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The following term was not found in PubMed: Rabavi
Page 1
HELLS regulates transcription in T-cell lymphomas by reducing unscheduled R-loops and by facilitating RNAPII progression.
Tameni A, Mallia S, Manicardi V, Donati B, Torricelli F, Vitale E, Salviato E, Gambarelli G, Muccioli S, Zanelli M, Ascani S, Martino G, Sanguedolce F, Sauta E, Tamagnini I, Puccio N, Neri A, Ciarrocchi A, Fragliasso V. Tameni A, et al. Nucleic Acids Res. 2024 Jun 24;52(11):6171-6182. doi: 10.1093/nar/gkae239. Nucleic Acids Res. 2024. PMID: 38597676 Free PMC article.
We demonstrated that HELLS, loaded at the level of intronic regions of target promoters, facilitates RNA Polymerase II (RNAPII) progression along the gene bodies by reducing the persistence of co-transcriptional R-loops and promoting DNA damage resolution. Importantly, sel …
We demonstrated that HELLS, loaded at the level of intronic regions of target promoters, facilitates RNA Polymerase II (RNAPII) progression …
Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
GBD 2023 Disease and Injury and Risk Factor Collaborators. GBD 2023 Disease and Injury and Risk Factor Collaborators. Lancet. 2025 Oct 18;406(10513):1873-1922. doi: 10.1016/S0140-6736(25)01637-X. Epub 2025 Oct 12. Lancet. 2025. PMID: 41092926 Free PMC article.
Flap Endonuclease 1 Endonucleolytically Processes RNA to Resolve R-Loops through DNA Base Excision Repair.
Laverde EE, Polyzos AA, Tsegay PP, Shaver M, Hutcheson JD, Balakrishnan L, McMurray CT, Liu Y. Laverde EE, et al. Genes (Basel). 2022 Dec 29;14(1):98. doi: 10.3390/genes14010098. Genes (Basel). 2022. PMID: 36672839 Free PMC article.
However, it remains unknown how FEN1 can process RNA to resolve an R-loop. In this study, we examined the FEN1 cleavage activity on the RNA:DNA hybrid intermediates generated during DNA lagging strand processing and BER in R-loops. ...We further demonstrated that FE …
However, it remains unknown how FEN1 can process RNA to resolve an R-loop. In this study, we examined the FEN1 cleavage activity on t …
R-loops promote trinucleotide repeat deletion through DNA base excision repair enzymatic activities.
Laverde EE, Lai Y, Leng F, Balakrishnan L, Freudenreich CH, Liu Y. Laverde EE, et al. J Biol Chem. 2020 Oct 2;295(40):13902-13913. doi: 10.1074/jbc.RA120.014161. Epub 2020 Aug 6. J Biol Chem. 2020. PMID: 32763971 Free PMC article.
Recent studies have pointed toward a role for R-loops in causing TNR expansion and deletion, and it has been shown that base excision repair (BER) can result in CAG repeat deletion from R-loops in yeast. However, it remains unknown how BER in R-loops can medi …
Recent studies have pointed toward a role for R-loops in causing TNR expansion and deletion, and it has been shown that base excision …
11 results