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Organic Anion Transporting Polypeptide Inhibition Dramatically Increases Plasma Exposure but not Pharmacodynamic Effect nor Inferred Hepatic Intracellular Exposure of Firsocostat.
Kirby BJ, Lutz JD, Yue MS, Garrison KL, Qin AR, Ampaw L, Beysen C, Myers RP, Kearney BP, Mathias A. Kirby BJ, et al. Among authors: qin ar. Clin Pharmacol Ther. 2021 May;109(5):1334-1341. doi: 10.1002/cpt.2105. Epub 2020 Nov 25. Clin Pharmacol Ther. 2021. PMID: 33141923 Clinical Trial.
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