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170 results

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Page 1
Unveiling RCOR1 as a rheostat at transcriptionally permissive chromatin.
Rivera C, Lee HG, Lappala A, Wang D, Noches V, Olivares-Costa M, Sjöberg-Herrera M, Lee JT, Andrés ME. Rivera C, et al. Nat Commun. 2022 Mar 23;13(1):1550. doi: 10.1038/s41467-022-29261-0. Nat Commun. 2022. PMID: 35322029 Free PMC article.
However, there is currently an incomplete understanding of RCOR1's range of localization and function. Here, we probe RCOR1's distribution on a genome-wide scale and unexpectedly find that RCOR1 is predominantly associated with transcriptionally active genes. …
However, there is currently an incomplete understanding of RCOR1's range of localization and function. Here, we probe RCOR1's …
RCOR1 promotes myoblast differentiation and muscle regeneration.
Pauk M, Wang F, Rummukainen P, Ramm HGM, Taipaleenmäki H, Kiviranta R. Pauk M, et al. Cell Death Discov. 2025 Jul 1;11(1):298. doi: 10.1038/s41420-025-02568-9. Cell Death Discov. 2025. PMID: 40595461 Free PMC article.
Although combined silencing of P21 and RCOR1 rescued the proliferation defect of RCOR1 deficiency alone, it failed to restore differentiation, suggesting that RCOR1 action on myoblast proliferation and differentiation is mediated via independent mechanisms. . …
Although combined silencing of P21 and RCOR1 rescued the proliferation defect of RCOR1 deficiency alone, it failed to restore …
RCOR1 improves neurobehaviors and neuron injury in rat cerebral palsy by Endothelin-1 targeting-induced Akt/GSK-3beta pathway upregulation.
Xu H, Yu X, Xie R, Wang Y, Li C. Xu H, et al. Brain Dev. 2024 Feb;46(2):93-102. doi: 10.1016/j.braindev.2023.11.001. Epub 2023 Nov 17. Brain Dev. 2024. PMID: 37978036
Besides, RCOR1 can interact with Endothelin-1 (EDN1), and EDN1 expression is related to brain damage. ...RESULTS: RCOR1 was low-expressed but EDN1 was high-expressed in CP model rats and OGD/R-treated neurons. ...
Besides, RCOR1 can interact with Endothelin-1 (EDN1), and EDN1 expression is related to brain damage. ...RESULTS: RCOR1 was lo …
RCOR1 is targeted by miR-23b-3p to modulate growth, colony formation, migration, and invasion of prostate cancer cells.
Liu C, Dong Z, Li M, Bai G, Zhao Z. Liu C, et al. Int J Clin Exp Pathol. 2024 Feb 15;17(2):29-38. doi: 10.62347/MNSQ2960. eCollection 2024. Int J Clin Exp Pathol. 2024. PMID: 38455506 Free PMC article.
Bioinformatics analysis identified miR-23b-3p as a potential regulator of RCOR1, and luciferase assays validated RCOR1 as a downstream target of miR-23b-3p. Increasing miR-23b-3p mimics diminished RCOR1's mRNA and protein levels, while raising miR-23b-3p leve …
Bioinformatics analysis identified miR-23b-3p as a potential regulator of RCOR1, and luciferase assays validated RCOR1 as a do …
REST, RCOR1 and RCOR2 expression is reduced in osteoarthritic chondrocytes and contributes to increasing MMP13 and ADAMTS5 expression through upregulating HES1.
Primrose JGB, Jain L, Alhilali M, Bolam SM, Monk AP, Munro JT, Dalbeth N, Poulsen RC. Primrose JGB, et al. Cell Signal. 2023 Sep;109:110800. doi: 10.1016/j.cellsig.2023.110800. Epub 2023 Jul 11. Cell Signal. 2023. PMID: 37442513 Free article.
HES1 is a known REST/RCOR1 target gene and HES1 has been shown to promote MMP13 and ADAMTS5 expression in murine OA chondrocytes. ...Over-expression of either REST, RCOR1 or RCOR2 resulted in reduced HES1 levels in OA chondrocytes whereas knockdown of REST, RCOR1 …
HES1 is a known REST/RCOR1 target gene and HES1 has been shown to promote MMP13 and ADAMTS5 expression in murine OA chondrocytes. ... …
HKDC1 promotes colorectal cancer progression by regulating RCOR1 expression to activate the Wnt/beta-catenin pathway, enhancing proliferation, migration, and epithelial-mesenchymal transition.
Huang S, Pang Q, Zhang Y, Cao J. Huang S, et al. J Biol Chem. 2025 May;301(5):108478. doi: 10.1016/j.jbc.2025.108478. Epub 2025 Apr 8. J Biol Chem. 2025. PMID: 40209953 Free PMC article.
Coimmunoprecipitation, immunofluorescence, and mass spectrometry identified HKDC1's interaction with RCOR1, demonstrating its regulation of the Wnt/beta-catenin pathway to promote CRC progression. ...This study is the first to demonstrate that HKDC1 enhances CRC proliferat …
Coimmunoprecipitation, immunofluorescence, and mass spectrometry identified HKDC1's interaction with RCOR1, demonstrating its regulat …
Corepressor Rcor1 is essential for murine erythropoiesis.
Yao H, Goldman DC, Nechiporuk T, Kawane S, McWeeney SK, Tyner JW, Fan G, Kerenyi MA, Orkin SH, Fleming WH, Mandel G. Yao H, et al. Blood. 2014 May 15;123(20):3175-84. doi: 10.1182/blood-2013-11-538678. Epub 2014 Mar 20. Blood. 2014. PMID: 24652990 Free PMC article.
The corepressor Rcor1 has been linked biochemically to hematopoiesis, but its function in vivo remains unknown. ...The colony-stimulating factor 2 receptor beta subunit (Csf2rb), which codes for a receptor implicated in myeloid cytokine signaling, is a direct target for bo …
The corepressor Rcor1 has been linked biochemically to hematopoiesis, but its function in vivo remains unknown. ...The colony-stimula …
UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex.
Chagraoui J, Girard S, Spinella JF, Simon L, Bonneil E, Mayotte N, MacRae T, Coulombe-Huntington J, Bertomeu T, Moison C, Tomellini E, Thibault P, Tyers M, Marinier A, Sauvageau G. Chagraoui J, et al. Cell Stem Cell. 2021 Jan 7;28(1):48-62.e6. doi: 10.1016/j.stem.2020.12.002. Cell Stem Cell. 2021. PMID: 33417871 Free article.
CRL3(KBTBD4) targets components of the LSD1/RCOR1 corepressor complex for proteasomal degradation, hence re-establishing H3K4me2 and H3K27ac epigenetic marks, which are rapidly decreased upon ex vivo culture of human HSCs....
CRL3(KBTBD4) targets components of the LSD1/RCOR1 corepressor complex for proteasomal degradation, hence re-establishing H3K4me2 and …
RCOR1 directly binds to MED28 and weakens its inducing effect on cancer stem cell-like activity of oral cavity squamous cell carcinoma cells.
Xiang Z, Zhou S, Liang S, Zhang G, Tan Y. Xiang Z, et al. J Oral Pathol Med. 2020 Sep;49(8):741-750. doi: 10.1111/jop.13022. Epub 2020 May 14. J Oral Pathol Med. 2020. PMID: 32306431
Its overexpression partly abrogated MED28-induced expression of CSC markers. RCOR1 expression was associated with promoter hypermethylation, while MED28 expression was positively correlated with its MED28 copy number (Pearson's r = .44) in OCSCC tissues. ...Its overexpress …
Its overexpression partly abrogated MED28-induced expression of CSC markers. RCOR1 expression was associated with promoter hypermethy …
170 results