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Ligand design for human acetylcholinesterase and nicotinic acetylcholine receptors, extending beyond the conventional and canonical.

Taylor P, Shyong YJ, Samskey N, Ho KY, Radic' Z, Fenical W, Sharpless KB, Kovarik Z, Camacho-Hernandez GA. Taylor P, et al. Among authors: radic z. J Neurochem. 2021 Sep;158(6):1217-1222. doi: 10.1111/jnc.15335. Epub 2021 Mar 12. J Neurochem. 2021. PMID: 33638151 Review.

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The cholinesterases: from genes to proteins.

Taylor P, Radić Z. Taylor P, et al. Among authors: radic z. Annu Rev Pharmacol Toxicol. 1994;34:281-320. doi: 10.1146/annurev.pa.34.040194.001433. Annu Rev Pharmacol Toxicol. 1994. PMID: 8042853 Review. No abstract available.

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Covalent inhibition of hAChE by organophosphates causes homodimer dissociation through long-range allosteric effects.

Blumenthal DK, Cheng X, Fajer M, Ho KY, Rohrer J, Gerlits O, Taylor P, Juneja P, Kovalevsky A, Radić Z. Blumenthal DK, et al. Among authors: radic z. J Biol Chem. 2021 Sep;297(3):101007. doi: 10.1016/j.jbc.2021.101007. Epub 2021 Jul 27. J Biol Chem. 2021. PMID: 34324828 Free PMC article.

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Assessment of ionizable, zwitterionic oximes as reactivating antidotal agents for organophosphate exposure.

Taylor P, Yan-Jye S, Momper J, Hou W, Camacho-Hernandez GA, Radic' Z, Rosenberg Y, Kovarik Z, Sit R, Sharpless KB. Taylor P, et al. Among authors: radic z. Chem Biol Interact. 2019 Aug 1;308:194-197. doi: 10.1016/j.cbi.2019.05.015. Epub 2019 May 14. Chem Biol Interact. 2019. PMID: 31100277 Review.

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Enhancing Target Tissue Levels and Diminishing Plasma Clearance of Ionizing Zwitterionic Antidotes in Organophosphate Exposures.

Shyong YJ, Sepulveda Y, Garcia A, Samskey NM, Radic Z, Sit RK, Sharpless KB, Momper JD, Taylor P. Shyong YJ, et al. Among authors: radic z. J Pharmacol Exp Ther. 2021 Sep;378(3):315-321. doi: 10.1124/jpet.121.000715. Epub 2021 Jun 18. J Pharmacol Exp Ther. 2021. PMID: 34145064

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Limitations in current acetylcholinesterase structure-based design of oxime antidotes for organophosphate poisoning.

Kovalevsky A, Blumenthal DK, Cheng X, Taylor P, Radić Z. Kovalevsky A, et al. Among authors: radic z. Ann N Y Acad Sci. 2016 Aug;1378(1):41-49. doi: 10.1111/nyas.13128. Epub 2016 Jul 2. Ann N Y Acad Sci. 2016. PMID: 27371941 Free PMC article. Review.

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Room temperature crystallography of human acetylcholinesterase bound to a substrate analogue 4K-TMA: Towards a neutron structure.

Gerlits O, Blakeley MP, Keen DA, Radić Z, Kovalevsky A. Gerlits O, et al. Among authors: radic z. Curr Res Struct Biol. 2021 Sep 6;3:206-215. doi: 10.1016/j.crstbi.2021.08.003. eCollection 2021. Curr Res Struct Biol. 2021. PMID: 34541552 Free PMC article.

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Mechanisms of organophosphate toxicity and detoxication with emphasis on studies in Croatia.

Reiner E, Radić Z, Simeon-Rudolf V. Reiner E, et al. Among authors: radic z. Arh Hig Rada Toksikol. 2007 Sep;58(3):329-38. doi: 10.2478/v10004-007-0026-2. Arh Hig Rada Toksikol. 2007. PMID: 17913688 Free article. Review.

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Structure and regulation of expression of the acetylcholinesterase gene.

Taylor P, Li Y, Camp S, Rachinsky TL, Ekström T, Getman D, Fuentes ME, Vellom DC, Radić Z. Taylor P, et al. Among authors: radic z. Chem Biol Interact. 1993 Jun;87(1-3):199-207. doi: 10.1016/0009-2797(93)90043-x. Chem Biol Interact. 1993. PMID: 8343976 Review.

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Contemporary paradigms for cholinergic ligand design guided by biological structure.

Taylor P, Hansen SB, Talley TT, Hibbs RE, Radić Z. Taylor P, et al. Among authors: radic z. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1875-7. doi: 10.1016/j.bmcl.2003.10.072. Bioorg Med Chem Lett. 2004. PMID: 15050619 Free PMC article. Review.

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