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1995 1
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66 results

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Page 1
Rare POLN mutations confer risk for familial nasopharyngeal carcinoma through weakened Epstein-Barr virus lytic replication.
Xiao RW, Wang F, Wang TM, Zhang JB, Wu ZY, Deng CM, Liao Y, Zhou T, Yang DW, Dong SQ, Xue WQ, He YQ, Zheng XH, Li XZ, Zhang PF, Zhang SD, Hu YZ, Liu YY, Xia YF, Gao S, Mu JB, Feng L, Jia WH. Xiao RW, et al. EBioMedicine. 2022 Oct;84:104267. doi: 10.1016/j.ebiom.2022.104267. Epub 2022 Sep 15. EBioMedicine. 2022. PMID: 36116213 Free PMC article.
POLN was involved in Epstein-Barr virus (EBV) lytic replication in NPC cells in vitro. ...The three mutations were located in two pivotal functional domains and were predicted to alter the protein stability of POLN in silico. Further assays demonstrated that POLN …
POLN was involved in Epstein-Barr virus (EBV) lytic replication in NPC cells in vitro. ...The three mutations were located in two piv …
POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308.
Marini F, Kim N, Schuffert A, Wood RD. Marini F, et al. J Biol Chem. 2003 Aug 22;278(34):32014-9. doi: 10.1074/jbc.M305646200. Epub 2003 Jun 6. J Biol Chem. 2003. PMID: 12794064 Free article.
Expression analysis by northern blotting and in situ hybridization showed highest expression of full-length POLN in human and mouse testis. POLN localized to the nucleus when expressed as a enhanced green fluorescent protein (GFP)-tagged protein in human fibroblasts …
Expression analysis by northern blotting and in situ hybridization showed highest expression of full-length POLN in human and mouse t …
DNA polymerase POLN participates in cross-link repair and homologous recombination.
Moldovan GL, Madhavan MV, Mirchandani KD, McCaffrey RM, Vinciguerra P, D'Andrea AD. Moldovan GL, et al. Mol Cell Biol. 2010 Feb;30(4):1088-96. doi: 10.1128/MCB.01124-09. Epub 2009 Dec 7. Mol Cell Biol. 2010. PMID: 19995904 Free PMC article.
By functionally assaying its role in these processes, we unraveled an unexpected involvement of POLN in homologous recombination. Moreover, we obtained evidence for physical and functional interaction of POLN with factors belonging to the Fanconi anemia pathway, a m …
By functionally assaying its role in these processes, we unraveled an unexpected involvement of POLN in homologous recombination. Mor …
Human DNA polymerase N (POLN) is a low fidelity enzyme capable of error-free bypass of 5S-thymine glycol.
Takata K, Shimizu T, Iwai S, Wood RD. Takata K, et al. J Biol Chem. 2006 Aug 18;281(33):23445-55. doi: 10.1074/jbc.M604317200. Epub 2006 Jun 19. J Biol Chem. 2006. PMID: 16787914 Free article.
Human DNA polymerase N (POLN or pol nu) is the most recently discovered nuclear DNA polymerase in the human genome. ...The strand displacement activity of POLN was higher than exonuclease-deficient Klenow fragment. Furthermore, POLN can perform translesion sy …
Human DNA polymerase N (POLN or pol nu) is the most recently discovered nuclear DNA polymerase in the human genome. ...The strand dis …
Conserved overlapping gene arrangement, restricted expression, and biochemical activities of DNA polymerase nu (POLN).
Takata K, Tomida J, Reh S, Swanhart LM, Takata M, Hukriede NA, Wood RD. Takata K, et al. J Biol Chem. 2015 Oct 2;290(40):24278-93. doi: 10.1074/jbc.M115.677419. Epub 2015 Aug 12. J Biol Chem. 2015. PMID: 26269593 Free PMC article.
By quantitative analysis of mRNA expression, we found that POLN from the zebrafish Danio rerio is expressed predominantly in testis. POLN is not detectably expressed in zebrafish embryos or in mouse embryonic stem cells. ...HAUS3 is broadly expressed in embryonic an …
By quantitative analysis of mRNA expression, we found that POLN from the zebrafish Danio rerio is expressed predominantly in testis. …
Evidence for the involvement of human DNA polymerase N in the repair of DNA interstrand cross-links.
Zietlow L, Smith LA, Bessho M, Bessho T. Zietlow L, et al. Biochemistry. 2009 Dec 15;48(49):11817-24. doi: 10.1021/bi9015346. Biochemistry. 2009. PMID: 19908865 Free PMC article.
Human DNA polymerase N (PolN) is an A-family nuclear DNA polymerase whose function is unknown. This study examines the possible role of PolN in DNA repair in human cells treated with PolN-targeted siRNA. ...The MMC hypersensitivity of PolN knockdown ce …
Human DNA polymerase N (PolN) is an A-family nuclear DNA polymerase whose function is unknown. This study examines the possible role …
Cadmium-induced POLN mutations promote m6A-dependent circ_FANCA degradation via endoribonucleolytic cleavage, triggering TCA cycle activation and oncogenic transformation.
Hao H, Wang W, Li Y, Shao Y, Yang Y, Cui J, Li B, Huang L. Hao H, et al. J Hazard Mater. 2026 Feb 15;504:141268. doi: 10.1016/j.jhazmat.2026.141268. Epub 2026 Jan 26. J Hazard Mater. 2026. PMID: 41616622
We found that Cd induced mutagenesis in DNA polymerase Nu (POLN), resulting in pronounced downregulation of circ_FANCA-a key event that enhances malignant transformation. Mechanistic studies revealed that POLN mutations promoted the recognition of N6-methyladenosine …
We found that Cd induced mutagenesis in DNA polymerase Nu (POLN), resulting in pronounced downregulation of circ_FANCA-a key event th …
Analysis of DNA polymerase ν function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance.
Takata KI, Reh S, Yousefzadeh MJ, Zelazowski MJ, Bhetawal S, Trono D, Lowery MG, Sandoval M, Takata Y, Lu Y, Lin K, Shen J, Kusewitt DF, McBride KM, Cole F, Wood RD. Takata KI, et al. PLoS Genet. 2017 Jun 1;13(6):e1006818. doi: 10.1371/journal.pgen.1006818. eCollection 2017 Jun. PLoS Genet. 2017. PMID: 28570559 Free PMC article.
DNA polymerase nu (pol nu), encoded by the POLN gene, is an A-family DNA polymerase in vertebrates and some other animal lineages. ...We constructed multiple mouse models for Poln disruption and detected no anatomic abnormalities, alterations in lifespan, or changed …
DNA polymerase nu (pol nu), encoded by the POLN gene, is an A-family DNA polymerase in vertebrates and some other animal lineages. .. …
Evolutionary conservation of residues in vertebrate DNA polymerase N conferring low fidelity and bypass activity.
Takata K, Arana ME, Seki M, Kunkel TA, Wood RD. Takata K, et al. Nucleic Acids Res. 2010 Jun;38(10):3233-44. doi: 10.1093/nar/gkq048. Epub 2010 Feb 9. Nucleic Acids Res. 2010. PMID: 20144948 Free PMC article.
POLN is a nuclear A-family DNA polymerase encoded in vertebrate genomes. POLN has unusual fidelity and DNA lesion bypass properties, including strong strand displacement activity, low fidelity favoring incorporation of T for template G and accurate translesion synth …
POLN is a nuclear A-family DNA polymerase encoded in vertebrate genomes. POLN has unusual fidelity and DNA lesion bypass prope …
66 results