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Did you mean prdc (188 results)?
PRKDC Induces Chemoresistance in Osteosarcoma by Recruiting GDE2 to Stabilize GNAS and Activate AKT.
Zhang W, Li W, Yin C, Feng C, Liu B, Xu H, Jin X, Tu C, Li Z. Zhang W, et al. Cancer Res. 2024 Sep 4;84(17):2873-2887. doi: 10.1158/0008-5472.CAN-24-0163. Cancer Res. 2024. PMID: 38900943 Free PMC article.
Using a kinome-wide CRISPR screen, we identified PRKDC as a critical determinant of doxorubicin (DOX) sensitivity in osteosarcoma. The analysis of clinical samples demonstrated that PRKDC was hyperactivated in osteosarcoma, and functional experiments showed that the …
Using a kinome-wide CRISPR screen, we identified PRKDC as a critical determinant of doxorubicin (DOX) sensitivity in osteosarcoma. Th …
Hsa_circ_0136666 stimulates gastric cancer progression and tumor immune escape by regulating the miR-375/PRKDC Axis and PD-L1 phosphorylation.
Miao Z, Li J, Wang Y, Shi M, Gu X, Zhang X, Wei F, Tang X, Zheng L, Xing Y. Miao Z, et al. Mol Cancer. 2023 Dec 13;22(1):205. doi: 10.1186/s12943-023-01883-y. Mol Cancer. 2023. PMID: 38093288 Free PMC article.
Mechanistically, we confirmed that hsa_circ_0136666 competitively upregulated PRKDC expression by sponging miR-375-3p, regulating immune checkpoint proteins, prompting phosphorylation of PD-L1 to preventing its degradation, driving PD-L1 aggregation and suppressing immune …
Mechanistically, we confirmed that hsa_circ_0136666 competitively upregulated PRKDC expression by sponging miR-375-3p, regulating imm …
Emerging functions of PRKDC in the initiation and progression of cancer.
Yin Y, He Q, Li Y, Long J, Lei X, Li Z, Zhu W. Yin Y, et al. Tumori. 2021 Dec;107(6):483-488. doi: 10.1177/0300891620950472. Epub 2020 Aug 31. Tumori. 2021. PMID: 32867618 Review.
The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is encoded by the protein kinase, DNA-activated, catalytic polypeptide (PRKDC) gene. DNA-PKcs plays a major role in nonhomologous end joining DNA repair, and it has been identified to be an important factor in t …
The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is encoded by the protein kinase, DNA-activated, catalytic polypeptide (PRK …
LMNA-PRKDC axis enhances DNA repair and promotes chemoresistance in glioblastoma.
Saathoff MR, Chojak R, Chen RX, Kazi HA, Faisal UH, Shireman JM, Drewes N, Park CH, Fan X, Khan SA, Lazanyi I, Baisiwala S, James CD, Horbinski CM, Ahmed AU. Saathoff MR, et al. Cell Death Dis. 2025 Nov 21;17(1):50. doi: 10.1038/s41419-025-08226-3. Cell Death Dis. 2025. PMID: 41271669 Free PMC article.
Proteomic profiling and targeted immunoprecipitation revealed a distinct LMNA-PRKDC-associated DNA repair complex. Inhibition of PRKDC with the ATP-competitive inhibitor KU57788 reversed resistance, restoring TMZ sensitivity and impairing tumor growth in vivo. ...Im …
Proteomic profiling and targeted immunoprecipitation revealed a distinct LMNA-PRKDC-associated DNA repair complex. Inhibition of P …
PRKDC promotes hepatitis B virus transcription through enhancing the binding of RNA Pol II to cccDNA.
Fan Y, Liang Y, Liu Y, Fan H. Fan Y, et al. Cell Death Dis. 2022 Apr 25;13(4):404. doi: 10.1038/s41419-022-04852-3. Cell Death Dis. 2022. PMID: 35468873 Free PMC article.
By functional screening, we verified that protein kinase, DNA-activated, catalytic subunit (PRKDC) was an effective activator of HBV cccDNA transcription in HBV-infected HepG2-NTCP cells and primary human hepatocytes. Mechanismly, PRKDC interacted with POLR2A and PO …
By functional screening, we verified that protein kinase, DNA-activated, catalytic subunit (PRKDC) was an effective activator of HBV …
Circ_PRKDC knockdown promotes skin wound healing by enhancing keratinocyte migration via miR-31/FBN1 axis.
Han D, Liu W, Li G, Liu L. Han D, et al. J Mol Histol. 2021 Aug;52(4):681-691. doi: 10.1007/s10735-021-09996-8. Epub 2021 Jun 18. J Mol Histol. 2021. PMID: 34143322
In human epidermal keratinocytes (HEKa), knockdown of circ_PRKDC promoted cell migration partly through up-regulating MMP-2 and MMP9, while circ_PRKDC overexpression showed opposite effects. In a mechanical study, we confirmed that miR-31 was a target of circ_PRK …
In human epidermal keratinocytes (HEKa), knockdown of circ_PRKDC promoted cell migration partly through up-regulating MMP-2 and MMP9, …
Potential value of PRKDC as a therapeutic target and prognostic biomarker in pan-cancer.
Yang X, Yang F, Lan L, Wen N, Li H, Sun X. Yang X, et al. Medicine (Baltimore). 2022 Jul 8;101(27):e29628. doi: 10.1097/MD.0000000000029628. Medicine (Baltimore). 2022. PMID: 35801800 Free PMC article.
For the first time, this research used numerous databases to perform a pan-cancer review for PRKDC to explore the possible mechanism of PRKDC in the etiology and outcomes in various tumors. ...RESULTS: Overall, tumor tissue presented a higher degree of PRKDC …
For the first time, this research used numerous databases to perform a pan-cancer review for PRKDC to explore the possible mechanism …
PRKDC-Mediated NHEJ May Play a Crucial Role in Aneuploidy of Chromosome 8-Driven Progression of Ovarian Cancer.
Luan W, Cheng H, Xie H, Liu H, Wang Y, Wang S, Ye X, Zhu H, Tang F, Li Y, Chang X. Luan W, et al. Int J Mol Sci. 2024 Apr 28;25(9):4825. doi: 10.3390/ijms25094825. Int J Mol Sci. 2024. PMID: 38732044 Free PMC article.
Further validation through analysis of the GEO and TCGA database and survival assessment, considering both mRNA expression levels and CNV status of PRKDC, has confirmed its involvement in the progression of EOC. Further functional analysis revealed an upregulation of PR …
Further validation through analysis of the GEO and TCGA database and survival assessment, considering both mRNA expression levels and CNV st …
PRKDC is a prognostic marker for poor survival in gastric cancer patients and regulates DNA damage response.
Zhang Y, Wen GM, Wu CA, Jing ZL, Li DZ, Liu GL, Wei XX, Tang MS, Li YH, Zhong Y, Deng YJ, Yang WK. Zhang Y, et al. Pathol Res Pract. 2019 Aug;215(8):152509. doi: 10.1016/j.prp.2019.152509. Epub 2019 Jun 20. Pathol Res Pract. 2019. PMID: 31255330
DNA-Dependent Protein Kinase Catalytic Subunit (PRKDC) is a key component of the non-homologous end-joining (NHEJ) pathway. By reanalyzing transcriptome data of 80 pairs of gastric cancer tumors and the adjacent normal tissues from non-treated patients, we identified PR …
DNA-Dependent Protein Kinase Catalytic Subunit (PRKDC) is a key component of the non-homologous end-joining (NHEJ) pathway. By reanal …
Two siblings with PRKDC defect who presented with cutaneous granulomas and review of the literature.
Esenboga S, Akal C, Karaatmaca B, Erman B, Dogan S, Orhan D, Boztug K, Ayvaz D, Tezcan İ. Esenboga S, et al. Clin Immunol. 2018 Dec;197:1-5. doi: 10.1016/j.clim.2018.08.002. Epub 2018 Aug 16. Clin Immunol. 2018. PMID: 30121298 Review.
V(D)J recombination, during which recognition and repair of broken DNA chains are accomplished by non-homologous end joining pathway, is a critical process in B and T cell development.Null mutations of each enzyme or protein of this pathway result in T- B- NK+ severe combined imm …
V(D)J recombination, during which recognition and repair of broken DNA chains are accomplished by non-homologous end joining pathway, is a c …
1,820 results