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Page 1
Protein tyrosine phosphatase receptor type C (PTPRC or CD45).
Al Barashdi MA, Ali A, McMullin MF, Mills K. Al Barashdi MA, et al. J Clin Pathol. 2021 Sep;74(9):548-552. doi: 10.1136/jclinpath-2020-206927. Epub 2021 May 26. J Clin Pathol. 2021. PMID: 34039664 Free PMC article. Review.
The leucocyte common antigen, protein tyrosine phosphatase receptor type C (PTPRC), also known as CD45, is a transmembrane glycoprotein, expressed on almost all haematopoietic cells except for mature erythrocytes, and is an essential regulator of T and B cell antigen recep …
The leucocyte common antigen, protein tyrosine phosphatase receptor type C (PTPRC), also known as CD45, is a transmembrane glycoprote …
PTPRC functions as a prognosis biomarker in the tumor microenvironment of cutaneous melanoma.
Li X, Yue Z, Wang D, Zhou L. Li X, et al. Sci Rep. 2023 Nov 23;13(1):20617. doi: 10.1038/s41598-023-46794-6. Sci Rep. 2023. PMID: 37996489 Free PMC article.
PTPRC expression was positively correlated with the levels of immune checkpoint molecules, and PTPRC knockdown significantly enhanced the migration, invasion, and proliferation of melanoma cells. Finally, immunohistochemical results from HPA and Real-time quantitati …
PTPRC expression was positively correlated with the levels of immune checkpoint molecules, and PTPRC knockdown significantly e …
PTPRC promoted CD8+ T cell mediated tumor immunity and drug sensitivity in breast cancer: based on pan-cancer analysis and artificial intelligence modeling of immunogenic cell death-based drug sensitivity stratification.
Li P, Wang W, Wang S, Cao G, Pan T, Huang Y, Wan H, Zhang W, Huang Y, Jin H, Wang Z. Li P, et al. Front Immunol. 2023 Jun 14;14:1145481. doi: 10.3389/fimmu.2023.1145481. eCollection 2023. Front Immunol. 2023. PMID: 37388747 Free PMC article.
Through in vitro experiments, intracellular down-regulation of PTPRC enhanced paclitaxel tolerance in triple breast cancer (TNBC) cell lines. Meanwhile, the expression level of PTPRC was positively correlated with CD8+ T cell infiltration. Furthermore, the down-regu …
Through in vitro experiments, intracellular down-regulation of PTPRC enhanced paclitaxel tolerance in triple breast cancer (TNBC) cel …
PTPRC Inhibits Ferroptosis of Osteosarcoma Cells via Blocking TFEB/FTH1 Signaling.
Shao Y, Zuo X. Shao Y, et al. Mol Biotechnol. 2024 Oct;66(10):2985-2994. doi: 10.1007/s12033-023-00914-9. Epub 2023 Oct 18. Mol Biotechnol. 2024. PMID: 37851191
Protein tyrosine phosphatase receptor type C (PTPRC) is reported to function as an oncogenic role in various cancer. However, the studies on the roles of PTPRC in osteosarcoma (OS) are limited. ...Therefore, PTPRC/TFEB/FTH1 signaling may be a potential target …
Protein tyrosine phosphatase receptor type C (PTPRC) is reported to function as an oncogenic role in various cancer. However, the stu …
Associations between PTPRC rs10919563 A/G and FCGR2A R131H polymorphisms and responsiveness to TNF blockers in rheumatoid arthritis: a meta-analysis.
Lee YH, Bae SC. Lee YH, et al. Rheumatol Int. 2016 Jun;36(6):837-44. doi: 10.1007/s00296-016-3476-5. Epub 2016 Apr 13. Rheumatol Int. 2016. PMID: 27074847 Review.
Eighteen studies (twelve on PTPRC and six on FCGR2A) from eight articles involving 3058 patients were considered in this meta-analysis. The meta-analysis showed a significant association between the PTPRC rs10919563 A allele and response to TNF-alpha blockers in RA. …
Eighteen studies (twelve on PTPRC and six on FCGR2A) from eight articles involving 3058 patients were considered in this meta-analysi …
Exploring the Pathogenesis of Psoriasis Complicated With Atherosclerosis via Microarray Data Analysis.
Su W, Zhao Y, Wei Y, Zhang X, Ji J, Yang S. Su W, et al. Front Immunol. 2021 May 27;12:667690. doi: 10.3389/fimmu.2021.667690. eCollection 2021. Front Immunol. 2021. PMID: 34122426 Free PMC article.
Finally, 16 important hub genes were identified using cytoHubba, including LYN, CSF2RB, IL1RN, RAC2, CCL5, IRF8, C1QB, MMP9, PLEK, PTPRC, FYB, BCL2A1, LCP2, CD53, NCF2 and TLR2. CONCLUSIONS: Our study reveals the common pathogenesis of psoriasis and atherosclerosis. ...
Finally, 16 important hub genes were identified using cytoHubba, including LYN, CSF2RB, IL1RN, RAC2, CCL5, IRF8, C1QB, MMP9, PLEK, PTPRC …
Upregulation of PTPRC and Interferon Response Pathways in HIV-1 Seroconverters Prior to Infection.
Li Y, Lefebvre F, Nakku-Joloba E, Ronald A, Gray G, de Bruyn G, Kiarie J, Celum C, Cameron MJ, Lingappa JR, Mackelprang RD. Li Y, et al. J Infect Dis. 2023 Mar 1;227(5):714-719. doi: 10.1093/infdis/jiac498. J Infect Dis. 2023. PMID: 36637125 Free PMC article.
We compared peripheral blood gene expression between 15 HESN and 18 seroconverters prior to infection. We found PTPRC (encoding CD45 antigen) and interferon-response pathways had significantly higher expression among individuals who went on to become seropositive and thus …
We compared peripheral blood gene expression between 15 HESN and 18 seroconverters prior to infection. We found PTPRC (encoding CD45 …
PTPRC Overexpression Predicts Poor Prognosis and Correlates with Immune Cell Infiltration in Pediatric Acute Myeloid Leukemia.
Guo G, Li B, Li Q, Li C, Guo D. Guo G, et al. Clin Lab. 2022 Jul 1;68(7). doi: 10.7754/Clin.Lab.2021.210940. Clin Lab. 2022. PMID: 35975530
CONCLUSIONS: Overexpression of PTPRC indicates poor prognosis, and its expression level is correlated with the infiltration level of activated dendritic cells. PTPRC could be a promising immunotherapy target for pediatric AML....
CONCLUSIONS: Overexpression of PTPRC indicates poor prognosis, and its expression level is correlated with the infiltration level of …
MME and PTPRC: key renal biomarkers in lupus nephritis.
Wen M, Hun M, Zhao M, He Q. Wen M, et al. PeerJ. 2024 Sep 16;12:e18070. doi: 10.7717/peerj.18070. eCollection 2024. PeerJ. 2024. PMID: 39301055 Free PMC article.
The receiver operating characteristic (ROC) curve indicated that five DEGs (PTPRC, MX1, EGR1, MME and RORC) exhibited a higher diagnostic ROC value in both the glomerulus and tubulointerstitium group. Validation of core genes using MRL/lpr mice showed that MME and PTPRC …
The receiver operating characteristic (ROC) curve indicated that five DEGs (PTPRC, MX1, EGR1, MME and RORC) exhibited a higher diagno …
JAK2 and PTPRC mRNA expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus.
Qian D, Liu L, Zhu T, Wen L, Zhu Z, Yin X, Qiu Y, Wu M, Li X, Ma J, Zhang Q, Jin L, Wang X, Xu Q, Yang S, Sheng Y, Zhang S, Zhang X. Qian D, et al. Clin Rheumatol. 2020 Feb;39(2):443-448. doi: 10.1007/s10067-019-04778-w. Epub 2019 Nov 23. Clin Rheumatol. 2020. PMID: 31760539

The mRNA expression levels of JAK2 in SLE patients were significantly higher than those in healthy controls (P = 0.005), and PTPRC mRNA expression levels were significantly decreased (P < 0.001). However, no other statistical significance was detected. ...The PTPRC

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The mRNA expression levels of JAK2 in SLE patients were significantly higher than those in healthy controls (P = 0.005), and PTPRC mR …
1,542 results