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Trimeric purine nucleoside phosphorylase: exploring postulated one-third-of-the-sites binding in the transition state.
Wielgus-Kutrowska B, Breer K, Hashimoto M, Hikishima S, Yokomatsu T, Narczyk M, Dyzma A, Girstun A, Staroń K, Bzowska A. Wielgus-Kutrowska B, et al. Bioorg Med Chem. 2012 Nov 15;20(22):6758-69. doi: 10.1016/j.bmc.2012.08.045. Epub 2012 Sep 17. Bioorg Med Chem. 2012. PMID: 23040896
Transition-state analogue inhibitors, immucillins, were reported to bind to trimeric purine nucleoside phosphorylase (PNP) with the stoichiometry of one molecule per enzyme trimer [Miles, R. W.; Tyler, P. C.; Furneaux, R. H.; Bagdassarian, C. K.; Schra …
Transition-state analogue inhibitors, immucillins, were reported to bind to trimeric purine nucleoside phosphorylase (PNP) with the stoichio …
Purine nucleoside phosphorylase from Mycobacterium tuberculosis. Analysis of inhibition by a transition-state analogue and dissection by parts.
Basso LA, Santos DS, Shi W, Furneaux RH, Tyler PC, Schramm VL, Blanchard JS. Basso LA, et al. Biochemistry. 2001 Jul 27;40(28):8196-203. doi: 10.1021/bi010584x. Biochemistry. 2001. PMID: 11444965
The structural basis for M. tuberculosis PNP inhibition by immucillin-H and by its component parts is reported in the following paper [Shi, W., Basso, L. A., Santos, D. S., Tyler, P. C., Furneaux, R. H., Blanchard, J. S., Almo, S. C., and Schramm, V. L …
The structural basis for M. tuberculosis PNP inhibition by immucillin-H and by its component parts is reported in the following paper …
Transition state structure of purine nucleoside phosphorylase and principles of atomic motion in enzymatic catalysis.
Fedorov A, Shi W, Kicska G, Fedorov E, Tyler PC, Furneaux RH, Hanson JC, Gainsford GJ, Larese JZ, Schramm VL, Almo SC. Fedorov A, et al. Biochemistry. 2001 Jan 30;40(4):853-60. doi: 10.1021/bi002499f. Biochemistry. 2001. PMID: 11170405
Immucillin-H [ImmH; (1S)-1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol] is a 23 pM inhibitor of bovine purine nucleoside phosphorylase (PNP) specifically designed as a transition state mimic [Miles, R. W., Tyler, P. C., Furneaux, R. H
Immucillin-H [ImmH; (1S)-1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol] is a 23 pM inhibitor of bovine purine nucleosid …
Structural and kinetic evidence for an extended hydrogen-bonding network in catalysis of methyl group transfer. Role of an active site asparagine residue in activation of methyl transfer by methyltransferases.
Doukov TI, Hemmi H, Drennan CL, Ragsdale SW. Doukov TI, et al. J Biol Chem. 2007 Mar 2;282(9):6609-6618. doi: 10.1074/jbc.M609828200. Epub 2006 Dec 15. J Biol Chem. 2007. PMID: 17172470 Free PMC article.
A., Tyler, P. C., Evans, G. B., Furneaux, R. H., Shi, W., Fedorov, A., Lewandowicz, A., Cahill, S. ...In MeTr, the Asn residue swings from a distant position to within H-bonding distance of the N5 atom upon CH(3)-H(4)folate binding. ...
A., Tyler, P. C., Evans, G. B., Furneaux, R. H., Shi, W., Fedorov, A., Lewandowicz, A., Cahill, S. ...In MeTr, the Asn …
Converting the guanine phosphoribosyltransferase from Giardia lamblia to a hypoxanthine-guanine phosphoribosyltransferase.
Munagala N, Sarver AE, Wang CC. Munagala N, et al. J Biol Chem. 2000 Nov 24;275(47):37072-7. doi: 10.1074/jbc.M007239200. J Biol Chem. 2000. PMID: 10976110 Free article.
Recent structural determination of GPRTase (Shi, W., Munagala, N. R., Wang, C. C., Li, C. M., Tyler, P. C., Furneaux, R. H., Grubmeyer, C., Schramm, V. ...
Recent structural determination of GPRTase (Shi, W., Munagala, N. R., Wang, C. C., Li, C. M., Tyler, P. C., Furneaux, R
Purine-less death in Plasmodium falciparum induced by immucillin-H, a transition state analogue of purine nucleoside phosphorylase.
Kicska GA, Tyler PC, Evans GB, Furneaux RH, Schramm VL, Kim K. Kicska GA, et al. J Biol Chem. 2002 Feb 1;277(5):3226-31. doi: 10.1074/jbc.M105906200. Epub 2001 Nov 12. J Biol Chem. 2002. PMID: 11706018 Free article.
Immucillins are powerful transition state analogue inhibitors of mammalian PNP and also inhibit P. falciparum PNP as illustrated in the accompanying article (Kicska, G. A., Tyler, P. C., Evans, G. B., Furneaux, R. H., Kim, K., and Schramm, V. L. (2002) J. Bio …
Immucillins are powerful transition state analogue inhibitors of mammalian PNP and also inhibit P. falciparum PNP as illustrated in the acco …
Structural rationale for the affinity of pico- and femtomolar transition state analogues of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.
Lee JE, Singh V, Evans GB, Tyler PC, Furneaux RH, Cornell KA, Riscoe MK, Schramm VL, Howell PL. Lee JE, et al. J Biol Chem. 2005 May 6;280(18):18274-82. doi: 10.1074/jbc.M414471200. Epub 2005 Mar 3. J Biol Chem. 2005. PMID: 15746096 Free article.
The companion paper describes modifications of the Immucillin and DADMe-Immucillin inhibitors to better match transition state features of MTAN and have led to 5'-thio aromatic substitutions that extend the inhibition constants to the femtomolar range (Singh, V., Evans, G. B., Le …
The companion paper describes modifications of the Immucillin and DADMe-Immucillin inhibitors to better match transition state features of M …
Transition state analogue inhibitors of purine nucleoside phosphorylase from Plasmodium falciparum.
Kicska GA, Tyler PC, Evans GB, Furneaux RH, Kim K, Schramm VL. Kicska GA, et al. J Biol Chem. 2002 Feb 1;277(5):3219-25. doi: 10.1074/jbc.M105905200. Epub 2001 Nov 13. J Biol Chem. 2002. PMID: 11707439 Free article.
Immucillins are logically designed transition-state analogue inhibitors of mammalian purine nucleoside phosphorylase (PNP) that induce purine-less death of Plasmodium falciparum in cultured erythrocytes (Kicska, G. A., Tyler, P. C., Evans, G. B., Furneaux, R. H
Immucillins are logically designed transition-state analogue inhibitors of mammalian purine nucleoside phosphorylase (PNP) that induce purin …
Iminoribitol transition state analogue inhibitors of protozoan nucleoside hydrolases.
Miles RW, Tyler PC, Evans GB, Furneaux RH, Parkin DW, Schramm VL. Miles RW, et al. Biochemistry. 1999 Oct 5;38(40):13147-54. doi: 10.1021/bi990829u. Biochemistry. 1999. PMID: 10529186
Iminoribitols that are 1-substituted with meta- and para-derivatized phenyl groups [(1S)-substituted 1, 4-dideoxy-1,4-imino-D-ribitols] are powerful inhibitors for the nonspecific nucleoside N-ribohydrolases, but are weak inhibitiors for purine-specific isozymes [Parkin, D. W., L …
Iminoribitols that are 1-substituted with meta- and para-derivatized phenyl groups [(1S)-substituted 1, 4-dideoxy-1,4-imino-D-ribitols] are …
Prediction of inhibitor binding free energies by quantum neural networks. Nucleoside analogues binding to trypanosomal nucleoside hydrolase.
Braunheim BB, Miles RW, Schramm VL, Schwartz SD. Braunheim BB, et al. Biochemistry. 1999 Dec 7;38(49):16076-83. doi: 10.1021/bi990830t. Biochemistry. 1999. PMID: 10587430
IU-nucleoside hydrolase from Crithidia fasciculata and the inhibitor molecules described previously [Miles, R. W. Tyler, P. C. Evans, G. Furneaux R. H., Parkin, D. W., and Schramm, V. ...
IU-nucleoside hydrolase from Crithidia fasciculata and the inhibitor molecules described previously [Miles, R. W. Tyler, P. C. Evans, …
11 results