglio PM, Giraudo E, Tamagnone L. Brundu S, et al. EMBO Mol Med. 2023 Mar 8;15(3):e16104. doi: 10.15252/emmm.202216104. Epub 2023 Feb 1. EMBO Mol Med. 2023. PMID: 36722641 Free PMC article.
In particular, G842C mutation of PlexinB2 (PlxnB2) was predicted to be activating. Indeed, knocking down the mutated, but not the wild-type, PlxnB2 in CUP stem cells resulted in the impairment of self-renewal and proliferation in culture, as well as tumorigenic capa …
In particular, G842C mutation of PlexinB2 (PlxnB2) was predicted to be activating. Indeed, knocking down the mutated, but not the wil …
Biallelic variants in Plexin B2 (PLXNB2) cause amelogenesis imperfecta, hearing loss and intellectual disability.
Smith CEL, Laugel-Haushalter V, Hany U, Best S, Taylor RL, Poulter JA, Wortmann SB, Feichtinger RG, Mayr JA, Al Bahlani S, Nikolopoulos G, Rigby A, Black GC, Watson CM, Mansour S, Inglehearn CF, Mighell AJ, Bloch-Zupan A; UK Inherited Retinal Disease Consortium, Genomics England Research Consortium. Smith CEL, et al. J Med Genet. 2024 Jun 20;61(7):689-698. doi: 10.1136/jmg-2023-109728. J Med Genet. 2024. PMID: 38458752 Free PMC article.
The variants identified include missense, nonsense, splicing changes and a multiexon deletion. Plxnb2 expression was detected in differentiating ameloblasts. CONCLUSION: We identify rare biallelic pathogenic variants in PLXNB2 as a cause of a new autosomal recessive …
The variants identified include missense, nonsense, splicing changes and a multiexon deletion. Plxnb2 expression was detected in diff …
Fibroblasts with high matrix metalloproteinase 2 expression regulate CD8+ T-cell residency and inflammation via CD100 in psoriasis.
Dong C, Lin JM, Lu X, Zhu J, Lin L, Xu J, Du J. Dong C, et al. Br J Dermatol. 2024 Aug 14;191(3):405-418. doi: 10.1093/bjd/ljae205. Br J Dermatol. 2024. PMID: 38752329
These fibroblasts augment psoriasis inflammation through the CD100-PLXNB2 axis by facilitating CD100 shedding on CD8+ T-cell membranes and by upregulating CD103, thereby enhancing CD8+ T-cell residency. ...MMP2 brings about structural alterations in skin tissues and contro …
These fibroblasts augment psoriasis inflammation through the CD100-PLXNB2 axis by facilitating CD100 shedding on CD8+ T-cell membrane …
Expression analysis, clinical significance and potential function of PLXNB2 in acute myeloid leukaemia.
Guo Z, Guo D, Kong D, Bian S, Zhao L, Li Q, Lin L, Hao J, Sun L, Li Y. Guo Z, et al. Mol Biol Rep. 2023 Oct;50(10):8445-8457. doi: 10.1007/s11033-023-08721-w. Epub 2023 Aug 26. Mol Biol Rep. 2023. PMID: 37632633
Differentially expressed genes between the high and low PLXNB2 expression groups were overlapped with PLXNB2-coexpressed genes, and genes that overlapped were enriched in immune functions, endothelial cell regulation and cell interaction gene sets, indicating the po …
Differentially expressed genes between the high and low PLXNB2 expression groups were overlapped with PLXNB2-coexpressed genes …
Age-related secretion of grancalcin by macrophages induces skeletal stem/progenitor cell senescence during fracture healing.
Zou NY, Liu R, Huang M, Jiao YR, Wei J, Jiang Y, He WZ, Huang M, Xu YL, Liu L, Sun YC, Yang M, Guo Q, Huang Y, Su T, Xiao Y, Wang WS, Zeng C, Lei GH, Luo XH, Li CJ. Zou NY, et al. Bone Res. 2024 Jan 25;12(1):6. doi: 10.1038/s41413-023-00309-1. Bone Res. 2024. PMID: 38267422 Free PMC article.
Mechanistically, GCA binds to the plexin-B2 receptor and activates Arg2-mediated mitochondrial dysfunction, resulting in cellular senescence. Depletion of Plxnb2 in SSPCs impaired fracture healing. Administration of GCA-neutralizing antibody enhanced fracture healing in ag …
Mechanistically, GCA binds to the plexin-B2 receptor and activates Arg2-mediated mitochondrial dysfunction, resulting in cellular senescence …
114 results