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Trivalent nanobody-based ligands mediate powerful activation of GPVI, CLEC-2, and PEAR1 in human platelets whereas FcγRIIA requires a tetravalent ligand.
Martin EM, Clark JC, Montague SJ, Morán LA, Di Y, Bull LJ, Whittle L, Raka F, Buka RJ, Zafar I, Kardeby C, Slater A, Watson SP. Martin EM, et al. Among authors: raka f. J Thromb Haemost. 2024 Jan;22(1):271-285. doi: 10.1016/j.jtha.2023.09.026. Epub 2023 Oct 9. J Thromb Haemost. 2024. PMID: 37813196 Free article.