Notable Enhancement of Facial Scarring Following Autologous Melanocyte-Keratinocyte Transplantation and NUVB Therapy: A Case Report

Mohammad Ali Nilforoushzadeh; Maryam Nouri; Shiva Alavi; Mohammad Amir Amirkhani; Solmaz Zare; Ehsan Alavi Rad; Masoumeh Roohaninasab; Elham Behrangi; Amir Shamloo; Bahareh Maleki; Sona Zare

doi:10.34172/jlms.2022.78

Notable Enhancement of Facial Scarring Following Autologous Melanocyte-Keratinocyte Transplantation and NUVB Therapy: A Case Report

J Lasers Med Sci. 2022 Dec 28:13:e78. doi: 10.34172/jlms.2022.78. eCollection 2022.

Authors

Mohammad Ali Nilforoushzadeh^{1

2}, Maryam Nouri¹, Shiva Alavi¹, Mohammad Amir Amirkhani¹, Solmaz Zare³, Ehsan Alavi Rad⁴, Masoumeh Roohaninasab^{5

1}, Elham Behrangi^{5

1}, Amir Shamloo^{6

7}, Bahareh Maleki¹, Sona Zare^{1

6

7}

Affiliations

¹ Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.
² Skin Repair Research Center, Jordan Dermatology and Hair Transplantation Center, Tehran, Iran.
³ Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁴ Imam Khomeini Hospital Complex (IKHC), Tehran University of Medical Sciences, Tehran, Iran.
⁵ Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
⁶ Stem Cell and Regenerative Medicine Institute, Sharif University of Technology, Tehran, 11155-9161, Iran.
⁷ Nano-Bioengineering Lab, Department of Mechanical Engineering, Sharif University of Technology, Tehran, 11365- 11155, Iran.

Abstract

Introduction: There are various types of treatment targeting healing traumatic or accidental skin scars. Transplantation of skin grafts and surgical alternatives, including autologous transplantation of melanocyte-keratinocyte suspension, have also been suggested previously. This study is representing a case of previous skin graft transplantation, complaining of scar formation and discoloration on the transplanted segment. Case Presentation: The patient was a 37-year-old lady. This patient underwent melanocyte-keratinocyte suspension transplantation and narrow-band ultraviolet B (NUVB) therapy and could reach 40% re-pigmentation enhancement. This method could be introduced as an efficient and safe method of approaching facial scarring. Conclusion: This method could be introduced as an efficient and safe method of approaching facial scarring.

Keywords: Cell therapy; Melanocytes; NUVB therapy; Skin graft; Transplantation.

Publication types

Case Reports