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Year Number of Results
2005 1
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18 results

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Page 1
Rap1gap2 regulates axon outgrowth in olfactory sensory neurons.
Sadrian B, Cheng TW, Shull O, Gong Q. Sadrian B, et al. Mol Cell Neurosci. 2012 Jul;50(3-4):272-82. doi: 10.1016/j.mcn.2012.06.003. Epub 2012 Jun 23. Mol Cell Neurosci. 2012. PMID: 22732430
This temporal pattern coincides with an early postnatal plastic period of OSN innervation refinement at the OB glomerular layer. Rap1gap2 stunts OSN axon outgrowth when overexpressed in vitro, while knock-down of Rap1gap2 transcript results in a significant increase …
This temporal pattern coincides with an early postnatal plastic period of OSN innervation refinement at the OB glomerular layer. Rap1gap2 …
Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets.
Schultess J, Danielewski O, Smolenski AP. Schultess J, et al. Blood. 2005 Apr 15;105(8):3185-92. doi: 10.1182/blood-2004-09-3605. Epub 2005 Jan 4. Blood. 2005. PMID: 15632203 Free article.
Endogenous Rap1GAP2 protein partially colocalizes with Rap1 in human platelets. In transfected cells, we show that Rap1GAP2 exhibits strong GTPase-stimulating activity toward Rap1. Rap1GAP2 is highly phosphorylated, and we have identified cGKI as a Rap1GAP …
Endogenous Rap1GAP2 protein partially colocalizes with Rap1 in human platelets. In transfected cells, we show that Rap1GAP2 ex …
Liquid-liquid phase separation-related features of PYGB/ACTR3/CCNA2/ITGB1/ATP8A1/RAP1GAP2 predict the prognosis of pancreatic cancer.
Li X, Yu R, Shi B, Chawla A, Feng X, Zhang K, Liang L. Li X, et al. J Gastrointest Oncol. 2024 Aug 31;15(4):1723-1745. doi: 10.21037/jgo-24-426. Epub 2024 Aug 22. J Gastrointest Oncol. 2024. PMID: 39279964 Free PMC article.
RESULTS: The study identified four genes linked with an increased risk of PC; that is, PYGB, ACTR3, CCNA2, and ITGB1. Conversely, ATP8A1, and RAP1GAP2 were found to provide protection against PC. These findings contributed significantly to the development of a highly preci …
RESULTS: The study identified four genes linked with an increased risk of PC; that is, PYGB, ACTR3, CCNA2, and ITGB1. Conversely, ATP8A1, an …
Cyclic nucleotide-dependent protein kinases inhibit binding of 14-3-3 to the GTPase-activating protein Rap1GAP2 in platelets.
Hoffmeister M, Riha P, Neumüller O, Danielewski O, Schultess J, Smolenski AP. Hoffmeister M, et al. J Biol Chem. 2008 Jan 25;283(4):2297-306. doi: 10.1074/jbc.M706825200. Epub 2007 Nov 26. J Biol Chem. 2008. PMID: 18039662 Free article.
GTPase-activating proteins are required to terminate signaling by Rap1, a small guanine nucleotide-binding protein that controls integrin activity and cell adhesion. Recently, we identified Rap1GAP2, a GTPase-activating protein of Rap1 in platelets. Here we show that 14-3- …
GTPase-activating proteins are required to terminate signaling by Rap1, a small guanine nucleotide-binding protein that controls integrin ac …
Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets.
Neumüller O, Hoffmeister M, Babica J, Prelle C, Gegenbauer K, Smolenski AP. Neumüller O, et al. Blood. 2009 Aug 13;114(7):1396-404. doi: 10.1182/blood-2008-05-155234. Epub 2009 Jun 15. Blood. 2009. PMID: 19528539 Free article.
We confirmed the interaction of Rap1GAP2 and Slp1 in transfected COS-1 and HeLa cells and at endogenous level in human platelets. Mapping studies showed that Rap1GAP2 binds through amino acids T524-K525-X-T527 within its C-terminus to the C2A domain of Slp1. ...
We confirmed the interaction of Rap1GAP2 and Slp1 in transfected COS-1 and HeLa cells and at endogenous level in human platelets. Map …
Differential G-alpha interaction capacities of the GoLoco motifs in Rap GTPase activating proteins.
Willard FS, Low AB, McCudden CR, Siderovski DP. Willard FS, et al. Cell Signal. 2007 Feb;19(2):428-38. doi: 10.1016/j.cellsig.2006.07.013. Epub 2006 Sep 1. Cell Signal. 2007. PMID: 16949794
GoLoco motif proteins act as guanine nucleotide dissociation inhibitors (GDIs) for G-protein alpha subunits of the adenylyl cyclase-inhibitory (Galpha(i/o)) class. Rap1GAP2 is a newly identified GoLoco motif- and RapGAP domain-containing protein, and thus is considered a p …
GoLoco motif proteins act as guanine nucleotide dissociation inhibitors (GDIs) for G-protein alpha subunits of the adenylyl cyclase-inhibito …
Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems.
Justice AE, Chittoor G, Gondalia R, Melton PE, Lim E, Grove ML, Whitsel EA, Liu CT, Cupples LA, Fernandez-Rhodes L, Guan W, Bressler J, Fornage M, Boerwinkle E, Li Y, Demerath E, Heard-Costa N, Levy D, Stewart JD, Baccarelli A, Hou L, Conneely K, Mori TA, Beilin LJ, Huang RC, Gordon-Larsen P, Howard AG, North KE. Justice AE, et al. Epigenomics. 2020 Sep;12(17):1483-1499. doi: 10.2217/epi-2019-0276. Epub 2020 Sep 9. Epigenomics. 2020. PMID: 32901515 Free PMC article.
Results & conclusion: We identified 11 CpGs that were robustly associated with one or more central adiposity trait in adults and two in adolescents, including CpG site associations near TXNIP, ADCY7, SREBF1 and RAP1GAP2 that had not previously been associated with obes …
Results & conclusion: We identified 11 CpGs that were robustly associated with one or more central adiposity trait in adults and two in …
Sex-dimorphic gene effects on survival outcomes in people with coronary artery disease.
Dungan JR, Qin X, Gregory SG, Cooper-Dehoff R, Duarte JD, Qin H, Gulati M, Taylor JY, Pepine CJ, Hauser ER, Kraus WE. Dungan JR, et al. Am Heart J Plus. 2022 May;17:100152. doi: 10.1016/j.ahjo.2022.100152. Epub 2022 Jun 14. Am Heart J Plus. 2022. PMID: 35959094 Free PMC article.
Biologically relevant candidates included rs9932462 (EMP2/TEKT5) and rs2835913 (KCNJ6) among males and rs7217169 (RAP1GAP2), rs8021816 (PRKD1), rs8133010 (PDE9A), and rs12145981 (LPGAT1) among females. ...
Biologically relevant candidates included rs9932462 (EMP2/TEKT5) and rs2835913 (KCNJ6) among males and rs7217169 (RAP1GAP2), rs802181 …
Hostility in adolescents and adults: a genome-wide association study of the Young Finns.
Merjonen P, Keltikangas-Järvinen L, Jokela M, Seppälä I, Lyytikäinen LP, Pulkki-Råback L, Kivimäki M, Elovainio M, Kettunen J, Ripatti S, Kähönen M, Viikari J, Palotie A, Peltonen L, Raitakari OT, Lehtimäki T. Merjonen P, et al. Transl Psychiatry. 2011 Jun 21;1(6):e11. doi: 10.1038/tp.2011.13. Transl Psychiatry. 2011. PMID: 22832427 Free PMC article.
Some shared suggestive genetic influence for both paranoia and cynicism was also found from chromosome 17 at 2.8 cM (SNPs rs12936442, rs894664, rs6502671, rs7216028) and chromosome 22 at 43 cM (SNPs rs7510759, rs7510924, rs7290560), with nearest genes RAP1 GTPase activating prote …
Some shared suggestive genetic influence for both paranoia and cynicism was also found from chromosome 17 at 2.8 cM (SNPs rs12936442, rs8946 …
Genome-wide interaction studies reveal sex-specific asthma risk alleles.
Myers RA, Scott NM, Gauderman WJ, Qiu W, Mathias RA, Romieu I, Levin AM, Pino-Yanes M, Graves PE, Villarreal AB, Beaty TH, Carey VJ, Croteau-Chonka DC, del Rio Navarro B, Edlund C, Hernandez-Cadena L, Navarro-Olivos E, Padhukasahasram B, Salam MT, Torgerson DG, Van den Berg DJ, Vora H, Bleecker ER, Meyers DA, Williams LK, Martinez FD, Burchard EG, Barnes KC, Gilliland FD, Weiss ST, London SJ, Raby BA, Ober C, Nicolae DL; GRAAD. Myers RA, et al. Hum Mol Genet. 2014 Oct 1;23(19):5251-9. doi: 10.1093/hmg/ddu222. Epub 2014 May 13. Hum Mol Genet. 2014. PMID: 24824216 Free PMC article.
We also identify a Latino female-specific association in RAP1GAP2. Both of these loci included single-nucleotide polymorphisms that are known expression quantitative trait loci and have been associated with asthma in independent studies. ...
We also identify a Latino female-specific association in RAP1GAP2. Both of these loci included single-nucleotide polymorphisms that a …
18 results