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Combined MEK and Pi3'-kinase inhibition reveals synergy in targeting thyroid cancer in vitro and in vivo.

ElMokh O, Ruffieux-Daidié D, Roelli MA, Stooss A, Phillips WA, Gertsch J, Dettmer MS, Charles RP. ElMokh O, et al. Among authors: ruffieux daidie d. Oncotarget. 2017 Apr 11;8(15):24604-24620. doi: 10.18632/oncotarget.15599. Oncotarget. 2017. PMID: 28445948 Free PMC article.

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Deubiquitylation regulates activation and proteolytic cleavage of ENaC.

Ruffieux-Daidié D, Poirot O, Boulkroun S, Verrey F, Kellenberger S, Staub O. Ruffieux-Daidié D, et al. J Am Soc Nephrol. 2008 Nov;19(11):2170-80. doi: 10.1681/ASN.2007101130. Epub 2008 Aug 13. J Am Soc Nephrol. 2008. PMID: 18701608 Free PMC article.

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PIK3CA^H1047R-induced paradoxical ERK activation results in resistance to BRAF^V600E specific inhibitors in BRAF^V600E PIK3CA^H1047R double mutant thyroid tumors.

Roelli MA, Ruffieux-Daidié D, Stooss A, ElMokh O, Phillips WA, Dettmer MS, Charles RP. Roelli MA, et al. Among authors: ruffieux daidie d. Oncotarget. 2017 Oct 11;8(61):103207-103222. doi: 10.18632/oncotarget.21732. eCollection 2017 Nov 28. Oncotarget. 2017. PMID: 29262556 Free PMC article.

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Ubiquitin-specific protease 2-45 (Usp2-45) binds to epithelial Na+ channel (ENaC)-ubiquitylating enzyme Nedd4-2.

Oberfeld B, Ruffieux-Daidié D, Vitagliano JJ, Pos KM, Verrey F, Staub O. Oberfeld B, et al. Among authors: ruffieux daidie d. Am J Physiol Renal Physiol. 2011 Jul;301(1):F189-96. doi: 10.1152/ajprenal.00487.2010. Epub 2011 Apr 6. Am J Physiol Renal Physiol. 2011. PMID: 21478478 Free article.

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Mice carrying ubiquitin-specific protease 2 (Usp2) gene inactivation maintain normal sodium balance and blood pressure.

Pouly D, Debonneville A, Ruffieux-Daidié D, Maillard M, Abriel H, Loffing J, Staub O. Pouly D, et al. Among authors: ruffieux daidie d. Am J Physiol Renal Physiol. 2013 Jul 1;305(1):F21-30. doi: 10.1152/ajprenal.00012.2013. Epub 2013 Apr 3. Am J Physiol Renal Physiol. 2013. PMID: 23552861 Free article.

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Intracellular ubiquitylation of the epithelial Na+ channel controls extracellular proteolytic channel activation via conformational change.

Ruffieux-Daidié D, Staub O. Ruffieux-Daidié D, et al. J Biol Chem. 2011 Jan 28;286(4):2416-24. doi: 10.1074/jbc.M110.176156. Epub 2010 Nov 17. J Biol Chem. 2011. PMID: 21084303 Free PMC article.

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Mineralocorticoid receptor degradation is promoted by Hsp90 inhibition and the ubiquitin-protein ligase CHIP.

Faresse N, Ruffieux-Daidie D, Salamin M, Gomez-Sanchez CE, Staub O. Faresse N, et al. Among authors: ruffieux daidie d. Am J Physiol Renal Physiol. 2010 Dec;299(6):F1462-72. doi: 10.1152/ajprenal.00285.2010. Epub 2010 Sep 22. Am J Physiol Renal Physiol. 2010. PMID: 20861078 Free article.

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Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3.

Boulkroun S, Ruffieux-Daidié D, Vitagliano JJ, Poirot O, Charles RP, Lagnaz D, Firsov D, Kellenberger S, Staub O. Boulkroun S, et al. Among authors: ruffieux daidie d. Am J Physiol Renal Physiol. 2008 Oct;295(4):F889-900. doi: 10.1152/ajprenal.00001.2008. Epub 2008 Jul 16. Am J Physiol Renal Physiol. 2008. PMID: 18632802 Free article.

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Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway.

Arroyo JP, Lagnaz D, Ronzaud C, Vázquez N, Ko BS, Moddes L, Ruffieux-Daidié D, Hausel P, Koesters R, Yang B, Stokes JB, Hoover RS, Gamba G, Staub O. Arroyo JP, et al. Among authors: ruffieux daidie d. J Am Soc Nephrol. 2011 Sep;22(9):1707-19. doi: 10.1681/ASN.2011020132. Epub 2011 Aug 18. J Am Soc Nephrol. 2011. PMID: 21852580 Free PMC article.

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