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Page 1
Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk.
Das Pradhan A, Glynn RJ, Fruchart JC, MacFadyen JG, Zaharris ES, Everett BM, Campbell SE, Oshima R, Amarenco P, Blom DJ, Brinton EA, Eckel RH, Elam MB, Felicio JS, Ginsberg HN, Goudev A, Ishibashi S, Joseph J, Kodama T, Koenig W, Leiter LA, Lorenzatti AJ, Mankovsky B, Marx N, Nordestgaard BG, Páll D, Ray KK, Santos RD, Soran H, Susekov A, Tendera M, Yokote K, Paynter NP, Buring JE, Libby P, Ridker PM; PROMINENT Investigators. Das Pradhan A, et al. N Engl J Med. 2022 Nov 24;387(21):1923-1934. doi: 10.1056/NEJMoa2210645. Epub 2022 Nov 5. N Engl J Med. 2022. PMID: 36342113 Clinical Trial.
Synthetic site-directed ligands.
Edmundson AB, Herron JN, Ely KR, He XM, Harris DL, Voss EW Jr. Edmundson AB, et al. Philos Trans R Soc Lond B Biol Sci. 1989 Jun 12;323(1217):495-509. doi: 10.1098/rstb.1989.0027. Philos Trans R Soc Lond B Biol Sci. 1989. PMID: 2569207
Peptides designed to be specific for the main cavity were incrementally constructed from minimal binding units by M. Geysen, G. Trippick, S. Rodda and their colleagues. A pentapeptide optimized for binding by this method was diffused into a crystal of the dimer and found b …
Peptides designed to be specific for the main cavity were incrementally constructed from minimal binding units by M. Geysen, G. Trippick, …
Three-dimensional structure of an immunoglobulin light-chain dimer with amyloidogenic properties.
Bourne PC, Ramsland PA, Shan L, Fan ZC, DeWitt CR, Shultz BB, Terzyan SS, Moomaw CR, Slaughter CA, Guddat LW, Edmundson AB. Bourne PC, et al. Acta Crystallogr D Biol Crystallogr. 2002 May;58(Pt 5):815-23. doi: 10.1107/s0907444902004183. Epub 2002 Apr 26. Acta Crystallogr D Biol Crystallogr. 2002. PMID: 11976493 Free article.
The X-ray structure of an immunoglobulin light-chain dimer isolated from the urine as a "Bence-Jones protein" from a patient with multiple myeloma and amyloidosis (Sea) was determined at 1.94 A resolution and refined to R and R(free) factors of 0.22 and 0.25, respec …
The X-ray structure of an immunoglobulin light-chain dimer isolated from the urine as a "Bence-Jones protein" from a patient with multiple m …
Two distinct structures of alpha-conotoxin GI in aqueous solution.
Maslennikov IV, Sobol AG, Gladky KV, Lugovskoy AA, Ostrovsky AG, Tsetlin VI, Ivanov VT, Arseniev AS. Maslennikov IV, et al. Eur J Biochem. 1998 Jun 1;254(2):238-47. doi: 10.1046/j.1432-1327.1998.2540238.x. Eur J Biochem. 1998. PMID: 9660176 Free article.
The X-ray structure of GI [Guddat, L. W., Martin, J. A., Shan, L., Edmundson, A. B. & Gray, W. R. (1996) Biochemistry 35, 11329 - 11335] has the same folding pattern as the major NMR set, the average backbone rmsd between the two structures being 0.77 A....
The X-ray structure of GI [Guddat, L. W., Martin, J. A., Shan, L., Edmundson, A. B. & Gray, W. R. (1996) Biochemistry 35, …
Structure of health risk behavior among high school students.
Basen-Engquist K, Edmundson EW, Parcel GS. Basen-Engquist K, et al. J Consult Clin Psychol. 1996 Aug;64(4):764-75. doi: 10.1037//0022-006x.64.4.764. J Consult Clin Psychol. 1996. PMID: 8803367
The authors test the contention of R. Jessor's (1977) problem behavior theory that adolescent health risk behaviors comprise a single behavioral syndrome. ...
The authors test the contention of R. Jessor's (1977) problem behavior theory that adolescent health risk behaviors comprise a …
Psychological distress and trauma in doctors providing frontline care during the COVID-19 pandemic in the United Kingdom and Ireland: a prospective longitudinal survey cohort study.
Roberts T, Daniels J, Hulme W, Hirst R, Horner D, Lyttle MD, Samuel K, Graham B, Reynard C, Barrett M, Foley J, Cronin J, Umana E, Vinagre J, Carlton E; TheTrainee Emergency Research Network (TERN); Paediatric Emergency Research in the UK and Ireland (PERUKI); Research and Audit Federation of Trainees (RAFT), Irish Trainee Emergency Research Network (ITERN and Trainee Research in Intensive Care (TRIC)); Ireland Trainee Emergency Research Network (I-TERN) Collaborators; Research and Audit Federation of Trainees (RAFT), Trainee Research in Intensive Care (TRIC) and Specialist Anaesthesia Trainee led Audit and Research Network (SATURN) Collaborators. Roberts T, et al. BMJ Open. 2021 Jul 9;11(7):e049680. doi: 10.1136/bmjopen-2021-049680. BMJ Open. 2021. PMID: 34244282 Free PMC article.
Worry of family infection due to clinical work was the factor most strongly associated with both distress (R(2)=0.06) and trauma (R(2)=0.10). CONCLUSION: Findings reflect a pattern of elevated distress at acceleration and peak, with some natural recovery. ...
Worry of family infection due to clinical work was the factor most strongly associated with both distress (R(2)=0.06) and trauma ( …
Progress in programming antibody fragments to crystallize.
Edmundson AB, Borrebaeck CA. Edmundson AB, et al. Immunotechnology. 1998 Jan;3(4):309-17. doi: 10.1016/s1380-2933(97)10002-1. Immunotechnology. 1998. PMID: 9530564
This observation evoked memories of the first description of this type of packing for human Bence-Jones (lambda chain) dimers 20 years ago (Ely K.R. et al. Biochemistry 1978;17:158-167). Reexamination of packing interactions in selected crystal systems revealed that the C …
This observation evoked memories of the first description of this type of packing for human Bence-Jones (lambda chain) dimers 20 years ago ( …
Small-angle neutron scattering study of Bence-Jones protein Mcg: comparison of structures in solution and in crystal.
Schiffer M, Stevens FJ, Westholm FA, Kim SS, Carlson RD. Schiffer M, et al. Biochemistry. 1982 Jun 8;21(12):2874-8. doi: 10.1021/bi00541a011. Biochemistry. 1982. PMID: 7104300
Small-angle neutron scattering measurements in dilute solution were performed on the Mcg Bence-Jones protein dimer, for which performed on the Mcg Bence-Jones protein dimer, for which accurate atomic coordinates have been determined by crystallographic methods [Edmundson, …
Small-angle neutron scattering measurements in dilute solution were performed on the Mcg Bence-Jones protein dimer, for which performed on t …
Comparison of the three-dimensional structures of a human Bence-Jones dimer crystallized on Earth and aboard US Space Shuttle Mission STS-95.
Terzyan SS, Bourne CR, Ramsland PA, Bourne PC, Edmundson AB. Terzyan SS, et al. J Mol Recognit. 2003 Mar-Apr;16(2):83-90. doi: 10.1002/jmr.610. J Mol Recognit. 2003. PMID: 12720277
Three-dimensional structures determined by X-ray analysis at two temperatures (100 and 293 K) were indistinguishable from those obtained from ground-based crystals. However, both the crystallographic R factor and the free R factor were slightly lower in the models d …
Three-dimensional structures determined by X-ray analysis at two temperatures (100 and 293 K) were indistinguishable from those obtained fro …
The test-retest reliability of anatomical co-ordinate axes definition for the quantification of lower extremity kinematics during running.
Sinclair J, Taylor PJ, Greenhalgh A, Edmundson CJ, Brooks D, Hobbs SJ. Sinclair J, et al. J Hum Kinet. 2012 Dec;35:15-25. doi: 10.2478/v10078-012-0075-8. Epub 2012 Dec 30. J Hum Kinet. 2012. PMID: 23487393 Free PMC article.
Ten participants completed five successful running trials at 4.0 m.s(-1) 5%. 3-D angular joint kinematics parameters from the hip, knee and ankle were collected using an eight camera motion analysis system. ...The results indicate that no significant (p>0.05) difference …
Ten participants completed five successful running trials at 4.0 m.s(-1) 5%. 3-D angular joint kinematics parameters from the hip, kn …
15 results