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Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications.
Kissel T, Reijm S, Slot LM, Cavallari M, Wortel CM, Vergroesen RD, Stoeken-Rijsbergen G, Kwekkeboom JC, Kampstra A, Levarht E, Drijfhout JW, Bang H, Bonger KM, Janssen G, van Veelen PA, Huizinga T, Scherer HU, Reth M, Toes R. Kissel T, et al. Among authors: reijm s. Ann Rheum Dis. 2020 Apr;79(4):472-480. doi: 10.1136/annrheumdis-2019-216499. Epub 2020 Feb 10. Ann Rheum Dis. 2020. PMID: 32041746
Different classes of anti-modified protein antibodies are induced on exposure to antigens expressing only one type of modification.
Kampstra ASB, Dekkers JS, Volkov M, Dorjée AL, Hafkenscheid L, Kempers AC, van Delft M, Kissel T, Reijm S, Janssen GMC, van Veelen PA, Bang H, Huizinga TWJ, Trouw LA, van der Woude D, Toes REM. Kampstra ASB, et al. Among authors: reijm s. Ann Rheum Dis. 2019 Jul;78(7):908-916. doi: 10.1136/annrheumdis-2018-214950. Epub 2019 May 31. Ann Rheum Dis. 2019. PMID: 31151934