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Novel activity-based probes for N-acylethanolamine acid amidase.

Petracca R, Romeo E, Baggelaar MP, Artola M, Pontis S, Ponzano S, Overkleeft HS, van der Stelt M, Piomelli D. Petracca R, et al. Among authors: ponzano s. Chem Commun (Camb). 2017 Aug 22;53(86):11810-11813. doi: 10.1039/c7cc06838g. Chem Commun (Camb). 2017. PMID: 29035406

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Advances in the discovery of N-acylethanolamine acid amidase inhibitors.

Bandiera T, Ponzano S, Piomelli D. Bandiera T, et al. Among authors: ponzano s. Pharmacol Res. 2014 Aug;86:11-7. doi: 10.1016/j.phrs.2014.04.011. Epub 2014 May 4. Pharmacol Res. 2014. PMID: 24798679 Free PMC article. Review.

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Synthesis of the 10-oxabicyclo[5.2.1]decane framework present in bioactive natural products.

Montaña ÁM, Ponzano S, Sanasi MF, Kociok-Köhn G. Montaña ÁM, et al. Among authors: ponzano s. Org Biomol Chem. 2018 Feb 28;16(9):1557-1580. doi: 10.1039/c8ob00194d. Org Biomol Chem. 2018. PMID: 29437174

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A European regulatory perspective on cystic fibrosis: current treatments, trends in drug development and translational challenges for CFTR modulators.

Ponzano S, Nigrelli G, Fregonese L, Eichler I, Bertozzi F, Bandiera T, Galietta LJV, Papaluca M. Ponzano S, et al. Eur Respir Rev. 2018 Apr 13;27(148):170124. doi: 10.1183/16000617.0124-2017. Print 2018 Jun 30. Eur Respir Rev. 2018. PMID: 29653946 Free article. Review.

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Response to: "The Role of Quantitative Systems Pharmacology in the Design of First-in-Human Trials".

Blake K, Bonelli M, Ponzano S, Enzmann H; European Medicines Agency Committee for Human Medicinal Products “First-in-Human Guideline Drafting Group”. Blake K, et al. Among authors: ponzano s. Clin Pharmacol Ther. 2018 Nov;104(5):798. doi: 10.1002/cpt.1148. Epub 2018 Jul 14. Clin Pharmacol Ther. 2018. PMID: 30007034 No abstract available.

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Activity-Based Probe for N-Acylethanolamine Acid Amidase.

Romeo E, Ponzano S, Armirotti A, Summa M, Bertozzi F, Garau G, Bandiera T, Piomelli D. Romeo E, et al. Among authors: ponzano s. ACS Chem Biol. 2015 Sep 18;10(9):2057-2064. doi: 10.1021/acschembio.5b00197. Epub 2015 Jun 23. ACS Chem Biol. 2015. PMID: 26102511 Free PMC article.

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Design and synthesis of new antitumor agents with the 1,7-epoxycyclononane framework. Study of their anticancer action mechanism by a model compound.

Montaña ÁM, Lorenzo J, Ponzano S, Sanasi MF. Montaña ÁM, et al. Among authors: ponzano s. Bioorg Med Chem. 2018 Jul 23;26(12):3379-3398. doi: 10.1016/j.bmc.2018.05.009. Epub 2018 May 18. Bioorg Med Chem. 2018. PMID: 29784272

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Promoting Safe Early Clinical Research of Novel Drug Candidates: A European Union Regulatory Perspective.

Ponzano S, Blake K, Bonelli M, Enzmann H; European Medicines Agency Committee for Human Medicinal Products “First-in-Human Guideline Drafting Group”. Ponzano S, et al. Clin Pharmacol Ther. 2018 Apr;103(4):564-566. doi: 10.1002/cpt.899. Epub 2017 Nov 6. Clin Pharmacol Ther. 2018. PMID: 29105746 Free PMC article.

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Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase.

Romeo E, Pontis S, Ponzano S, Bonezzi F, Migliore M, Di Martino S, Summa M, Piomelli D. Romeo E, et al. Among authors: ponzano s. J Vis Exp. 2016 Nov 23;(117):54652. doi: 10.3791/54652. J Vis Exp. 2016. PMID: 27911411 Free PMC article.

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Synthesis, structure-activity, and structure-stability relationships of 2-substituted-N-(4-oxo-3-oxetanyl) N-acylethanolamine acid amidase (NAAA) inhibitors.

Vitale R, Ottonello G, Petracca R, Bertozzi SM, Ponzano S, Armirotti A, Berteotti A, Dionisi M, Cavalli A, Piomelli D, Bandiera T, Bertozzi F. Vitale R, et al. Among authors: ponzano s. ChemMedChem. 2014 Feb;9(2):323-36. doi: 10.1002/cmdc.201300416. Epub 2014 Jan 8. ChemMedChem. 2014. PMID: 24403170 Free article.

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