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Methylation of imidazoline related compounds leads to loss of α₂-adrenoceptor affinity. Synthesis and biological evaluation of selective I₁ imidazoline receptor ligands.
Schann S, Greney H, Gasparik V, Dontenwill M, Rascente C, Lacroix G, Monassier L, Bruban V, Feldman J, Ehrhardt JD, Bousquet P. Schann S, et al. Among authors: rascente c. Bioorg Med Chem. 2012 Aug 1;20(15):4710-5. doi: 10.1016/j.bmc.2012.06.008. Epub 2012 Jun 9. Bioorg Med Chem. 2012. PMID: 22750139