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189 results

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Page 1
Overexpression of POU3F2 promotes radioresistance in triple-negative breast cancer via Akt pathway activation.
Zhang H, Zheng J, Fu Y, Ling J, Liu Z, Lin X, Dong X, Sun Y, Tan T, Guo Z, Xie G. Zhang H, et al. Breast Cancer Res Treat. 2023 Apr;198(3):437-446. doi: 10.1007/s10549-023-06876-5. Epub 2023 Feb 17. Breast Cancer Res Treat. 2023. PMID: 36797433
PURPOSE: POU3F2 is associated with malignant behaviors and poor prognosis in cancer. However, the function and mechanism of POU3F2 in breast cancer remain to be elucidated. Our study aimed to explore the role of POU3F2 in triple-negative breast cancer and rad …
PURPOSE: POU3F2 is associated with malignant behaviors and poor prognosis in cancer. However, the function and mechanism of POU3F2 …
Transcription factor POU3F2 regulates TRIM8 expression contributing to cellular functions implicated in schizophrenia.
Ding C, Zhang C, Kopp R, Kuney L, Meng Q, Wang L, Xia Y, Jiang Y, Dai R, Min S, Yao WD, Wong ML, Ruan H, Liu C, Chen C. Ding C, et al. Mol Psychiatry. 2021 Jul;26(7):3444-3460. doi: 10.1038/s41380-020-00877-2. Epub 2020 Sep 14. Mol Psychiatry. 2021. PMID: 32929213 Free PMC article.
Here we report that POU3F2 regulates 42 SCZ-related genes in knockdown and RNA-sequencing experiments of human neural progenitor cells (NPCs). ...Luciferase reporter and electrophoretic mobility shift assays (EMSA) showed that POU3F2 induces TRIM8 expression by bind …
Here we report that POU3F2 regulates 42 SCZ-related genes in knockdown and RNA-sequencing experiments of human neural progenitor cell …
Deficient maternal behavior in multiparous Pou3f2 mice is associated with an impaired exploratory activity.
Nasu M, Abe Y, Matsushima A, Yamanaka M, Kozuki N, Ueda S. Nasu M, et al. Behav Brain Res. 2022 Jun 3;427:113846. doi: 10.1016/j.bbr.2022.113846. Epub 2022 Mar 16. Behav Brain Res. 2022. PMID: 35306097
Previously, we demonstrated that POU3F2 acquisition of mammal-specific polyAAs contributed to the establishment of behaviors characteristic of mammals. Here, we demonstrated that Pou3f2 mice displayed basic features required for maternal care. However, Pou3f2 …
Previously, we demonstrated that POU3F2 acquisition of mammal-specific polyAAs contributed to the establishment of behaviors characte …
Monoallelic intragenic POU3F2 variants lead to neurodevelopmental delay and hyperphagic obesity, confirming the gene's candidacy in 6q16.1 deletions.
Schönauer R, Jin W, Findeisen C, Valenzuela I, Devlin LA, Murrell J, Bedoukian EC, Pöschla L, Hantmann E, Riedhammer KM, Hoefele J, Platzer K, Biemann R, Campeau PM, Münch J, Heyne H, Hoffmann A, Ghosh A, Sun W, Dong H, Noé F, Wolfrum C, Woods E, Parker MJ, Neatu R, Le Guyader G, Bruel AL, Perrin L, Spiewak H; Genomics England Research Consortium; Missotte I, Fourgeaud M, Michaud V, Lacombe D, Paolucci SA, Buchan JG, Glissmeyer M, Popp B, Blüher M, Sayer JA, Halbritter J. Schönauer R, et al. Am J Hum Genet. 2023 Jun 1;110(6):998-1007. doi: 10.1016/j.ajhg.2023.04.010. Epub 2023 May 18. Am J Hum Genet. 2023. PMID: 37207645 Free PMC article.
In a family with syndromic obesity, we identified a monoallelic truncating variant in POU3F2 (alias BRN2) encoding a neural transcription factor, which has previously been suggested as a driver of obesity and NDD in individuals with the 6q16.1 deletion. ...In a cohort with …
In a family with syndromic obesity, we identified a monoallelic truncating variant in POU3F2 (alias BRN2) encoding a neural transcrip …
POU3F2 participates in cognitive function and adult hippocampal neurogenesis via mammalian-characteristic amino acid repeats.
Hashizume K, Yamanaka M, Ueda S. Hashizume K, et al. Genes Brain Behav. 2018 Feb;17(2):118-125. doi: 10.1111/gbb.12408. Epub 2017 Aug 30. Genes Brain Behav. 2018. PMID: 28782255 Free article.
We previously generated knock-in mice (Pou3f2(delta/delta) mice) in which all three homopolymeric amino acid repeats were deleted from the Pou3f2 transactivation domain and identified phenotypic impairments in maternal behavior and pup recognition. ...In this study, …
We previously generated knock-in mice (Pou3f2(delta/delta) mice) in which all three homopolymeric amino acid repeats were deleted fro …
Reduced home cage and social activity in Pou3f2 mice.
Nasu M, Anan K, Abe Y, Kozuki N, Matsushima A, Ueda S. Nasu M, et al. Biochem Biophys Res Commun. 2020 Mar 5;523(2):411-415. doi: 10.1016/j.bbrc.2019.12.039. Epub 2019 Dec 24. Biochem Biophys Res Commun. 2020. PMID: 31870549
Pou3f2/Brn2 is a transcription factor that helps to determine the cellular identity of neocortical or hypothalamic neurons. Mammalian Pou3f2 contains three homopolymeric amino acids that are not present in amphibian Pou3f2. ...
Pou3f2/Brn2 is a transcription factor that helps to determine the cellular identity of neocortical or hypothalamic neurons. Mammalian …
Integrin alpha3 Mediates Stemness and Invasion of Glioblastoma by Regulating POU3F2.
Yao J, Wang L. Yao J, et al. Curr Protein Pept Sci. 2023;24(3):247-256. doi: 10.2174/1389203724666230224115459. Curr Protein Pept Sci. 2023. PMID: 36843258
The tumor sizes, the expression of stemness markers and epithelial-to-mesenchymal transition (EMT) markers were measured. RESULTS: Both ITGA3 and POU3F2 were upregulated in GBM tissues. Knocking down ITGA3 resulted in reduced expression of POU3F2. ...ITGA3 regulates …
The tumor sizes, the expression of stemness markers and epithelial-to-mesenchymal transition (EMT) markers were measured. RESULTS: Both ITGA …
A Novel miR-146a-POU3F2/SMARCA5 Pathway Regulates Stemness and Therapeutic Response in Glioblastoma.
Cui T, Bell EH, McElroy J, Liu K, Sebastian E, Johnson B, Gulati PM, Becker AP, Gray A, Geurts M, Subedi D, Yang L, Fleming JL, Meng W, Barnholtz-Sloan JS, Venere M, Wang QE, Robe PA, Haque SJ, Chakravarti A. Cui T, et al. Mol Cancer Res. 2021 Jan;19(1):48-60. doi: 10.1158/1541-7786.MCR-20-0353. Epub 2020 Sep 24. Mol Cancer Res. 2021. PMID: 32973101 Free article.
Collectively, our data show that miR-146a-POU3F2/SMARCA5 pathway plays a critical role in suppressing GBM-stemness and increasing TMZ-response, suggesting that POU3F2 and SMARCA5 may serve as novel therapeutic targets in GBM. IMPLICATIONS: miR-146a predicts favorabl …
Collectively, our data show that miR-146a-POU3F2/SMARCA5 pathway plays a critical role in suppressing GBM-stemness and increasing TMZ …
Direct conversion of fibroblasts to functional neurons by defined factors.
Vierbuchen T, Ostermeier A, Pang ZP, Kokubu Y, Südhof TC, Wernig M. Vierbuchen T, et al. Nature. 2010 Feb 25;463(7284):1035-41. doi: 10.1038/nature08797. Epub 2010 Jan 27. Nature. 2010. PMID: 20107439 Free PMC article.
Starting from a pool of nineteen candidate genes, we identified a combination of only three factors, Ascl1, Brn2 (also called Pou3f2) and Myt1l, that suffice to rapidly and efficiently convert mouse embryonic and postnatal fibroblasts into functional neurons in vitro. ...
Starting from a pool of nineteen candidate genes, we identified a combination of only three factors, Ascl1, Brn2 (also called Pou3f2) …
Loss of CHD1 Promotes Heterogeneous Mechanisms of Resistance to AR-Targeted Therapy via Chromatin Dysregulation.
Zhang Z, Zhou C, Li X, Barnes SD, Deng S, Hoover E, Chen CC, Lee YS, Zhang Y, Wang C, Metang LA, Wu C, Tirado CR, Johnson NA, Wongvipat J, Navrazhina K, Cao Z, Choi D, Huang CH, Linton E, Chen X, Liang Y, Mason CE, de Stanchina E, Abida W, Lujambio A, Li S, Lowe SW, Mendell JT, Malladi VS, Sawyers CL, Mu P. Zhang Z, et al. Cancer Cell. 2020 Apr 13;37(4):584-598.e11. doi: 10.1016/j.ccell.2020.03.001. Epub 2020 Mar 26. Cancer Cell. 2020. PMID: 32220301 Free PMC article.
Integrative analysis of this data, together with CRISPR-based functional screening, identified four transcription factors (NR3C1, POU3F2, NR2F1, and TBX2) that contribute to antiandrogen resistance, with associated activation of non-luminal lineage programs. ...
Integrative analysis of this data, together with CRISPR-based functional screening, identified four transcription factors (NR3C1, POU3F2 …
189 results