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133 results

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Page 1
Roles of retrovirus-derived PEG10 and PEG11/RTL1 in mammalian development and evolution and their involvement in human disease.
Shiura H, Kitazawa M, Ishino F, Kaneko-Ishino T. Shiura H, et al. Front Cell Dev Biol. 2023 Sep 29;11:1273638. doi: 10.3389/fcell.2023.1273638. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 37842090 Free PMC article. Review.
PEG10 and PEG11/RTL1 are paternally expressed, imprinted genes that play essential roles in the current eutherian developmental system and are therefore associated with developmental abnormalities caused by aberrant genomic imprinting. ...In this manuscript, we review the …
PEG10 and PEG11/RTL1 are paternally expressed, imprinted genes that play essential roles in the current eutherian developmental syste …
RTL1/PEG11 imprinted in human and mouse brain mediates anxiety-like and social behaviors and regulates neuronal excitability in the locus coeruleus.
Chou MY, Hu MC, Chen PY, Hsu CL, Lin TY, Tan MJ, Lee CY, Kuo MF, Huang PH, Wu VC, Yang SH, Fan PC, Huang HY, Akbarian S, Loo TH, Stewart CL, Huang HP, Gau SS, Huang HS. Chou MY, et al. Hum Mol Genet. 2022 Sep 10;31(18):3161-3180. doi: 10.1093/hmg/ddac110. Hum Mol Genet. 2022. PMID: 35567414 Free PMC article.
RTL1/PEG11, which has been associated with anxiety disorders, is a retrotransposon-derived imprinted gene in the placenta. However, imprinting patterns and functions of RTL1 in the brain have not been well-investigated. We found Rtl1 was paternally, but not m …
RTL1/PEG11, which has been associated with anxiety disorders, is a retrotransposon-derived imprinted gene in the placenta. However, i …
Expression profiling of RTL1 in human breast cancer tissues and cell lines.
Mahmoudi AR, Ghods R, Madjd Z, Abolhasani M, Saeednejad Zanjani L, Safaei M, Balaei Goli L, Vafaei S, Katouzian L, Soltanghoraei H, Shekarabi M, Zarnani AH. Mahmoudi AR, et al. Exp Mol Pathol. 2021 Aug;121:104654. doi: 10.1016/j.yexmp.2021.104654. Epub 2021 Jun 1. Exp Mol Pathol. 2021. PMID: 34087231
Here we investigated the expression of a placenta-specific protein, Retrotransposon-like 1 (RTL1) in a series of BC tissues and cell lines. RTL1-specific polyclonal antibody was generated and characterized. ...All cell lines expressed RTL1 with varying degree …
Here we investigated the expression of a placenta-specific protein, Retrotransposon-like 1 (RTL1) in a series of BC tissues and cell …
RTL1 promotes melanoma proliferation by regulating Wnt/beta-catenin signalling.
Fan G, Ye D, Zhu S, Xi J, Guo X, Qiao J, Wu Y, Jia W, Wang G, Fan G, Kang J. Fan G, et al. Oncotarget. 2017 Nov 20;8(62):106026-106037. doi: 10.18632/oncotarget.22523. eCollection 2017 Dec 1. Oncotarget. 2017. PMID: 29285312 Free PMC article.
Here, we found that retrotransposon-like 1 (RTL1) is highly enriched in melanoma tissue, especially in early and horizontal growth tissues. ...Together, our results demonstrated that RTL1 promotes melanoma cell proliferation by regulating the Wnt/beta-Catenin signal …
Here, we found that retrotransposon-like 1 (RTL1) is highly enriched in melanoma tissue, especially in early and horizontal growth ti …
Temple syndrome and Kagami-Ogata syndrome: clinical presentations, genotypes, models and mechanisms.
Prasasya R, Grotheer KV, Siracusa LD, Bartolomei MS. Prasasya R, et al. Hum Mol Genet. 2020 Sep 30;29(R1):R107-R116. doi: 10.1093/hmg/ddaa133. Hum Mol Genet. 2020. PMID: 32592473 Free PMC article. Review.
The locus encompasses paternally expressed protein-coding genes (DLK1, RTL1 and DIO3) and maternally expressed lncRNAs (MEG3/GTL2, RTL1as and MEG8), as well as numerous miRNAs and snoRNAs. ...
The locus encompasses paternally expressed protein-coding genes (DLK1, RTL1 and DIO3) and maternally expressed lncRNAs (MEG3/GTL2, RT …
The role of eutherian-specific RTL1 in the nervous system and its implications for the Kagami-Ogata and Temple syndromes.
Kitazawa M, Sutani A, Kaneko-Ishino T, Ishino F. Kitazawa M, et al. Genes Cells. 2021 Mar;26(3):165-179. doi: 10.1111/gtc.12830. Epub 2021 Feb 16. Genes Cells. 2021. PMID: 33484574 Free PMC article.
Here, we demonstrate that the mouse RTL1 protein is widely expressed in the central nervous system (CNS), including the limbic system. Importantly, two disease model mice with over- and under-expression of Rtl1 exhibited reduced locomotor activity, increased anxiety …
Here, we demonstrate that the mouse RTL1 protein is widely expressed in the central nervous system (CNS), including the limbic system …
Discovery of a novel marker for human granulocytes and tissue macrophages: RTL1 revisited.
Mortezagholi S, Mahmoudi AR, Shojaeian S, Vafaei S, Soltanghoraei H, Bayat AA, Shokri F, Ghods R, Zarnani AH. Mortezagholi S, et al. Cell Tissue Res. 2023 Oct;394(1):177-188. doi: 10.1007/s00441-023-03817-y. Epub 2023 Aug 3. Cell Tissue Res. 2023. PMID: 37535101
Serial sections of the appendix stained with CD15 and RTL1 and placenta stained with CD68 and RTL1 showed a considerable overlap in RTL1 expression in CD15(+) granulocytes and CD68(+) macrophages. ...Endothelial cells of normal and cancer tissues highly expre …
Serial sections of the appendix stained with CD15 and RTL1 and placenta stained with CD68 and RTL1 showed a considerable overl …
Retrotransposon gag-like 1 (RTL1) and the molecular evolution of self-targeting imprinted microRNAs.
Mainieri A, Haig D. Mainieri A, et al. Biol Direct. 2019 Oct 22;14(1):18. doi: 10.1186/s13062-019-0250-0. Biol Direct. 2019. PMID: 31640745 Free PMC article.
BACKGROUND: Transcription of the antisense strand of RTL1 produces a sense mRNA that is targeted for degradation by antisense microRNAs transcribed from the sense strand. ...We present an evolutionary model for the establishment of a new self-targeting microRNA derived fro …
BACKGROUND: Transcription of the antisense strand of RTL1 produces a sense mRNA that is targeted for degradation by antisense microRN …
DNA methylation of the Rtl1 promoter in the placentas with fetal growth restriction.
Fujioka K, Nishida K, Ashina M, Abe S, Fukushima S, Ikuta T, Ohyama S, Morioka I, Iijima K. Fujioka K, et al. Pediatr Neonatol. 2019 Oct;60(5):512-516. doi: 10.1016/j.pedneo.2019.01.001. Epub 2019 Jan 5. Pediatr Neonatol. 2019. PMID: 30679037 Free article.
An imprinted gene encoding retrotransposon-like protein 1 (RTL1) is regulated by DNA methylation in the promoter region and plays a key role in placental development. ...CONCLUSION: Infants with severe SGA have abnormal placental DNA methylation of CpG1 in the CG4 region o …
An imprinted gene encoding retrotransposon-like protein 1 (RTL1) is regulated by DNA methylation in the promoter region and plays a k …
Paternally expressed retrotransposon Gag-like 1 gene, RTL1, is one of the crucial elements for placental angiogenesis in horses.
Dini P, Carossino M, Balasuriya UBR, El-Sheikh Ali H, Loux SC, Esteller-Vico A, Scoggin KE, Loynachan AT, Kalbfleisch T, De Spiegelaere W, Daels P, Ball BA. Dini P, et al. Biol Reprod. 2021 Jun 4;104(6):1386-1399. doi: 10.1093/biolre/ioab039. Biol Reprod. 2021. PMID: 33693478
RTL1 (retrotransposon Gag-like 1) is an essential gene in the development of the human and murine placenta. Several fetal and placental abnormalities such as intrauterine growth restriction (IUGR) and hydrops conditions have been associated with altered expression of this …
RTL1 (retrotransposon Gag-like 1) is an essential gene in the development of the human and murine placenta. Several fetal and placent …
133 results