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2001 1
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38 results

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Page 1
Raver1 links Ripk1 RNA splicing to caspase-8-mediated pyroptotic cell death, inflammation, and pathogen resistance.
Zhang B, Orning P, Lehman JW, Dinis A, Torres-Ulloa L, Elling R, Kelliher MA, Bertin J, Proulx MK, Goguen JD, Ryan L, Kandasamy RK, Espevik T, Pai AA, Fitzgerald KA, Lien E. Zhang B, et al. Proc Natl Acad Sci U S A. 2025 Feb 18;122(7):e2420802122. doi: 10.1073/pnas.2420802122. Epub 2025 Feb 13. Proc Natl Acad Sci U S A. 2025. PMID: 39946533 Free PMC article.
We show that Raver1 influences mRNA diversity primarily by repressing alternative exon inclusion. Macrophages from Raver1-deficient mice exhibit altered splicing of Ripk1. ...These responses are accompanied by reduced activation of caspase-8, Gasdermin D and E, and …
We show that Raver1 influences mRNA diversity primarily by repressing alternative exon inclusion. Macrophages from Raver1-defi …
Whole-genome CRISPR screen identifies RAVER1 as a key regulator of RIPK1-mediated inflammatory cell death, PANoptosis.
Malireddi RKS, Bynigeri RR, Mall R, Nadendla EK, Connelly JP, Pruett-Miller SM, Kanneganti TD. Malireddi RKS, et al. iScience. 2023 May 22;26(6):106938. doi: 10.1016/j.isci.2023.106938. eCollection 2023 Jun 16. iScience. 2023. PMID: 37324531 Free PMC article.
Here, we report a genome-wide CRISPR screen in macrophages that identified TAK1i-induced cell death regulators, including polypyrimidine tract-binding (PTB) protein 1 (PTBP1), a known regulator of RIPK1, and a previously unknown regulator RAVER1. RAVER1 blocked alte …
Here, we report a genome-wide CRISPR screen in macrophages that identified TAK1i-induced cell death regulators, including polypyrimidine tra …
RAVER1 hinders lethal EMT and modulates miR/RISC activity by the control of alternative splicing.
Wedler A, Bley N, Glaß M, Müller S, Rausch A, Lederer M, Urbainski J, Schian L, Obika KB, Simon T, Peters LM, Misiak C, Fuchs T, Köhn M, Jacob R, Gutschner T, Ihling C, Sinz A, Hüttelmaier S. Wedler A, et al. Nucleic Acids Res. 2024 Apr 24;52(7):3971-3988. doi: 10.1093/nar/gkae046. Nucleic Acids Res. 2024. PMID: 38300787 Free PMC article.
Whether RAVER1 solely acts in concert with PTBPs and how it affects cancer cell fate remained elusive. Here, we provide the first comprehensive investigation of RAVER1-controlled AS in cancer cell models. This reveals a pro-oncogenic role of RAVER1 in modulat …
Whether RAVER1 solely acts in concert with PTBPs and how it affects cancer cell fate remained elusive. Here, we provide the first com …
Creation of de novo cryptic splicing for ALS and FTD precision medicine.
Wilkins OG, Chien MZYJ, Wlaschin JJ, Barattucci S, Harley P, Mattedi F, Mehta PR, Pisliakova M, Ryadnov E, Keuss MJ, Thompson D, Digby H, Knez L, Simkin RL, Diaz JA, Zanovello M, Brown AL, Darbey A, Karda R, Fisher EMC, Cunningham TJ, Le Pichon CE, Ule J, Fratta P. Wilkins OG, et al. Science. 2024 Oct 4;386(6717):61-69. doi: 10.1126/science.adk2539. Epub 2024 Oct 3. Science. 2024. PMID: 39361759 Free PMC article.
Finally, we design TDP-REG vectors encoding a TDP-43/Raver1 fusion protein that rescues key pathological cryptic splicing events, paving the way for the development of precision therapies for TDP43-related disorders....
Finally, we design TDP-REG vectors encoding a TDP-43/Raver1 fusion protein that rescues key pathological cryptic splicing events, pav …
Raver1 links Ripk1 RNA splicing to caspase-8-mediated pyroptotic cell death, inflammation, and pathogen resistance.
Zhang B, Orning P, Lehman JW, Dinis A, Torres-Ulloa L, Elling R, Kelliher MA, Bertin J, Proulx MK, Ryan L, Kandasamy R, Espevik T, Pai AA, Fitzgerald KA, Lien E. Zhang B, et al. bioRxiv [Preprint]. 2024 Nov 29:2024.11.27.625707. doi: 10.1101/2024.11.27.625707. bioRxiv. 2024. Update in: Proc Natl Acad Sci U S A. 2025 Feb 18;122(7):e2420802122. doi: 10.1073/pnas.2420802122. PMID: 39651143 Free PMC article. Updated. Preprint.
These effects were triggered by Yersinia bacteria, or by restraining TAK1 or IKKbeta in the presence of LPS, TNF family members, or IFNgamma. Consequently, animals lacking Raver1 showed heightened susceptibility to Yersinia infection. Raver1 and RIPK1 also controlle …
These effects were triggered by Yersinia bacteria, or by restraining TAK1 or IKKbeta in the presence of LPS, TNF family members, or IFNgamma …
Impaired splicing machinery in craniopharyngiomas unveils PRPF8 and RAVER1 as novel biomarkers and therapeutic targets.
Fuentes-Fayos AC, G-García ME, Sánchez-Medianero T, Apps J, Flores-Martínez Á, De la Rosa-Herencia AS, Gil-Duque I, Otto G, Venegas-Moreno E, Ruiz-Valdepeñas EC, Herrera-Martínez AD, Solivera J, Gahete MD, Cano DA, Ortega R, Soto-Moreno A, Gálvez-Moreno MA, Martínez-Barberá JP, Luque RM. Fuentes-Fayos AC, et al. Acta Neuropathol Commun. 2025 Jun 28;13(1):142. doi: 10.1186/s40478-025-02040-w. Acta Neuropathol Commun. 2025. PMID: 40581690 Free PMC article.
Here, we uncover a profound dysregulation in the expression of relevant spliceosome-components and splicing-factors in craniopharyngiomas versus control non-tumour tissues, identifying PRPF8 and RAVER1 as key tumour suppressor factors associated with relevant oncogenic pro …
Here, we uncover a profound dysregulation in the expression of relevant spliceosome-components and splicing-factors in craniopharyngiomas ve …
RAVER1 is a coactivator of MDA5-mediated cellular antiviral response.
Chen H, Li Y, Zhang J, Ran Y, Wei J, Yang Y, Shu HB. Chen H, et al. J Mol Cell Biol. 2013 Apr;5(2):111-9. doi: 10.1093/jmcb/mjt006. Epub 2013 Feb 5. J Mol Cell Biol. 2013. PMID: 23390309
Here we identified ribonucleoprotein PTB-binding 1 (RAVER1) as a specific MDA5-interacting protein. RAVER1 was associated with MDA5 upon viral infection. ...Mechanistically, overexpression of RAVER1 enhanced the binding of MDA5 to its ligand poly(I:C), wherea …
Here we identified ribonucleoprotein PTB-binding 1 (RAVER1) as a specific MDA5-interacting protein. RAVER1 was associated with …
Raver1, a dual compartment protein, is a ligand for PTB/hnRNPI and microfilament attachment proteins.
Hüttelmaier S, Illenberger S, Grosheva I, Rüdiger M, Singer RH, Jockusch BM. Hüttelmaier S, et al. J Cell Biol. 2001 Nov 26;155(5):775-86. doi: 10.1083/jcb.200105044. Epub 2001 Nov 26. J Cell Biol. 2001. PMID: 11724819 Free PMC article.
By screening a yeast two-hybrid library with COOH-terminal fragments of vinculin/metavinculin as the bait, we identified a new protein termed raver1. Raver1 is an 80-kD multidomain protein and widely expressed but to varying amounts in different cell lines. ...Durin …
By screening a yeast two-hybrid library with COOH-terminal fragments of vinculin/metavinculin as the bait, we identified a new protein terme …
Raver1 interactions with vinculin and RNA suggest a feed-forward pathway in directing mRNA to focal adhesions.
Lee JH, Rangarajan ES, Yogesha SD, Izard T. Lee JH, et al. Structure. 2009 Jun 10;17(6):833-42. doi: 10.1016/j.str.2009.04.010. Structure. 2009. PMID: 19523901 Free PMC article.
Vinculin links focal adhesions to the actin cytoskeleton following its activation by integrin signaling, which severs intramolecular interactions of vinculin's head and tail (Vt) domains. Our vinculin:raver1 crystal structures and binding studies show that activated Vt sel …
Vinculin links focal adhesions to the actin cytoskeleton following its activation by integrin signaling, which severs intramolecular interac …
The PTB interacting protein raver1 regulates alpha-tropomyosin alternative splicing.
Gromak N, Rideau A, Southby J, Scadden AD, Gooding C, Hüttelmaier S, Singer RH, Smith CW. Gromak N, et al. EMBO J. 2003 Dec 1;22(23):6356-64. doi: 10.1093/emboj/cdg609. EMBO J. 2003. PMID: 14633994 Free PMC article.
Consistent with these interactions raver1 can be localized in either the nucleus or cytoplasm. Here we show that raver1 is able to promote the smooth muscle-specific alternative splicing of TM by enhancing PTB-mediated repression of exon 3. This activity of raver …
Consistent with these interactions raver1 can be localized in either the nucleus or cytoplasm. Here we show that raver1 is abl …
38 results