Prota A[au] - Search Results

Year	Number of Results
1995	1
2000	2
2002	2
2003	1
2004	1
2005	1
2006	2
2008	1
2009	2
2010	2
2013	5
2014	4
2015	1
2016	6
2017	10
2018	10
2019	9
2020	6
2021	10
2022	4

1

Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent.

Jost M, Chen Y, Gilbert LA, Horlbeck MA, Krenning L, Menchon G, Rai A, Cho MY, Stern JJ, Prota AE, Kampmann M, Akhmanova A, Steinmetz MO, Tanenbaum ME, Weissman JS. Jost M, et al. Among authors: prota ae. Mol Cell. 2017 Oct 5;68(1):210-223.e6. doi: 10.1016/j.molcel.2017.09.012. Mol Cell. 2017. PMID: 28985505 Free PMC article.

2

Pharmaceutical-Grade Rigosertib Is a Microtubule-Destabilizing Agent.

Jost M, Chen Y, Gilbert LA, Horlbeck MA, Krenning L, Menchon G, Rai A, Cho MY, Stern JJ, Prota AE, Kampmann M, Akhmanova A, Steinmetz MO, Tanenbaum ME, Weissman JS. Jost M, et al. Among authors: prota ae. Mol Cell. 2020 Jul 2;79(1):191-198.e3. doi: 10.1016/j.molcel.2020.06.008. Mol Cell. 2020. PMID: 32619469 Free PMC article.

3

Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site.

Matthew S, Chen QY, Ratnayake R, Fermaintt CS, Lucena-Agell D, Bonato F, Prota AE, Lim ST, Wang X, Díaz JF, Risinger AL, Paul VJ, Oliva MÁ, Luesch H. Matthew S, et al. Among authors: prota ae. Proc Natl Acad Sci U S A. 2021 Mar 2;118(9):e2021847118. doi: 10.1073/pnas.2021847118. Proc Natl Acad Sci U S A. 2021. PMID: 33619102 Free PMC article.

4

Comprehensive Analysis of Binding Sites in Tubulin.

Mühlethaler T, Gioia D, Prota AE, Sharpe ME, Cavalli A, Steinmetz MO. Mühlethaler T, et al. Among authors: prota ae. Angew Chem Int Ed Engl. 2021 Jun 7;60(24):13331-13342. doi: 10.1002/anie.202100273. Epub 2021 May 5. Angew Chem Int Ed Engl. 2021. PMID: 33951246 Free PMC article.

5

Crystal Structure of a Heterotetrameric Katanin p60:p80 Complex.

Faltova L, Jiang K, Frey D, Wu Y, Capitani G, Prota AE, Akhmanova A, Steinmetz MO, Kammerer RA. Faltova L, et al. Among authors: prota ae. Structure. 2019 Sep 3;27(9):1375-1383.e3. doi: 10.1016/j.str.2019.07.002. Epub 2019 Jul 25. Structure. 2019. PMID: 31353241 Free article.

6

Structural Basis of Noscapine Activation for Tubulin Binding.

Oliva MA, Prota AE, Rodríguez-Salarichs J, Bennani YL, Jiménez-Barbero J, Bargsten K, Canales Á, Steinmetz MO, Díaz JF. Oliva MA, et al. Among authors: prota ae. J Med Chem. 2020 Aug 13;63(15):8495-8501. doi: 10.1021/acs.jmedchem.0c00855. Epub 2020 Jul 29. J Med Chem. 2020. PMID: 32657585

7

Microtubule-Targeting Agents: Strategies To Hijack the Cytoskeleton.

Steinmetz MO, Prota AE. Steinmetz MO, et al. Among authors: prota ae. Trends Cell Biol. 2018 Oct;28(10):776-792. doi: 10.1016/j.tcb.2018.05.001. Epub 2018 Jun 2. Trends Cell Biol. 2018. PMID: 29871823 Review.

8

Functional and Structural Insights into a Novel Promiscuous Ketoreductase of the Lugdunomycin Biosynthetic Pathway.

Xiao X, Elsayed SS, Wu C, van der Heul HU, Metsä-Ketelä M, Du C, Prota AE, Chen CC, Liu W, Guo RT, Abrahams JP, van Wezel GP. Xiao X, et al. Among authors: prota ae. ACS Chem Biol. 2020 Sep 18;15(9):2529-2538. doi: 10.1021/acschembio.0c00564. Epub 2020 Sep 8. ACS Chem Biol. 2020. PMID: 32840360 Free PMC article.

9

Preclinical and Early Clinical Development of PTC596, a Novel Small-Molecule Tubulin-Binding Agent.

Jernigan F, Branstrom A, Baird JD, Cao L, Dali M, Furia B, Kim MJ, O'Keefe K, Kong R, Laskin OL, Colacino JM, Pykett M, Mollin A, Sheedy J, Dumble M, Moon YC, Sheridan R, Mühlethaler T, Spiegel RJ, Prota AE, Steinmetz MO, Weetall M. Jernigan F, et al. Among authors: prota ae. Mol Cancer Ther. 2021 Oct;20(10):1846-1857. doi: 10.1158/1535-7163.MCT-20-0774. Epub 2021 Jul 26. Mol Cancer Ther. 2021. PMID: 34315764 Clinical Trial.

10

1,3-Benzodioxole-Modified Noscapine Analogues: Synthesis, Antiproliferative Activity, and Tubulin-Bound Structure.

Yong C, Devine SM, Abel AC, Tomlins SD, Muthiah D, Gao X, Callaghan R, Steinmetz MO, Prota AE, Capuano B, Scammells PJ. Yong C, et al. Among authors: prota ae. ChemMedChem. 2021 Sep 16;16(18):2882-2894. doi: 10.1002/cmdc.202100363. Epub 2021 Jul 16. ChemMedChem. 2021. PMID: 34159741

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