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Page 1
PPP1R3A inhibits osteogenesis and negatively regulates intracellular calcium levels in calcific tendinopathy.
Hu C, Ma L, Gao S, Yang MY, Mu MD, Chang L, Huang P, Ye X, Wang W, Tao X, Zhou BH, Chen W, Tang KL. Hu C, et al. iScience. 2023 Aug 30;26(10):107784. doi: 10.1016/j.isci.2023.107784. eCollection 2023 Oct 20. iScience. 2023. PMID: 37876608 Free PMC article.
In this study, we elucidate the role of PPP1R3A in CT. A significant decrease in PPP1R3A expression was observed in CT patient tissues, which was further confirmed in tissues from a CT-induced rat model. ...Overexpression of SERCA2 and knockdown of Piezo1 decreased …
In this study, we elucidate the role of PPP1R3A in CT. A significant decrease in PPP1R3A expression was observed in CT patient …
WWP2 and PPP1R3A are abnormally regulated in arrhythmia-induced cardiac damage.
Nie Q, Zhao J, Zhang H, Zhang D, Xie W. Nie Q, et al. 3 Biotech. 2021 Apr;11(4):185. doi: 10.1007/s13205-021-02719-6. Epub 2021 Mar 22. 3 Biotech. 2021. PMID: 33927976 Free PMC article.
Silencing of PPP1R3A, enhances the expression of WWP2 to 5.3-fold in initial stages, but remarkable variation not observed in advanced cardiac arrhythmia conditions. Our results suggest that PPP1R3A had a control over WWP2 in the initial stages of cardiac arrhythmia …
Silencing of PPP1R3A, enhances the expression of WWP2 to 5.3-fold in initial stages, but remarkable variation not observed in advance …
Loss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes Atrial Fibrillation.
Alsina KM, Hulsurkar M, Brandenburg S, Kownatzki-Danger D, Lenz C, Urlaub H, Abu-Taha I, Kamler M, Chiang DY, Lahiri SK, Reynolds JO, Quick AP, Scott L Jr, Word TA, Gelves MD, Heck AJR, Li N, Dobrev D, Lehnart SE, Wehrens XHT. Alsina KM, et al. Circulation. 2019 Aug 20;140(8):681-693. doi: 10.1161/CIRCULATIONAHA.119.039642. Epub 2019 Jun 12. Circulation. 2019. PMID: 31185731 Free PMC article.
RESULTS: Proteomics identified the PP1-regulatory subunit PPP1R3A as a novel RyR2-binding partner, and coimmunoprecipitation confirmed PPP1R3A binding to RyR2 and PLN. ...CONCLUSIONS: PPP1R3A is a novel PP1-regulatory subunit within the RyR2 channel complex. …
RESULTS: Proteomics identified the PP1-regulatory subunit PPP1R3A as a novel RyR2-binding partner, and coimmunoprecipitation confirme …
Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure.
Cordero P, Parikh VN, Chin ET, Erbilgin A, Gloudemans MJ, Shang C, Huang Y, Chang AC, Smith KS, Dewey F, Zaleta K, Morley M, Brandimarto J, Glazer N, Waggott D, Pavlovic A, Zhao M, Moravec CS, Tang WHW, Skreen J, Malloy C, Hannenhalli S, Li H, Ritter S, Li M, Bernstein D, Connolly A, Hakonarson H, Lusis AJ, Margulies KB, Depaoli-Roach AA, Montgomery SB, Wheeler MT, Cappola T, Ashley EA. Cordero P, et al. Nat Commun. 2019 Jun 24;10(1):2760. doi: 10.1038/s41467-019-10591-5. Nat Commun. 2019. PMID: 31235787 Free PMC article.
RNA sequencing after PPP1R3A knockdown validates network-based predictions, and highlights metabolic pathway regulation associated with increased cardiomyocyte size and perturbed respiratory metabolism. Mice lacking PPP1R3A are protected against pressure-overload he …
RNA sequencing after PPP1R3A knockdown validates network-based predictions, and highlights metabolic pathway regulation associated wi …
Disruption of the striated muscle glycogen targeting subunit PPP1R3A of protein phosphatase 1 leads to increased weight gain, fat deposition, and development of insulin resistance.
Delibegovic M, Armstrong CG, Dobbie L, Watt PW, Smith AJ, Cohen PT. Delibegovic M, et al. Diabetes. 2003 Mar;52(3):596-604. doi: 10.2337/diabetes.52.3.596. Diabetes. 2003. PMID: 12606498
Disruption of the PPP1R3A gene encoding the glycogen targeting subunit (G(M)/R(GL)) of protein phosphatase 1 (PP1) causes substantial lowering of the glycogen synthase activity and a 10-fold decrease in the glycogen levels in skeletal muscle. ...
Disruption of the PPP1R3A gene encoding the glycogen targeting subunit (G(M)/R(GL)) of protein phosphatase 1 (PP1) causes substantial …
A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice.
Savage DB, Zhai L, Ravikumar B, Choi CS, Snaar JE, McGuire AC, Wou SE, Medina-Gomez G, Kim S, Bock CB, Segvich DM, Solanky B, Deelchand D, Vidal-Puig A, Wareham NJ, Shulman GI, Karpe F, Taylor R, Pederson BA, Roach PJ, O'Rahilly S, DePaoli-Roach AA. Savage DB, et al. PLoS Med. 2008 Jan 29;5(1):e27. doi: 10.1371/journal.pmed.0050027. PLoS Med. 2008. PMID: 18232732 Free PMC article.
We previously reported that a frameshift/premature stop mutation in PPP1R3A, the gene encoding RGL, a key regulator of muscle glycogen metabolism, was present in 1.36% of participants from a population of white individuals in the UK. ...In muscle tissue from these mice, fa …
We previously reported that a frameshift/premature stop mutation in PPP1R3A, the gene encoding RGL, a key regulator of muscle glycoge …
Differential pattern of glycogen accumulation after protein phosphatase 1 glycogen-targeting subunit PPP1R6 overexpression, compared to PPP1R3C and PPP1R3A, in skeletal muscle cells.
Montori-Grau M, Guitart M, García-Martínez C, Orozco A, Gómez-Foix AM. Montori-Grau M, et al. BMC Biochem. 2011 Nov 4;12:57. doi: 10.1186/1471-2091-12-57. BMC Biochem. 2011. PMID: 22054094 Free PMC article.
Here PPP1R6 effects on myotube glycogen metabolism, particle size and subcellular distribution are examined and compared with PPP1R3C/PTG and PPP1R3A/G(M). RESULTS: PPP1R6 overexpression activates glycogen synthase (GS), reduces its phosphorylation at Ser-641/0 and increas …
Here PPP1R6 effects on myotube glycogen metabolism, particle size and subcellular distribution are examined and compared with PPP1R3C/PTG an …
Male preponderance in early diagnosed type 2 diabetes is associated with the ARE insertion/deletion polymorphism in the PPP1R3A locus.
Doney AS, Fischer B, Cecil JE, Cohen PT, Boyle DI, Leese G, Morris AD, Palmer CN. Doney AS, et al. BMC Genet. 2003 Jun 28;4:11. doi: 10.1186/1471-2156-4-11. BMC Genet. 2003. PMID: 12831406 Free PMC article.
BACKGROUND: The ARE insertion/deletion polymorphism of PPP1R3A has been associated with variation in glycaemic parameters and prevalence of diabetes. ...When this feature was examined by the common ARE 1/1 genotype we found that the male to female ratio remained at unity w …
BACKGROUND: The ARE insertion/deletion polymorphism of PPP1R3A has been associated with variation in glycaemic parameters and prevale …
Whole-exome sequencing in maya indigenous families: variant in PPP1R3A is associated with type 2 diabetes.
Sánchez-Pozos K, Ortíz-López MG, Peña-Espinoza BI, de Los Ángeles Granados-Silvestre M, Jiménez-Jacinto V, Verleyen J, Tekola-Ayele F, Sanchez-Flores A, Menjivar M. Sánchez-Pozos K, et al. Mol Genet Genomics. 2018 Oct;293(5):1205-1216. doi: 10.1007/s00438-018-1453-2. Epub 2018 Jun 11. Mol Genet Genomics. 2018. PMID: 29948331
Four variants were identified for APOB, PPP1R3A, TPPP2, and GPR1 genes, and were further tested for association with T2D in 600 unrelated Maya in a case-control study. For the first time, rs1799999 in PPP1R3A was associated with risk of T2D in Mayan Mexican individu …
Four variants were identified for APOB, PPP1R3A, TPPP2, and GPR1 genes, and were further tested for association with T2D in 600 unrel …
Obesity modifies the effects of the Asp905Tyr variant of PPP1R3A on risk of type 2 diabetes and insulin sensitivity.
Mammarella S, Creati B, Staniscia T, Verginelli F, Manzoli L, Di Valerio A, Aceto G, Romano F, Cama G, Capani F, Consoli A, Vitacolonna E, Esposito-Del Puente A, Battista P, Della Loggia F, Mariani-Costantini R, Quon MJ, Cama A. Mammarella S, et al. Diabetes Obes Metab. 2007 Sep;9(5):759-61. doi: 10.1111/j.1463-1326.2006.00699.x. Diabetes Obes Metab. 2007. PMID: 17697067 No abstract available.
60 results