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82 results

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Page 1
Pervasive mislocalization of pathogenic coding variants underlying human disorders.
Lacoste J, Haghighi M, Haider S, Reno C, Lin ZY, Segal D, Qian WW, Xiong X, Teelucksingh T, Miglietta E, Shafqat-Abbasi H, Ryder PV, Senft R, Cimini BA, Murray RR, Nyirakanani C, Hao T, McClain GG, Roth FP, Calderwood MA, Hill DE, Vidal M, Yi SS, Sahni N, Peng J, Gingras AC, Singh S, Carpenter AE, Taipale M. Lacoste J, et al. Cell. 2024 Nov 14;187(23):6725-6741.e13. doi: 10.1016/j.cell.2024.09.003. Epub 2024 Sep 30. Cell. 2024. PMID: 39353438 Free PMC article.
Cardiotropic AAV gene therapy for heart failure: a phase 1 trial.
Henry TD, Chung ES, Alvisi M, Sethna F, Murray DR, Traverse JH, Roessig L, Roberts L, Reddy S, Chen Y, Ozkan TG, Webb S, Mittal M, Ervin L, Sadek H, Mikhail S, Haghighi K, Jiang C, Samulski RJ, Kranias EG, Tretiakova AP, Hajjar RJ. Henry TD, et al. Nat Med. 2025 Nov;31(11):3845-3852. doi: 10.1038/s41591-025-04011-z. Epub 2025 Oct 21. Nat Med. 2025. PMID: 41120766 Free PMC article. Clinical Trial.
Presentation, care, and outcomes of patients with NSTEMI according to World Bank country income classification: the ACVC-EAPCI EORP NSTEMI Registry of the European Society of Cardiology.
Nadarajah R, Ludman P, Laroche C, Appelman Y, Brugaletta S, Budaj A, Bueno H, Huber K, Kunadian V, Leonardi S, Lettino M, Milasinovic D, Gale CP; NSTEMI investigator group. Nadarajah R, et al. Eur Heart J Qual Care Clin Outcomes. 2023 Sep 12;9(6):552-563. doi: 10.1093/ehjqcco/qcad008. Eur Heart J Qual Care Clin Outcomes. 2023. PMID: 36737420 Free PMC article.
In vitro Generated Megakaryocytes for the Detection of Human Platelet Antigen-Specific Alloantibodies.
Uzun G, Lucic J, Marini I, Rigoni F, Lyshy F, Haghighi O, Wolska N, Nowak-Harnau S, Althaus K, Sachs UJ, Bakchoul T. Uzun G, et al. Transfus Med Hemother. 2024 Jul 15;52(2):152-162. doi: 10.1159/000539617. eCollection 2025 Apr. Transfus Med Hemother. 2024. PMID: 40201624 Free PMC article.
Moreover, OD values in MAIPA and MAIMA showed high correlation (r = 0.96, p < 0.001). MAIMA was reactive for samples with anti-HPA-3a as well as anti-HPA-3b; however, OD values were lower compared to MAIPA. ...

Moreover, OD values in MAIPA and MAIMA showed high correlation (r = 0.96, p < 0.001). MAIMA was reactive for samples with anti-HPA

…
Oral indomethacin modifies small intestine biofilms and host-microbe interaction mediators.
Haghighi A, Tóth AS, Demeter ZO, Hutka B, Zsidai A, Lengyel L, Haghighi S, Pannier M, Le Cosquer G, Meunier ES, Ágg B, Makra N, Ostorházi E, Ligeti B, Kovács K, Kelemen Á, Jakab A, Wachtl G, Kökény G, Szabó D, Ferdinandy P, Motta JP, Vergnolle N, Gyires K, Zádori ZS. Haghighi A, et al. Life Sci. 2026 Jan 1;384:124114. doi: 10.1016/j.lfs.2025.124114. Epub 2025 Nov 26. Life Sci. 2026. PMID: 41314593 Free article.
Increased Blood Pressure Variability is Associated with More Time Spent Outside Personalized Limits of Cerebral Autoregulation in Postpartum Preeclampsia.
Kirschner M, Woolcock Martinez H, Haghighi N, Booker WA, Marshall R, Bello NA, Petersen N, Miller EC. Kirschner M, et al. Neurocrit Care. 2025 Dec;43(3):853-863. doi: 10.1007/s12028-025-02316-y. Epub 2025 Jul 8. Neurocrit Care. 2025. PMID: 40629211
The upper and lower MAPs, where curves crossed a correlation coefficient of 0.3, were considered limits of CA. We computed a Pearson correlation (R value) between BPV and percentage of time outside limits of CA. RESULTS: We analyzed data from 19 participants, all of whom …
The upper and lower MAPs, where curves crossed a correlation coefficient of 0.3, were considered limits of CA. We computed a Pearson corre …
An integrated clinical program and crowdsourcing strategy for genomic sequencing and Mendelian disease gene discovery.
Haghighi A, Krier JB, Toth-Petroczy A, Cassa CA, Frank NY, Carmichael N, Fieg E, Bjonnes A, Mohanty A, Briere LC, Lincoln S, Lucia S, Gupta VA, Söylemez O, Sutti S, Kooshesh K, Qiu H, Fay CJ, Perroni V, Valerius J, Hanna M, Frank A, Ouahed J, Snapper SB, Pantazi A, Chopra SS, Leshchiner I, Stitziel NO, Feldweg A, Mannstadt M, Loscalzo J, Sweetser DA, Liao E, Stoler JM, Nowak CB, Sanchez-Lara PA, Klein OD, Perry H, Patsopoulos NA, Raychaudhuri S, Goessling W, Green RC, Seidman CE, MacRae CA, Sunyaev SR, Maas RL, Vuzman D; Undiagnosed Diseases Network, Brigham and Women’s Hospital FaceBase Project, Brigham Genomic Medicine (BGM). Haghighi A, et al. NPJ Genom Med. 2018 Aug 13;3:21. doi: 10.1038/s41525-018-0060-9. eCollection 2018. NPJ Genom Med. 2018. PMID: 30131872 Free PMC article. Review.
Celecoxib and rofecoxib have different effects on small intestinal ischemia/reperfusion injury in rats.
László SB, Hutka B, Tóth AS, Hegyes T, Demeter ZO, Haghighi A, Wachtl G, Kelemen Á, Jakab A, Gyires K, Zádori ZS. László SB, et al. Front Pharmacol. 2024 Nov 8;15:1468579. doi: 10.3389/fphar.2024.1468579. eCollection 2024. Front Pharmacol. 2024. PMID: 39584137 Free PMC article.
The intestinal expression of cyclooxygenase-2 (COX-2) increases rapidly after mesenteric I/R, but it is still a question of debate whether selective COX-2 inhibitors can mitigate I/R-induced gut injury. ...Our results suggest that selective COX-2 inhibitors have onl …
The intestinal expression of cyclooxygenase-2 (COX-2) increases rapidly after mesenteric I/R, but it is still a question of debate wh …
Glucose-6-phosphate dehydrogenase from Leuconostoc mesenteroides. Isolation and sequence of a peptide containing an essential lysine.
Haghighi B, Flynn TG, Levy HR. Haghighi B, et al. Biochemistry. 1982 Dec 7;21(25):6415-20. doi: 10.1021/bi00268a015. Biochemistry. 1982. PMID: 6817791
Interaction of glucose-6-phosphate dehydrogenase from Leuconostoc mesenteroides with pyridoxal 5'-phosphate and sodium borohydride leads to inactivation and modification of two lysine residues per enzyme dimer that are thought to bind glucose 6-phosphate [Milhausen, M., & Lev …
Interaction of glucose-6-phosphate dehydrogenase from Leuconostoc mesenteroides with pyridoxal 5'-phosphate and sodium borohydride leads to …
82 results