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160 results

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Page 1
Rab23 and developmental disorders.
Hor CHH, Tang BL, Goh ELK. Hor CHH, et al. Rev Neurosci. 2018 Nov 27;29(8):849-860. doi: 10.1515/revneuro-2017-0110. Rev Neurosci. 2018. PMID: 29727300 Review.
Rab23 is a conserved member of the Rab family of small GTPases that regulates membrane trafficking in eukaryotes. ...In this review, we discuss the developmental disorders associated with Rab23 and attempt to relate its cellular activities to its roles in developmen …
Rab23 is a conserved member of the Rab family of small GTPases that regulates membrane trafficking in eukaryotes. ...In this review, …
Rab23's genetic structure, function and related diseases: a review.
Zheng LQ, Chi SM, Li CX. Zheng LQ, et al. Biosci Rep. 2017 Mar 2;37(2):BSR20160410. doi: 10.1042/BSR20160410. Print 2017 Apr 30. Biosci Rep. 2017. PMID: 28104793 Free PMC article. Review.
Rab23 has been proven to play a role in membrane trafficking and protein transport in eukaryotic cells. ...In this review, we give a brief review on the functions of Rab23, summarize the involvement of Rab23 in genetic research, membrane trafficking, and pote …
Rab23 has been proven to play a role in membrane trafficking and protein transport in eukaryotic cells. ...In this review, we give a …
Rab23: what exactly does it traffic?
Wang Y, Ng EL, Tang BL. Wang Y, et al. Traffic. 2006 Jun;7(6):746-50. doi: 10.1111/j.1600-0854.2006.00416.x. Traffic. 2006. PMID: 16683919 Free article. Review.
Rab23 is the product of the gene mutated in the mouse open brain1 phenotype, which displays neural tube defects. ...We discuss these new findings and explore the myriad of possibilities whereby Rab23 may function....
Rab23 is the product of the gene mutated in the mouse open brain1 phenotype, which displays neural tube defects. ...We discuss these …
RAB23 loss-of-function mutation causes context-dependent ciliopathy in Carpenter syndrome.
Leong WY, Tung WL, Wilkie AOM, Hor CHH. Leong WY, et al. PLoS Genet. 2025 Aug 18;21(8):e1011611. doi: 10.1371/journal.pgen.1011611. eCollection 2025 Aug. PLoS Genet. 2025. PMID: 40825043 Free PMC article.
Here, we demonstrate in vivo and in vitro Rab23 loss-of-function mutants modelling CS, including Rab23 conditional knockout (CKO) mouse mutants, CS patient-derived induced pluripotent stem cells (iPSCs), and zebrafish morphants. The Rab23-CKO mutants exhibit …
Here, we demonstrate in vivo and in vitro Rab23 loss-of-function mutants modelling CS, including Rab23 conditional knockout (C …
RAB23 regulates musculoskeletal development and patterning.
Hasan MR, Koskenranta A, Alakurtti K, Takatalo M, Rice DP. Hasan MR, et al. Front Cell Dev Biol. 2023 Feb 23;11:1049131. doi: 10.3389/fcell.2023.1049131. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 36910145 Free PMC article.
RAB23 is a small GTPase which functions at the plasma membrane to regulate growth factor signaling. ...Further analysis of the skeletal phenotype of Rab23 (-/-) mice showed a close resemblance to that of Tgfbeta2 (-/-) mice, highlighting a possible role for RAB23 …
RAB23 is a small GTPase which functions at the plasma membrane to regulate growth factor signaling. ...Further analysis of the skelet …
RAB23 facilitates clathrin-coated nascent vesicle formation at the plasma membrane and modulates cell signaling.
Hasan MR, Takatalo M, Nieminen P, Rice R, Mustonen T, Rice DP. Hasan MR, et al. Cell Mol Life Sci. 2025 Apr 22;82(1):171. doi: 10.1007/s00018-025-05694-w. Cell Mol Life Sci. 2025. PMID: 40261407 Free PMC article.
We find that RAB23 interacts with beta-adaptin (AP2beta1) subunit of the clathrin adaptor protein 2 (AP-2) complex, suggesting RAB23's involvement in clathrin-dependent endocytosis at the plasma membrane. ...We normalized transferrin uptake in RAB23 knockdown …
We find that RAB23 interacts with beta-adaptin (AP2beta1) subunit of the clathrin adaptor protein 2 (AP-2) complex, suggesting RAB …
RAB23 coordinates early osteogenesis by repressing FGF10-pERK1/2 and GLI1.
Hasan MR, Takatalo M, Ma H, Rice R, Mustonen T, Rice DP. Hasan MR, et al. Elife. 2020 Jul 14;9:e55829. doi: 10.7554/eLife.55829. Elife. 2020. PMID: 32662771 Free PMC article.
To understand how RAB23 regulates skull development, we generated Rab23-deficient mice that survive to an age where skeletal development can be studied. ...Previous studies suggest that RAB23 has a role in many parts of the body during development. Yet, it is …
To understand how RAB23 regulates skull development, we generated Rab23-deficient mice that survive to an age where skeletal d …
Rab23 activities and human cancer-emerging connections and mechanisms.
Chen Y, Ng F, Tang BL. Chen Y, et al. Tumour Biol. 2016 Oct;37(10):12959-12967. doi: 10.1007/s13277-016-5207-7. Epub 2016 Jul 23. Tumour Biol. 2016. PMID: 27449041 Free article. Review.
Rab23 is ubiquitously expressed but appears to be particularly enriched in the adult brain. ...Although its exact cellular role in membrane traffic regulation remains elusive, its known role in Shh signaling, in conjunction with several recent findings, has clearly implica …
Rab23 is ubiquitously expressed but appears to be particularly enriched in the adult brain. ...Although its exact cellular role in me …
Rab23 Promotes Hepatocellular Carcinoma Cell Migration Via Rac1/TGF-beta Signaling.
Zhang L, Zhang B, You W, Li P, Kuang Y. Zhang L, et al. Pathol Oncol Res. 2020 Jan;26(1):301-306. doi: 10.1007/s12253-018-0463-z. Epub 2018 Sep 6. Pathol Oncol Res. 2020. PMID: 30191377 Free article.
We found over-expression of Rab23 promoted the Hep3B hepatocellular carcinoma cell migration, which could be reversed by Rab23 silencing. ...Silencing Rac1 significantly attenuated Rab23-induced HepG2 migration and TGF-beta. Moreover, knockdown of TGF-beta ef …
We found over-expression of Rab23 promoted the Hep3B hepatocellular carcinoma cell migration, which could be reversed by Rab23 …
Downregulation of Rab23 inhibits hepatocellular carcinoma by repressing SHH signaling pathway.
Liu SJ, Zang YW, Huang CJ, Liu YJ. Liu SJ, et al. Cancer Rep (Hoboken). 2024 Jan;7(1):e1921. doi: 10.1002/cnr2.1921. Epub 2023 Oct 26. Cancer Rep (Hoboken). 2024. PMID: 37884351 Free PMC article.
In the present study, we examined the effect of inhibiting Rab23 expression on the pathological progression of HCC. The correlation between liver Rab23 gene expression and survival probability in human HCC patients was analyzed using the TCGA database and CPTAC data …
In the present study, we examined the effect of inhibiting Rab23 expression on the pathological progression of HCC. The correlation b …
160 results