Distinct immunometabolic signatures in circulating immune cells define disease outcome in acute-on-chronic liver failure.
Feio-Azevedo R, Boesch M, Radenkovic S, van Melkebeke L, Smets L, Wallays M, Boeckx B, Philips G, Prata de Oliveira J, Ghorbani M, Laleman W, Meersseman P, Wilmer A, Cassiman D, van Malenstein H, Triantafyllou E, Sánchez C, Aguilar F, Nevens F, Verbeek J, Moreau R, Arroyo V, Denadai Souza A, Clària J, Lambrechts D, Ghesquière B, Korf H, van der Merwe S.
Feio-Azevedo R, et al.
Hepatology. 2025 Feb 1;81(2):509-522. doi: 10.1097/HEP.0000000000000907. Epub 2024 May 16.
Hepatology. 2025.
PMID: 38761406
Free PMC article.
Hereto, ACLF-R cMons were characterized by transcripts associated with immune and stress tolerance, including anti-inflammatory genes such as RETN and LGALS1 . Additional metabolomic and functional validation experiments implicated an elevated oxidative phosphorylation met …
Hereto, ACLF-R cMons were characterized by transcripts associated with immune and stress tolerance, including anti-inflammatory genes …