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Human frame shift mutations affecting the carboxyl terminus of perilipin increase lipolysis by failing to sequester the adipose triglyceride lipase (ATGL) coactivator AB-hydrolase-containing 5 (ABHD5).
Gandotra S, Lim K, Girousse A, Saudek V, O'Rahilly S, Savage DB. Gandotra S, et al. J Biol Chem. 2011 Oct 7;286(40):34998-5006. doi: 10.1074/jbc.M111.278853. Epub 2011 Jul 12. J Biol Chem. 2011. PMID: 21757733 Free PMC article.
We recently identified two different C-terminal PLIN1 frame shift mutations (Leu-404fs and Val-398fs) in patients with a novel subtype of partial lipodystrophy, hypertriglyceridemia, severe insulin resistance, and type 2 diabetes (Gandotra, S., Le Dour, C., Bottomley, W., …
We recently identified two different C-terminal PLIN1 frame shift mutations (Leu-404fs and Val-398fs) in patients with a novel subtype of pa …
Localization of muscarinic acetylcholine receptor 2 to the intestinal crypt stem cell compartment.
Muise ED, Gandotra N, Tackett JJ, Bamdad MC, Cowles RA. Muise ED, et al. Data Brief. 2016 Dec 21;10:482-486. doi: 10.1016/j.dib.2016.12.032. eCollection 2017 Feb. Data Brief. 2016. PMID: 28054012 Free PMC article.
The data presented in this article are related to the research article entitled "Distribution of muscarinic acetylcholine receptor subtypes in the murine small intestine" (E.D. Muise, N. Gandotra, J.J. Tackett, M.C. Bamdad, R.A. Cowles, 2016) [1]. We recently demons …
The data presented in this article are related to the research article entitled "Distribution of muscarinic acetylcholine receptor subtypes …
The antidepressant sertraline provides a novel host directed therapy module for augmenting TB therapy.
Shankaran D, Singh A, Dawa S, Arumugam P, Gandotra S, Rao V. Shankaran D, et al. Elife. 2023 Jan 11;12:e64834. doi: 10.7554/eLife.64834. Elife. 2023. PMID: 36629405 Free PMC article.
While SRT alone could only arrest bacterial growth, it effectively escalated the bactericidal activities of Isoniazid (H) and Rifampicin (R) in macrophages. This strengthening of antibiotic potencies by SRT was more evident in conditions of ineffective control by these fro …
While SRT alone could only arrest bacterial growth, it effectively escalated the bactericidal activities of Isoniazid (H) and Rifampicin ( …
Video vs Direct Laryngoscopy for Tracheal Intubation After Cardiac Arrest: A Secondary Analysis of the Direct vs Video Laryngoscope Trial.
Muhs AL, Seitz KP, Qian ET, Imhoff B, Wang L, Prekker ME, Driver BE, Trent SA, Resnick-Ault D, Schauer SG, Ginde AA, Russell DW, Gandotra S, Page DB, Gaillard JP, Smith LM, Latimer AJ, Mitchell SH, Johnson NJ, Ghamande SA, White HD, Gibbs KW, Palakshappa JA, Vonderhaar DJ, Janz DR, Whitson MR, Barnes CR, Dagan A, Moskowitz A, Krishnamoorthy V, Herbert JT, April MD, Joffe AM, Walco JP, Hughes CG, Shipley K, Maiga AW, Lloyd BD, DeMasi SC, Self WH, Rice TW, Semler MW, Casey JD; Pragmatic Critical Care Research Group. Muhs AL, et al. Chest. 2025 May;167(5):1408-1415. doi: 10.1016/j.chest.2024.12.031. Epub 2025 Jan 11. Chest. 2025. PMID: 39805516 Free PMC article. Clinical Trial.
Heterogeneous Treatment Effects of Therapeutic-Dose Heparin in Patients Hospitalized for COVID-19.
Goligher EC, Lawler PR, Jensen TP, Talisa V, Berry LR, Lorenzi E, McVerry BJ, Chang CH, Leifer E, Bradbury C, Berger J, Hunt BJ, Castellucci LA, Kornblith LZ, Gordon AC, McArthur C, Webb S, Hochman J, Neal MD, Zarychanski R, Berry S, Angus DC; REMAP-CAP, ATTACC, and ACTIV-4a Investigators. Goligher EC, et al. JAMA. 2023 Apr 4;329(13):1066-1077. doi: 10.1001/jama.2023.3651. JAMA. 2023. PMID: 36942550 Free PMC article.
Profile of Obstetric Patients in Intensive Care Unit: A Retrospective Study from a Tertiary Care Center in North India.
Gupta H, Gandotra N, Mahajan R. Gupta H, et al. Indian J Crit Care Med. 2021 Apr;25(4):388-391. doi: 10.5005/jp-journals-10071-23775. Indian J Crit Care Med. 2021. PMID: 34045804 Free PMC article.
Early diagnosis and prompt treatment of high-risk obstetric patients in a dedicated obstetric ICU in tertiary hospitals can prevent severe maternal morbidity and improve maternal care. HOW TO CITE THIS ARTICLE: Gupta H, Gandotra N, Mahajan R. Profile of Obstetric Pa …
Early diagnosis and prompt treatment of high-risk obstetric patients in a dedicated obstetric ICU in tertiary hospitals can prevent severe m …
Life Orientation Test- Revised (LOT-R) Versus Academic Score in Various First Year Health Professional Students.
Dulloo P, Vedi N, Gandotra A. Dulloo P, et al. J Clin Diagn Res. 2016 Oct;10(10):CC01-CC05. doi: 10.7860/JCDR/2016/20643.8645. Epub 2016 Oct 1. J Clin Diagn Res. 2016. PMID: 27891334 Free PMC article.
AIM: To find an association of LOT-R with the academic score of health professional students and assess gender variation. ...While no statistical correlation of significance was observed for LOT-R score with that of academic score. As per gender distribution there w …
AIM: To find an association of LOT-R with the academic score of health professional students and assess gender variation. ...While no …
Nucleic Acid Quantification by Multi-Frequency Impedance Cytometry and Machine Learning.
Kokabi M, Sui J, Gandotra N, Pournadali Khamseh A, Scharfe C, Javanmard M. Kokabi M, et al. Biosensors (Basel). 2023 Feb 24;13(3):316. doi: 10.3390/bios13030316. Biosensors (Basel). 2023. PMID: 36979528 Free PMC article.
The results of the proposed regression model indicate that an R_Squared of 97% with a slope of 0.68 is achievable. Consequently, machine learning models can be a suitable, fast, and accurate method to measure nucleic acid concentration in a sample. ...
The results of the proposed regression model indicate that an R_Squared of 97% with a slope of 0.68 is achievable. Consequently, mach …
Impact of Personality Disorder on the Treatment of Psychiatric Disorders in People Receiving Methadone-Assisted Treatment.
Kidorf M, Salazzo S, Brooner RK, Peirce J, Gandotra J, Leoutsakos JM. Kidorf M, et al. J Pers Disord. 2021 Feb;35(1):114-126. doi: 10.1521/pedi_2019_33_429. Epub 2019 Mar 28. J Pers Disord. 2021. PMID: 30920940
Participants (N = 125) were enrolled in a 12-week parent study that evaluated the impact of incentives on attendance to psychiatric care. All participants had a current DSM IV-R Axis I disorder and were classified based on presence of an Axis II disorder: Axis I-only (n = …
Participants (N = 125) were enrolled in a 12-week parent study that evaluated the impact of incentives on attendance to psychiatric care. Al …
Potentiation of serotonin signaling protects against intestinal ischemia and reperfusion injury in mice.
Tackett JJ, Gandotra N, Bamdad MC, Muise ED, Cowles RA. Tackett JJ, et al. Neurogastroenterol Motil. 2019 Mar;31(3):e13498. doi: 10.1111/nmo.13498. Epub 2018 Nov 4. Neurogastroenterol Motil. 2019. PMID: 30394002
Measurements were compared between groups using t test and chi-squared test. KEY RESULTS: Mucosal injury after I/R was significantly decreased in SERTKO and SSRI-treated mice compared to WTLM at all intervals except baseline. ...CONCLUSIONS AND INFERENCES: Potentiation of …
Measurements were compared between groups using t test and chi-squared test. KEY RESULTS: Mucosal injury after I/R was significantly …
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