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A new gastric juice peptide, BPC. An overview of the stomach-stress-organoprotection hypothesis and beneficial effects of BPC.
Sikirić P, Petek M, Rucman R, Seiwerth S, Grabarević Z, Rotkvić I, Turković B, Jagić V, Mildner B, Duvnjak M, et al. Sikirić P, et al. J Physiol Paris. 1993;87(5):313-27. doi: 10.1016/0928-4257(93)90038-u. J Physiol Paris. 1993. PMID: 8298609 Review.
Such an endogenous counteraction could even be afforded by their suitable application. A new gastric juice peptide, M(r) 40,000, named BPC, was recently isolated. Herein, a 15 amino acid fragment (BPC 157), thought to be essential for its activity, has been fully character …
Such an endogenous counteraction could even be afforded by their suitable application. A new gastric juice peptide, M(r) 40,000, name …
Pentadecapeptide BPC 157 attenuates chronic amphetamine-induced behavior disturbances.
Sikiric P, Jelovac N, Jelovac-Gjeldum A, Dodig G, Staresinic M, Anic T, Zoricic I, Rak D, Perovic D, Aralica G, Buljat G, Prkacin I, Lovric-Bencic M, Separovic J, Seiwerth S, Rucman R, Petek M, Turkovic B, Ziger T, Boban-Blagaic A, Bedekovic V, Tonkic A, Babic S. Sikiric P, et al. Acta Pharmacol Sin. 2002 May;23(5):412-22. Acta Pharmacol Sin. 2002. PMID: 11978191 Free article.
METHODS: After initial application (initial single dose-regimen), amphetamine (10 mg/kg,ip) was given once daily till d 5 (continuous administration-regimen), and thereafter on d 8, 16, and 46 (intermittent administration regimen). Fo r stereotyped behavior and heightened …
METHODS: After initial application (initial single dose-regimen), amphetamine (10 mg/kg,ip) was given once daily till d 5 (continuous admini …
Therapy effect of antiulcer agents on new chronic cysteamine colon lesion in rat.
Sikiric P, Seiwerth S, Aralica G, Perovic D, Staresinic M, Anic T, Gjurasin M, Prkacin I, Separovic J, Stancic-Rokotov D, Lovric-Bencic M, Mikus D, Turkovic B, Rotkvic I, Mise S, Rucman R, Petek M, Ziger T, Sebecic B, Ivasovic Z, Jagic V, Komericki L, Balen I, Boban-Blagaic A, Sjekavica I. Sikiric P, et al. J Physiol Paris. 2001 Jan-Dec;95(1-6):283-8. doi: 10.1016/s0928-4257(01)00039-0. J Physiol Paris. 2001. PMID: 11595451
After demonstration that cysteamine induced duodenal lesions in gastrectomized rats, while a number of antiulcer drugs mitigated these lesions, it was shown that one single intrarectal (i.r.) cysteamine application produced severe colon lesions in acute studies in rats. Th …
After demonstration that cysteamine induced duodenal lesions in gastrectomized rats, while a number of antiulcer drugs mitigated these lesio …
Cysteamine-colon and cysteamine-duodenum lesions in rats. Attenuation by gastric pentadecapeptide BPC 157, cimetidine, ranitidine, atropine, omeprazole, sulphasalazine and methylprednisolone.
Sikiric P, Seiwerth S, Grabarevic Z, Balen I, Aralica G, Gjurasin M, Komericki L, Perovic D, Ziger T, Anic T, Prkacin I, Separovic J, Stancic-Rokotov D, Lovric-Bencic M, Mikus D, Staresinic M, Aralica J, DiBiaggio N, Simec Z, Turkovic B, Rotkvic I, Mise S, Rucman R, Petek M, Sebecic B, Ivasovic Z, Boban-Blagaic A, Sjekavica I. Sikiric P, et al. J Physiol Paris. 2001 Jan-Dec;95(1-6):261-70. doi: 10.1016/s0928-4257(01)00036-5. J Physiol Paris. 2001. PMID: 11595448
All of the tested antiulcer agents were applied simultaneously with cysteamine enema (8 cm from the anus, in a volume of the 1.0 ml/rat) intraperitoneally (i.p.), intragastrically (i.g.) or intrarectally (i.r.). Pentadecapeptide BPC 157 (10 microg or 10 ng/kg b.w.), given …
All of the tested antiulcer agents were applied simultaneously with cysteamine enema (8 cm from the anus, in a volume of the 1.0 ml/rat) int …