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Targeting mitochondria-derived reactive oxygen species to reduce epithelial barrier dysfunction and colitis.
Wang A, Keita ÅV, Phan V, McKay CM, Schoultz I, Lee J, Murphy MP, Fernando M, Ronaghan N, Balce D, Yates R, Dicay M, Beck PL, MacNaughton WK, Söderholm JD, McKay DM. Wang A, et al. Among authors: ronaghan n. Am J Pathol. 2014 Sep;184(9):2516-27. doi: 10.1016/j.ajpath.2014.05.019. Epub 2014 Jul 14. Am J Pathol. 2014. PMID: 25034594 Free PMC article.
The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction.
Ronaghan NJ, Shang J, Iablokov V, Zaheer R, Colarusso P, Dion S, Désilets A, Leduc R, Turner JR, MacNaughton WK. Ronaghan NJ, et al. Am J Physiol Gastrointest Liver Physiol. 2016 Sep 1;311(3):G466-79. doi: 10.1152/ajpgi.00441.2015. Epub 2016 Aug 4. Am J Physiol Gastrointest Liver Physiol. 2016. PMID: 27492333 Free PMC article.