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Coupling-Condensation Strategy for the Convergent Synthesis of an Imidazole-Fused 2-Aminoquinoline NLRP3 Agonist.
Bi C, Chadwick J, Davies ML, DelMonte AJ, Geng P, Glace AW, Green RA, Gurak JA Jr, Haley MW, He BL, Inankur B, Jamison CR, Joe CL, Kolotuchin S, Lin D, Lou S, Nye J, Ortiz A, Purdum GE, Rosso VW, Shah M, Simmons EM, Stevens JM, Strotman NA, Tan Y, Zhang L. Bi C, et al. Among authors: purdum ge. J Org Chem. 2023 Jan 6;88(1):384-394. doi: 10.1021/acs.joc.2c02395. Epub 2022 Dec 14. J Org Chem. 2023. PMID: 36516991
P(III) vs P(V): A P(V) Reagent for Thiophosphoramidate Linkages and Application to an Asymmetric Synthesis of a Cyclic Dinucleotide STING Agonist.
Zheng B, Hang C, Zhu J, Purdum GE, Sezen-Edmonds M, Treitler DS, Yu M, Yuan C, Zhu Y, Freitag A, Guo S, Zhu G, Hritzko B, Paulson J, Shackman JG, He BL, Fu W, Tai HC, Ayers S, Park H, Eastgate MD, Cohen B, Rogers A, Wang Q, Schmidt MA. Zheng B, et al. Among authors: purdum ge. J Org Chem. 2022 Feb 18;87(4):1934-1940. doi: 10.1021/acs.joc.1c01055. Epub 2021 Jul 7. J Org Chem. 2022. PMID: 34232659
Striking the right balance of intermolecular coupling for high-efficiency singlet fission.
Pensack RD, Tilley AJ, Grieco C, Purdum GE, Ostroumov EE, Granger DB, Oblinsky DG, Dean JC, Doucette GS, Asbury JB, Loo YL, Seferos DS, Anthony JE, Scholes GD. Pensack RD, et al. Among authors: purdum ge. Chem Sci. 2018 Jun 1;9(29):6240-6259. doi: 10.1039/c8sc00293b. eCollection 2018 Aug 7. Chem Sci. 2018. PMID: 30090312 Free PMC article.
Computationally aided design of a high-performance organic semiconductor: the development of a universal crystal engineering core.
Petty AJ 2nd, Ai Q, Sorli JC, Haneef HF, Purdum GE, Boehm A, Granger DB, Gu K, Rubinger CPL, Parkin SR, Graham KR, Jurchescu OD, Loo YL, Risko C, Anthony JE. Petty AJ 2nd, et al. Among authors: purdum ge. Chem Sci. 2019 Oct 7;10(45):10543-10549. doi: 10.1039/c9sc02930c. eCollection 2019 Dec 7. Chem Sci. 2019. PMID: 32055377 Free PMC article.