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Anti-aging teleconference: what is anti-aging medicine?
Arking R, Butler B, Chiko B, Fossel M, Gavrilov LA, Morley JE, Olshansky SJ, Perls T, Walker RF. Arking R, et al. J Anti Aging Med. 2003;6(2):91-106. doi: 10.1089/109454503769684775. J Anti Aging Med. 2003. PMID: 14614799
The concepts of "anti-aging" and "anti-aging medicine" in particular are hotly debated now, both in the mass media and among some researchers. This paper represents an open discussion of anti-aging terms and related ideas by nine leading experts in the field …
The concepts of "anti-aging" and "anti-aging medicine" in particular are hotly debated now, both in the mass media and among s …
Evolution of longevity improves immunity in Drosophila.
Fabian DK, Garschall K, Klepsatel P, Santos-Matos G, Sucena É, Kapun M, Lemaitre B, Schlötterer C, Arking R, Flatt T. Fabian DK, et al. Among authors: arking r. Evol Lett. 2018 Nov 12;2(6):567-579. doi: 10.1002/evl3.89. eCollection 2018 Dec. Evol Lett. 2018. PMID: 30564440 Free PMC article.
Much has been learned about the genetics of aging from studies in model organisms, but still little is known about naturally occurring alleles that contribute to variation in longevity. ...
Much has been learned about the genetics of aging from studies in model organisms, but still little is known about naturally occurrin …
Genomic plasticity, energy allocations, and the extended longevity phenotypes of Drosophila.
Arking R, Buck S, Novoseltev VN, Hwangbo DS, Lane M. Arking R, et al. Ageing Res Rev. 2002 Apr;1(2):209-28. doi: 10.1016/s1568-1637(01)00010-1. Ageing Res Rev. 2002. PMID: 12039439 Review.
The antagonistic pleiotropy theory of the evolution of aging is shown to be too simple to fully apply to the situation in which Drosophila are selected directly for delayed female fecundity and indirectly for extended longevity. ...
The antagonistic pleiotropy theory of the evolution of aging is shown to be too simple to fully apply to the situation in which Droso …
The human life span is not that limited: the effect of multiple longevity phenotypes.
Arking R, Novoseltsev V, Novoseltseva J. Arking R, et al. J Gerontol A Biol Sci Med Sci. 2004 Jul;59(7):697-704. doi: 10.1093/gerona/59.7.b697. J Gerontol A Biol Sci Med Sci. 2004. PMID: 15304534 Review.
We add our empirical observation that there exist multiple longevity phenotypes, each of which arises from the alteration of fundamental aging processes. The current debate only considers two of the three known mammalian longevity phenotypes. ...
We add our empirical observation that there exist multiple longevity phenotypes, each of which arises from the alteration of fundamental …
Age-related change in γH2AX of Drosophila muscle: its significance as a marker for muscle damage and longevity.
Jeon HJ, Kim YS, Park JS, Pyo JH, Na HJ, Kim IJ, Kim CM, Chung HY, Kim ND, Arking R, Yoo MA. Jeon HJ, et al. Among authors: arking r. Biogerontology. 2015 Aug;16(4):503-16. doi: 10.1007/s10522-015-9573-0. Epub 2015 Apr 10. Biogerontology. 2015. PMID: 25860864
Muscle aging is closely related to unhealthy late-life and organismal aging. ...Thus, understanding how fully differentiated muscle cells age is required for ensuring healthy aging. Adult Drosophila muscle is a useful model for exploring the aging proc …
Muscle aging is closely related to unhealthy late-life and organismal aging. ...Thus, understanding how fully differentiated m …
Increased centrosome amplification in aged stem cells of the Drosophila midgut.
Park JS, Pyo JH, Na HJ, Jeon HJ, Kim YS, Arking R, Yoo MA. Park JS, et al. Among authors: arking r. Biochem Biophys Res Commun. 2014 Jul 25;450(2):961-5. doi: 10.1016/j.bbrc.2014.06.085. Epub 2014 Jun 24. Biochem Biophys Res Commun. 2014. PMID: 24971546 Free article.
Age-related changes in long-lived tissue-resident stem cells may be tightly linked to aging and age-related diseases such as cancer. Centrosomes play key roles in cell proliferation, differentiation and migration. ...Our data show the first direct evidence for the age-rela …
Age-related changes in long-lived tissue-resident stem cells may be tightly linked to aging and age-related diseases such as cancer. …
Chemical regulation of mid- and late-life longevities in Drosophila.
McDonald P, Maizi BM, Arking R. McDonald P, et al. Among authors: arking r. Exp Gerontol. 2013 Feb;48(2):240-9. doi: 10.1016/j.exger.2012.09.006. Epub 2012 Oct 5. Exp Gerontol. 2013. PMID: 23044027 Free PMC article.
These studies may help to shed light on the frailty syndrome affecting some aging organisms....
These studies may help to shed light on the frailty syndrome affecting some aging organisms....
SIN3 is critical for stress resistance and modulates adult lifespan.
Barnes VL, Bhat A, Unnikrishnan A, Heydari AR, Arking R, Pile LA. Barnes VL, et al. Among authors: arking r. Aging (Albany NY). 2014 Aug;6(8):645-60. doi: 10.18632/aging.100684. Aging (Albany NY). 2014. PMID: 25133314 Free PMC article.
Although Sin3A knockdown flies exhibited decreased longevity compared to wild type, no significant changes in expression of many well-categorized aging genes were observed. We found, however, that Sin3A knockdown corresponded to a significant reduction in expression of gen …
Although Sin3A knockdown flies exhibited decreased longevity compared to wild type, no significant changes in expression of many well-catego …
Metformin inhibits age-related centrosome amplification in Drosophila midgut stem cells through AKT/TOR pathway.
Na HJ, Park JS, Pyo JH, Jeon HJ, Kim YS, Arking R, Yoo MA. Na HJ, et al. Among authors: arking r. Mech Ageing Dev. 2015 Jul;149:8-18. doi: 10.1016/j.mad.2015.05.004. Epub 2015 May 16. Mech Ageing Dev. 2015. PMID: 25988874 Free article.
Age-related changes in tissue-resident stem cells may be closely associated with tissue aging and age-related diseases, such as cancer. Centrosome amplification is a hallmark of cancers. ...We propose that the Drosophila ISCs may be an excellent model system for in vivo st …
Age-related changes in tissue-resident stem cells may be closely associated with tissue aging and age-related diseases, such as cance …
The Digital Ageing Atlas: integrating the diversity of age-related changes into a unified resource.
Craig T, Smelick C, Tacutu R, Wuttke D, Wood SH, Stanley H, Janssens G, Savitskaya E, Moskalev A, Arking R, de Magalhães JP. Craig T, et al. Among authors: arking r. Nucleic Acids Res. 2015 Jan;43(Database issue):D873-8. doi: 10.1093/nar/gku843. Epub 2014 Sep 17. Nucleic Acids Res. 2015. PMID: 25232097 Free PMC article.
Multiple studies characterizing the human ageing phenotype have been conducted for decades. However, there is no centralized resource in which data on multiple age-related changes are collated. ...To address this and facilitate integrative, system-level studies of agein
Multiple studies characterizing the human ageing phenotype have been conducted for decades. However, there is no centralized resource …
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