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Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion.

Scharping NE, Rivadeneira DB, Menk AV, Vignali PDA, Ford BR, Rittenhouse NL, Peralta R, Wang Y, Wang Y, DePeaux K, Poholek AC, Delgoffe GM. Scharping NE, et al. Among authors: poholek ac. Nat Immunol. 2021 Feb;22(2):205-215. doi: 10.1038/s41590-020-00834-9. Epub 2021 Jan 4. Nat Immunol. 2021. PMID: 33398183 Free PMC article.

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Metabolic support of tumour-infiltrating regulatory T cells by lactic acid.

Watson MJ, Vignali PDA, Mullett SJ, Overacre-Delgoffe AE, Peralta RM, Grebinoski S, Menk AV, Rittenhouse NL, DePeaux K, Whetstone RD, Vignali DAA, Hand TW, Poholek AC, Morrison BM, Rothstein JD, Wendell SG, Delgoffe GM. Watson MJ, et al. Among authors: poholek ac. Nature. 2021 Mar;591(7851):645-651. doi: 10.1038/s41586-020-03045-2. Epub 2021 Feb 15. Nature. 2021. PMID: 33589820 Free PMC article.

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Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis.

Zhang S, Edwards TN, Chaudhri VK, Wu J, Cohen JA, Hirai T, Rittenhouse N, Schmitz EG, Zhou PY, McNeil BD, Yang Y, Koerber HR, Sumpter TL, Poholek AC, Davis BM, Albers KM, Singh H, Kaplan DH. Zhang S, et al. Among authors: poholek ac. Cell. 2021 Apr 15;184(8):2151-2166.e16. doi: 10.1016/j.cell.2021.03.002. Epub 2021 Mar 24. Cell. 2021. PMID: 33765440 Free PMC article.

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Tregs facilitate obesity and insulin resistance via a Blimp-1/IL-10 axis.

Beppu LY, Mooli RGR, Qu X, Marrero GJ, Finley CA, Fooks AN, Mullen ZP, Frias AB Jr, Sipula I, Xie B, Helfrich KE, Watkins SC, Poholek AC, Ramakrishnan SK, Jurczak MJ, D'Cruz LM. Beppu LY, et al. Among authors: poholek ac. JCI Insight. 2021 Feb 8;6(3):e140644. doi: 10.1172/jci.insight.140644. JCI Insight. 2021. PMID: 33351782 Free PMC article.

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The m⁶A reader IMP2 directs autoimmune inflammation through an IL-17- and TNFα-dependent C/EBP transcription factor axis.

Bechara R, Amatya N, Bailey RD, Li Y, Aggor FEY, Li DD, Jawale CV, Coleman BM, Dai N, Gokhale NS, Taylor TC, Horner SM, Poholek AC, Bansal A, Biswas PS, Gaffen SL. Bechara R, et al. Among authors: poholek ac. Sci Immunol. 2021 Jul 2;6(61):eabd1287. doi: 10.1126/sciimmunol.abd1287. Sci Immunol. 2021. PMID: 34215679 Free PMC article.

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Adaptive plasticity of IL-10⁺ and IL-35⁺ T_reg cells cooperatively promotes tumor T cell exhaustion.

Sawant DV, Yano H, Chikina M, Zhang Q, Liao M, Liu C, Callahan DJ, Sun Z, Sun T, Tabib T, Pennathur A, Corry DB, Luketich JD, Lafyatis R, Chen W, Poholek AC, Bruno TC, Workman CJ, Vignali DAA. Sawant DV, et al. Among authors: poholek ac. Nat Immunol. 2019 Jun;20(6):724-735. doi: 10.1038/s41590-019-0346-9. Epub 2019 Apr 1. Nat Immunol. 2019. PMID: 30936494 Free PMC article.

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MicroRNA-221 and -222 modulate intestinal inflammatory Th17 cell response as negative feedback regulators downstream of interleukin-23.

Mikami Y, Philips RL, Sciumè G, Petermann F, Meylan F, Nagashima H, Yao C, Davis FP, Brooks SR, Sun HW, Takahashi H, Poholek AC, Shih HY, Afzali B, Muljo SA, Hafner M, Kanno Y, O'Shea JJ. Mikami Y, et al. Among authors: poholek ac. Immunity. 2021 Mar 9;54(3):514-525.e6. doi: 10.1016/j.immuni.2021.02.015. Epub 2021 Mar 2. Immunity. 2021. PMID: 33657395 Free PMC article.

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Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation.

Johnston RJ, Poholek AC, DiToro D, Yusuf I, Eto D, Barnett B, Dent AL, Craft J, Crotty S. Johnston RJ, et al. Among authors: poholek ac. Science. 2009 Aug 21;325(5943):1006-10. doi: 10.1126/science.1175870. Epub 2009 Jul 16. Science. 2009. PMID: 19608860 Free PMC article.

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Tissue-Specific Contributions to Control of T Cell Immunity.

Poholek AC. Poholek AC. Immunohorizons. 2021 Jun 8;5(6):410-423. doi: 10.4049/immunohorizons.2000103. Immunohorizons. 2021. PMID: 34103371

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Transcriptional and epigenetic networks of helper T and innate lymphoid cells.

Shih HY, Sciumè G, Poholek AC, Vahedi G, Hirahara K, Villarino AV, Bonelli M, Bosselut R, Kanno Y, Muljo SA, O'Shea JJ. Shih HY, et al. Among authors: poholek ac. Immunol Rev. 2014 Sep;261(1):23-49. doi: 10.1111/imr.12208. Immunol Rev. 2014. PMID: 25123275 Free PMC article. Review.

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