Autophagy-Cholesterol Axis Remodeling Supports Malignant Progression and Chemoresistance in Glioma.
Shojaei S, Behrooz AB, Naghibzadeh K, Basso J, Alizadeh J, Dehesh T, Saberi R, Bhushan B, Eshraghi M, da Silva Rosa SC, Clark C, Tomczyk MM, Cole L, Hatch G, Dolinsky VW, Yathindranath V, Miller D, Pascoe CD, Dhingra S, Srivastava A, Ravandi A, Vitorino R, Pecic S, Azarpira N, Babaei Z, Aghaei M, Ghavami S.
Shojaei S, et al.
bioRxiv [Preprint]. 2026 Jan 20:2026.01.06.697885. doi: 10.64898/2026.01.06.697885.
bioRxiv. 2026.
PMID: 41542471
Free PMC article.
Preprint.
These alterations intensified with tumor grade and were associated with upregulation of farnesyl diphosphate synthase (FDPS), linking malignant progression to cholesterol pathway remodeling. TMZ-resistant (R) glioblastoma cells exhibited epithelial-to-mesenchymal transitio …
These alterations intensified with tumor grade and were associated with upregulation of farnesyl diphosphate synthase (FDPS), linking malign …