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236 results

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Page 1
POLR2A Mutation is a Poor Prognostic Marker of Cerebellopontine Angle Meningioma.
Okano A, Miyawaki S, Teranishi Y, Hongo H, Dofuku S, Ohara K, Sakai Y, Shin M, Nakatomi H, Saito N. Okano A, et al. Neurosurgery. 2024 Aug 1;95(2):275-283. doi: 10.1227/neu.0000000000002873. Epub 2024 Feb 21. Neurosurgery. 2024. PMID: 38380947
RESULTS: We detected clearly the clinical features of the CPA cases with POLR2A mutation. Compared with cases without POLR2A mutation, cases with POLR2A mutation had more meningothelial type ( P = 6.9 10 -4 ), and higher rate of recurrence ( P = .04). ...For …
RESULTS: We detected clearly the clinical features of the CPA cases with POLR2A mutation. Compared with cases without POLR2A m …
POLR2A blocks osteoclastic bone resorption and protects against osteoporosis by interacting with CREB1.
Liu C, Han Y, Zhao X, Li B, Xu L, Li D, Li G. Liu C, et al. J Cell Physiol. 2021 Jul;236(7):5134-5146. doi: 10.1002/jcp.30220. Epub 2021 Feb 17. J Cell Physiol. 2021. PMID: 33595106
Notably, the osteoclast-specific deletion of POLR2A blocks bone resorption in vivo. Furthermore, POLR2A loss-of-function suppresses estrogen deficiency-induced bone resorption. Mechanistically, POLR2A regulates the assembly of CREB1 on the regulatory elements …
Notably, the osteoclast-specific deletion of POLR2A blocks bone resorption in vivo. Furthermore, POLR2A loss-of-function suppr …
CDK9 inhibition blocks the initiation of PINK1-PRKN-mediated mitophagy by regulating the SIRT1-FOXO3-BNIP3 axis and enhances the therapeutic effects involving mitochondrial dysfunction in hepatocellular carcinoma.
Yao J, Wang J, Xu Y, Guo Q, Sun Y, Liu J, Li S, Guo Y, Wei L. Yao J, et al. Autophagy. 2022 Aug;18(8):1879-1897. doi: 10.1080/15548627.2021.2007027. Epub 2021 Dec 10. Autophagy. 2022. PMID: 34890308 Free PMC article.
All of the findings reveal that mitophagy disruption is a promising strategy for HCC treatment and OA is a potential candidate for the development of mitophagy inhibitors.Abbreviations: BNIP3: BCL2 interacting protein 3; CCCP: carbonyl cyanide p-trichloromethoxy-phenylhydrazone; …
All of the findings reveal that mitophagy disruption is a promising strategy for HCC treatment and OA is a potential candidate for the devel …
POLR2A Promotes the Proliferation of Gastric Cancer Cells by Advancing the Overall Cell Cycle Progression.
Jiang Q, Zhang J, Li F, Ma X, Wu F, Miao J, Li Q, Wang X, Sun R, Yang Y, Zhao L, Huang C. Jiang Q, et al. Front Genet. 2021 Nov 25;12:688575. doi: 10.3389/fgene.2021.688575. eCollection 2021. Front Genet. 2021. PMID: 34899822 Free PMC article.
We also found that POLR2A participated in the transcriptional regulation of cyclins and cyclin-dependent kinases (CDKs) at each stage and promoted their expression, indicated POLR2A's overall promotion of cell cycle progression. Moreover, POLR2A inhibited GC …
We also found that POLR2A participated in the transcriptional regulation of cyclins and cyclin-dependent kinases (CDKs) at each stage …
Precise targeting of POLR2A as a therapeutic strategy for human triple negative breast cancer.
Xu J, Liu Y, Li Y, Wang H, Stewart S, Van der Jeught K, Agarwal P, Zhang Y, Liu S, Zhao G, Wan J, Lu X, He X. Xu J, et al. Nat Nanotechnol. 2019 Apr;14(4):388-397. doi: 10.1038/s41565-019-0381-6. Epub 2019 Feb 25. Nat Nanotechnol. 2019. PMID: 30804480 Free PMC article.
To enhance bioavailability and improve endo/lysosomal escape of siRNA, we designed pH-activated nanoparticles for augmented cytosolic delivery of POLR2A siRNA (siPol2). Suppression of POLR2A expression with the siPol2-laden nanoparticles leads to enhanced growth red …
To enhance bioavailability and improve endo/lysosomal escape of siRNA, we designed pH-activated nanoparticles for augmented cytosolic delive …
De novo POLR2A p.(Ile457Thr) variant associated with early-onset encephalopathy and cerebellar atrophy: expanding the phenotypic spectrum.
Giacomini T, Scala M, Nobile G, Severino M, Tortora D, Nobili L, Accogli A, Torella A, Capra V, Mancardi MM, Nigro V; TUDP study group. Giacomini T, et al. Brain Dev. 2022 Aug;44(7):480-485. doi: 10.1016/j.braindev.2022.04.002. Epub 2022 Apr 20. Brain Dev. 2022. PMID: 35461703
BACKGROUND: Heterozygous POLR2A variants have been recently reported in patients with a neurodevelopmental syndrome characterized by profound infantile-onset hypotonia. POLR2A encodes the highly conserved RBP1 protein, an essential subunit of the DNA-dependent RNA p …
BACKGROUND: Heterozygous POLR2A variants have been recently reported in patients with a neurodevelopmental syndrome characterized by …
USP10 Inhibits Ferroptosis via Deubiquinating POLR2A in Head and Neck Squamous Cell Carcinoma.
Zhang D, Wang X, Lu S, Gao Y, Zhu G, Li G, Yu Z, Hou J, Yan H, Yuan W, Zhang X, Hung MC, Liu Z, Liu Y. Zhang D, et al. Adv Sci (Weinh). 2025 Jul 2:e12271. doi: 10.1002/advs.202412271. Online ahead of print. Adv Sci (Weinh). 2025. PMID: 40605431
Mechanistically, USP10 directly interacts with the largest RNA Polymerase II Subunit A (POLR2A), removes the K48- and K63-linked ubiquitin chains of POLR2A through its deubiquitinase activity and prevents ubiquitin-mediated degradation. Then, POLR2A transcrip …
Mechanistically, USP10 directly interacts with the largest RNA Polymerase II Subunit A (POLR2A), removes the K48- and K63-linked ubiq …
Bclaf1 mediates super-enhancer-driven activation of POLR2A to enhance chromatin accessibility in nitrosamine-induced esophageal carcinogenesis.
Zhou X, Zhou X, Li J, He Y, Qiu S, Xu Y, Liu Z, Yao Y, Liu J, Wen Y, Xie S, Chen J, Liu L, Ou Z, Cai C, Lin J, Lei B, Zou F. Zhou X, et al. J Hazard Mater. 2025 Jul 15;492:138218. doi: 10.1016/j.jhazmat.2025.138218. Epub 2025 Apr 8. J Hazard Mater. 2025. PMID: 40220379
Bclaf1 activates RNA polymerase II subunit POLR2A to promote chromatin accessibility through distinct transcriptional and splicing mechanisms. More specifically, cleavage under targets and tagmentation (CUT&Tag) assays revealed Bclaf1/P300/H3K27ac co-recruitment at the …
Bclaf1 activates RNA polymerase II subunit POLR2A to promote chromatin accessibility through distinct transcriptional and splicing me …
XAB2 depletion induces intron retention in POLR2A to impair global transcription and promote cellular senescence.
Hou S, Qu D, Li Y, Zhu B, Liang D, Wei X, Tang W, Zhang Q, Hao J, Guo W, Wang W, Zhao S, Wang Q, Azam S, Khan M, Zhao H, Zhang L, Lei H. Hou S, et al. Nucleic Acids Res. 2019 Sep 5;47(15):8239-8254. doi: 10.1093/nar/gkz532. Nucleic Acids Res. 2019. PMID: 31216022 Free PMC article.
Domain mapping revealed that TPR motifs 2-4 and 11 of XAB2 were critical for POLR2A expression by interacting with SNW1. Finally, we showed POLR2A mediated cell senescence caused by XAB2 deficiency. Depletion of XAB2 or POLR2A induced cell senescence by up-re …
Domain mapping revealed that TPR motifs 2-4 and 11 of XAB2 were critical for POLR2A expression by interacting with SNW1. Finally, we …
De Novo Heterozygous POLR2A Variants Cause a Neurodevelopmental Syndrome with Profound Infantile-Onset Hypotonia.
Haijes HA, Koster MJE, Rehmann H, Li D, Hakonarson H, Cappuccio G, Hancarova M, Lehalle D, Reardon W, Schaefer GB, Lehman A, van de Laar IMBH, Tesselaar CD, Turner C, Goldenberg A, Patrier S, Thevenon J, Pinelli M, Brunetti-Pierri N, Prchalová D, Havlovicová M, Vlckova M, Sedláček Z, Lopez E, Ragoussis V, Pagnamenta AT, Kini U, Vos HR, van Es RM, van Schaik RFMA, van Essen TAJ, Kibaek M, Taylor JC, Sullivan J, Shashi V, Petrovski S, Fagerberg C, Martin DM, van Gassen KLI, Pfundt R, Falk MJ, McCormick EM, Timmers HTM, van Hasselt PM. Haijes HA, et al. Am J Hum Genet. 2019 Aug 1;105(2):283-301. doi: 10.1016/j.ajhg.2019.06.016. Epub 2019 Jul 25. Am J Hum Genet. 2019. PMID: 31353023 Free PMC article.
Here, we describe sixteen individuals harboring de novo heterozygous variants in POLR2A, encoding RPB1, the largest subunit of pol II. An iterative approach combining structural evaluation and mass spectrometry analyses, the use of S. cerevisiae as a model system, and the …
Here, we describe sixteen individuals harboring de novo heterozygous variants in POLR2A, encoding RPB1, the largest subunit of pol II …
236 results