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Serum soluble CD26/DPP4 titer variation is a potential prognostic biomarker in cancer therapy with a humanized anti-CD26 antibody.

Kaneko Y, Hatano R, Hirota N, Isambert N, Trillet-Lenoir V, You B, Alexandre J, Zalcman G, Valleix F, Podoll T, Umezawa Y, Takao S, Iwata S, Hosono O, Taguchi T, Yamada T, Dang NH, Ohnuma K, Angevin E, Morimoto C. Kaneko Y, et al. Among authors: podoll t. Biomark Res. 2021 Mar 23;9(1):21. doi: 10.1186/s40364-021-00273-0. Biomark Res. 2021. PMID: 33757558 Free PMC article.

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Oxidative Deamination of Emixustat by Human Vascular Adhesion Protein-1/Semicarbazide-Sensitive Amine Oxidase.

Reid MJ, Eyre R, Podoll T. Reid MJ, et al. Among authors: podoll t. Drug Metab Dispos. 2019 May;47(5):504-515. doi: 10.1124/dmd.118.085811. Epub 2019 Feb 20. Drug Metab Dispos. 2019. PMID: 30787099

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Validation and reproducibility of an LC-MS/MS method for emixustat and its three deaminated metabolites in human plasma.

Podoll T, Geisler L, Parys MV, Hanson G, Reid MJ. Podoll T, et al. Bioanalysis. 2018 Oct 16. doi: 10.4155/bio-2018-0159. Online ahead of print. Bioanalysis. 2018. PMID: 30325202

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Pharmacokinetics and Macrophage Inhibitory Cytokine-1 Pharmacodynamics of the Murine Double Minute 2 Inhibitor, Navtemadlin (KRT-232) in Fed and Fasted Healthy Subjects.

Wong S, Krejsa C, Lee D, Harris A, Simard E, Wang X, Allard M, Podoll T, O'Reilly T, Slatter JG. Wong S, et al. Among authors: podoll t. Clin Pharmacol Drug Dev. 2022 May;11(5):640-653. doi: 10.1002/cpdd.1070. Epub 2022 Feb 16. Clin Pharmacol Drug Dev. 2022. PMID: 35172043 Clinical Trial.

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Bioavailability, Biotransformation, and Excretion of the Covalent Bruton Tyrosine Kinase Inhibitor Acalabrutinib in Rats, Dogs, and Humans.

Podoll T, Pearson PG, Evarts J, Ingallinera T, Bibikova E, Sun H, Gohdes M, Cardinal K, Sanghvi M, Slatter JG. Podoll T, et al. Drug Metab Dispos. 2019 Feb;47(2):145-154. doi: 10.1124/dmd.118.084459. Epub 2018 Nov 15. Drug Metab Dispos. 2019. PMID: 30442651 Clinical Trial.

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Evaluation of the Drug-Drug Interaction Potential of Acalabrutinib and Its Active Metabolite, ACP-5862, Using a Physiologically-Based Pharmacokinetic Modeling Approach.

Zhou D, Podoll T, Xu Y, Moorthy G, Vishwanathan K, Ware J, Slatter JG, Al-Huniti N. Zhou D, et al. Among authors: podoll t. CPT Pharmacometrics Syst Pharmacol. 2019 Jul;8(7):489-499. doi: 10.1002/psp4.12408. Epub 2019 May 12. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 31044521 Free PMC article.

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Bioanalysis of emixustat (ACU-4429) in whole blood collected with volumetric absorptive microsampling by LC-MS/MS.

Miao Z, Farnham JG, Hanson G, Podoll T, Reid MJ. Miao Z, et al. Among authors: podoll t. Bioanalysis. 2015;7(16):2071-83. doi: 10.4155/bio.15.125. Bioanalysis. 2015. PMID: 26327186

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First-in-human phase 1 of YS110, a monoclonal antibody directed against CD26 in advanced CD26-expressing cancers.

Angevin E, Isambert N, Trillet-Lenoir V, You B, Alexandre J, Zalcman G, Vielh P, Farace F, Valleix F, Podoll T, Kuramochi Y, Miyashita I, Hosono O, Dang NH, Ohnuma K, Yamada T, Kaneko Y, Morimoto C. Angevin E, et al. Among authors: podoll t. Br J Cancer. 2017 Apr 25;116(9):1126-1134. doi: 10.1038/bjc.2017.62. Epub 2017 Mar 14. Br J Cancer. 2017. PMID: 28291776 Free PMC article. Clinical Trial.

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Evaluation of the Pharmacokinetics and Safety of a Single Dose of Acalabrutinib in Subjects With Hepatic Impairment.

Xu Y, Izumi R, Nguyen H, Kwan A, Kuo H, Madere J, Slatter JG, Podoll T, Vishwanathan K, Marbury T, Smith W, Preston RA, Sharma S, Ware JA. Xu Y, et al. Among authors: podoll t. J Clin Pharmacol. 2022 Jun;62(6):812-822. doi: 10.1002/jcph.2013. Epub 2022 Feb 15. J Clin Pharmacol. 2022. PMID: 34897701

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Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC.

Warmus JS, Quinn CL, Taylor C, Murphy ST, Johnson TA, Limberakis C, Ortwine D, Bronstein J, Pagano P, Knafels JD, Lightle S, Mochalkin I, Brideau R, Podoll T. Warmus JS, et al. Among authors: podoll t. Bioorg Med Chem Lett. 2012 Apr 1;22(7):2536-43. doi: 10.1016/j.bmcl.2012.01.140. Epub 2012 Feb 16. Bioorg Med Chem Lett. 2012. PMID: 22401863

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