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55 results

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Graves' disease: Clinical manifestations, immune pathogenesis (cytokines and chemokines) and therapy.
Antonelli A, Fallahi P, Elia G, Ragusa F, Paparo SR, Ruffilli I, Patrizio A, Gonnella D, Giusti C, Virili C, Centanni M, Shoenfeld Y, Ferrari SM. Antonelli A, et al. Best Pract Res Clin Endocrinol Metab. 2020 Jan;34(1):101388. doi: 10.1016/j.beem.2020.101388. Epub 2020 Feb 4. Best Pract Res Clin Endocrinol Metab. 2020. PMID: 32059832 Review.
In GD, antigen-specific therapy has been recently published, with the induction of T cell tolerance via an immunization by TSH-R peptides. In GO, rituximab and drugs targeting cytokines have been evaluated. Furthermore, teprotumumab (a human monoclonal anti-IGF-1R blocking …
In GD, antigen-specific therapy has been recently published, with the induction of T cell tolerance via an immunization by TSH-R pept …
Precision Medicine in Graves' Disease and Ophthalmopathy.
Elia G, Fallahi P, Ragusa F, Paparo SR, Mazzi V, Benvenga S, Antonelli A, Ferrari SM. Elia G, et al. Front Pharmacol. 2021 Oct 28;12:754386. doi: 10.3389/fphar.2021.754386. eCollection 2021. Front Pharmacol. 2021. PMID: 34776972 Free PMC article. Review.
TSAb start the autoimmune process stimulating the overproduction of thyroid hormones. In addition, TSAb can stimulate TSH-R expressed in fibroblasts and orbital pre-adipocytes leading to the manifestation of Graves' ophtalmopathy (GO). ...Novel discoveries in the field led …
TSAb start the autoimmune process stimulating the overproduction of thyroid hormones. In addition, TSAb can stimulate TSH-R expressed …
Novel therapies for thyroid autoimmune diseases: An update.
Ferrari SM, Fallahi P, Elia G, Ragusa F, Camastra S, Paparo SR, Giusti C, Gonnella D, Ruffilli I, Shoenfeld Y, Antonelli A. Ferrari SM, et al. Best Pract Res Clin Endocrinol Metab. 2020 Jan;34(1):101366. doi: 10.1016/j.beem.2019.101366. Epub 2019 Nov 28. Best Pract Res Clin Endocrinol Metab. 2020. PMID: 31813786 Review.
Antigen-specific therapy for GD, by inducing T cell tolerance through an immunization with TSH-R peptides, has been published. Drugs targeting cytokines [anti-TNFalpha (Etanercept), and anti-IL-6 (Tocilizumab)], and RTX (a chimeric monoclonal antibody vs. ...
Antigen-specific therapy for GD, by inducing T cell tolerance through an immunization with TSH-R peptides, has been published. Drugs …
Teprotumumab for the treatment of thyroid eye disease.
Fallahi P, Ragusa F, Paparo SR, Elia G, Balestri E, Mazzi V, Patrizio A, Botrini C, Benvenga S, Ferrari SM, Antonelli A. Fallahi P, et al. Expert Opin Biol Ther. 2023 Feb;23(2):123-131. doi: 10.1080/14712598.2023.2172328. Epub 2023 Jan 29. Expert Opin Biol Ther. 2023. PMID: 36695097
AREAS COVERED: In TED, the autoimmune process leads to production of TSH-R and IGF-1 R autoantibodies. This induces inflammatory changes in the orbital tissue, and activation of fibroblasts with accumulation of glycosaminoglycans, leading to consequent proptosis, an …
AREAS COVERED: In TED, the autoimmune process leads to production of TSH-R and IGF-1 R autoantibodies. This induces inflammato …
Cytokines as Targets of Novel Therapies for Graves' Ophthalmopathy.
Fallahi P, Ferrari SM, Elia G, Ragusa F, Paparo SR, Patrizio A, Camastra S, Miccoli M, Cavallini G, Benvenga S, Antonelli A. Fallahi P, et al. Front Endocrinol (Lausanne). 2021 Apr 16;12:654473. doi: 10.3389/fendo.2021.654473. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 33935970 Free PMC article. Review.
Graves' disease (GD) is an organ-specific autoimmune disorder of the thyroid, which is characterized by circulating TSH-receptor (TSH-R) stimulating antibodies (TSAb), leading to hyperthyroidism. Graves' ophthalmopathy (GO) is one of GD extra-thyroidal manifestations assoc …
Graves' disease (GD) is an organ-specific autoimmune disorder of the thyroid, which is characterized by circulating TSH-receptor (TSH-R …
Respiratory pattern complexity in newly-diagnosed asthmatic patients.
Enayat J, Mahdaviani SA, Rekabi M, Ghaini M, Eslamian G, Fallahi M, Ghazvineh S, Sharifinejad N, Raoufy MR, Velayati AA. Enayat J, et al. Respir Physiol Neurobiol. 2022 Jun;300:103873. doi: 10.1016/j.resp.2022.103873. Epub 2022 Feb 22. Respir Physiol Neurobiol. 2022. PMID: 35217233
Furthermore, we identified a negative correlation between CV of IBI and asthma severity (r = -0.52, p = 0.021). CONCLUSION: Here, we took a novel approach and observed increased irregularity (more complexity) in the breathing pattern of patients newly-diagnosed with asthma …
Furthermore, we identified a negative correlation between CV of IBI and asthma severity (r = -0.52, p = 0.021). CONCLUSION: Here, we …
Monoclonal antibodies for the treatment of acute lymphocytic leukemia: A literature review.
Pourmontaseri H, Habibzadeh N, Entezari S, Samadian F, Kiyani S, Taheri M, Ahmadi A, Fallahi MS, Sheikhzadeh F, Ansari A, Tamimi A, Deravi N. Pourmontaseri H, et al. Hum Antibodies. 2022;30(3):117-130. doi: 10.3233/HAB-211511. Hum Antibodies. 2022. PMID: 35662114 Review.
Monoclonal antibodies (Mabs) are the novel Food and Drug Administration (FDA) approved remedies for the relapsed/refractory (R/R) adult ALL. In this article, we aimed to review studies that investigated the efficacy and safety of Mabs on ALL. ...
Monoclonal antibodies (Mabs) are the novel Food and Drug Administration (FDA) approved remedies for the relapsed/refractory (R/R …
Robotic assisted Total Knee Arthroplasty (TKA) is not associated with increased patient satisfaction: a systematic review and meta-analysis.
Hoveidaei AH, Esmaeili S, Ghaseminejad-Raeini A, Pirahesh K, Fallahi MS, Sandiford NA, Citak M. Hoveidaei AH, et al. Int Orthop. 2024 Jul;48(7):1771-1784. doi: 10.1007/s00264-024-06206-4. Epub 2024 May 6. Int Orthop. 2024. PMID: 38705892
Statistical analysis, including odds ratio and 95% CI was performed using R software. Heterogeneity was assessed using Cochrane's Q test. RESULTS: The systematic review included 17 articles, involving 1148 patients (571 in the rTKA group and 577 in the cTKA group) assessin …
Statistical analysis, including odds ratio and 95% CI was performed using R software. Heterogeneity was assessed using Cochrane's Q t …
Physiologic Guidance of Infrainguinal Vascular Interventions Using the Pressure Wire.
Staniloae CS, Vales L, Han SY, Sloves J, Fallahi A. Staniloae CS, et al. J Invasive Cardiol. 2015 Oct;27(10):483-8. J Invasive Cardiol. 2015. PMID: 26429850 Free article.
Before and after the procedure, all subjects had an ankle-brachial index (ABI) and Duplex ultrasound evaluation, recording prelesion and in-lesion peak systolic velocity (PSV-L), and calculating a peak systolic velocity ratio (PSV-R). A Pearson R correlation coeffic …
Before and after the procedure, all subjects had an ankle-brachial index (ABI) and Duplex ultrasound evaluation, recording prelesion and in- …
Diagnostic Delay in Ankylosing Spondylitis: Related Factors and Prognostic Outcomes.
Fallahi S, Jamshidi AR. Fallahi S, et al. Arch Rheumatol. 2015 Aug 16;31(1):24-30. doi: 10.5606/ArchRheumatol.2016.5562. eCollection 2016 Mar. Arch Rheumatol. 2015. PMID: 29900990 Free PMC article.
Educational level was negatively correlated with diagnostic delay (p=0.002, r= -0.24). Diagnostic delay was correlated with Bath ankylosing spondylitis functional index (p=0.003, r=0.23), Bath ankylosing spondylitis disease activity index (p=0.026, r=0.18), A …
Educational level was negatively correlated with diagnostic delay (p=0.002, r= -0.24). Diagnostic delay was correlated with Bath anky …
55 results