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Potential and limitations of PKA/ PKG inhibitors for platelet studies.

Shpakova V, Rukoyatkina N, Walter U, Gambaryan S. Shpakova V, et al. Among authors: rukoyatkina n. Platelets. 2021 Nov 30:1-10. doi: 10.1080/09537104.2021.2003316. Online ahead of print. Platelets. 2021. PMID: 34845961

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Curcumin at Low Doses Potentiates and at High Doses Inhibits ABT-737-Induced Platelet Apoptosis.

Rukoyatkina N, Shpakova V, Sudnitsyna J, Panteleev M, Makhoul S, Gambaryan S, Jurk K. Rukoyatkina N, et al. Int J Mol Sci. 2021 May 20;22(10):5405. doi: 10.3390/ijms22105405. Int J Mol Sci. 2021. PMID: 34065600 Free PMC article.

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Multifaceted effects of arachidonic acid and interaction with cyclic nucleotides in human platelets.

Rukoyatkina N, Shpakova V, Panteleev M, Kharazova A, Gambaryan S, Geiger J. Rukoyatkina N, et al. Thromb Res. 2018 Nov;171:22-30. doi: 10.1016/j.thromres.2018.09.047. Epub 2018 Sep 13. Thromb Res. 2018. PMID: 30240944

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ML355 Modulates Platelet Activation and Prevents ABT-737 Induced Apoptosis in Platelets.

Shpakova V, Rukoyatkina N, Al Arawe N, Prilepskaya A, Kharazova A, Sharina I, Gambaryan S, Martin E. Shpakova V, et al. Among authors: rukoyatkina n. J Pharmacol Exp Ther. 2022 May;381(2):164-175. doi: 10.1124/jpet.121.000973. Epub 2022 Feb 23. J Pharmacol Exp Ther. 2022. PMID: 35197320 Free PMC article.

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PTH1R Mutants Found in Patients with Primary Failure of Tooth Eruption Disrupt G-Protein Signaling.

Subramanian H, Döring F, Kollert S, Rukoyatkina N, Sturm J, Gambaryan S, Stellzig-Eisenhauer A, Meyer-Marcotty P, Eigenthaler M, Wischmeyer E. Subramanian H, et al. Among authors: rukoyatkina n. PLoS One. 2016 Nov 29;11(11):e0167033. doi: 10.1371/journal.pone.0167033. eCollection 2016. PLoS One. 2016. PMID: 27898723 Free PMC article.

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Curcumin by activation of adenosine A_2A receptor stimulates protein kinase a and potentiates inhibitory effect of cangrelor on platelets.

Rukoyatkina N, Shpakova V, Bogoutdinova A, Kharazova A, Mindukshev I, Gambaryan S. Rukoyatkina N, et al. Biochem Biophys Res Commun. 2022 Jan 1;586:20-26. doi: 10.1016/j.bbrc.2021.11.006. Epub 2021 Nov 4. Biochem Biophys Res Commun. 2022. PMID: 34823218

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Erythrocytes do not activate purified and platelet soluble guanylate cyclases even in conditions favourable for NO synthesis.

Gambaryan S, Subramanian H, Kehrer L, Mindukshev I, Sudnitsyna J, Reiss C, Rukoyatkina N, Friebe A, Sharina I, Martin E, Walter U. Gambaryan S, et al. Among authors: rukoyatkina n. Cell Commun Signal. 2016 Aug 11;14(1):16. doi: 10.1186/s12964-016-0139-9. Cell Commun Signal. 2016. PMID: 27515066 Free PMC article.

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The oligopeptide DT-2 is a specific PKG I inhibitor only in vitro, not in living cells.

Gambaryan S, Butt E, Kobsar A, Geiger J, Rukoyatkina N, Parnova R, Nikolaev VO, Walter U. Gambaryan S, et al. Among authors: rukoyatkina n. Br J Pharmacol. 2012 Oct;167(4):826-38. doi: 10.1111/j.1476-5381.2012.02044.x. Br J Pharmacol. 2012. PMID: 22612416 Free PMC article.

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The fibrate gemfibrozil is a NO- and haem-independent activator of soluble guanylyl cyclase: in vitro studies.

Sharina IG, Sobolevsky M, Papakyriakou A, Rukoyatkina N, Spyroulias GA, Gambaryan S, Martin E. Sharina IG, et al. Among authors: rukoyatkina n. Br J Pharmacol. 2015 May;172(9):2316-29. doi: 10.1111/bph.13055. Epub 2015 Feb 10. Br J Pharmacol. 2015. PMID: 25536881 Free PMC article.

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Protein kinase A activation by the anti-cancer drugs ABT-737 and thymoquinone is caspase-3-dependent and correlates with platelet inhibition and apoptosis.

Rukoyatkina N, Butt E, Subramanian H, Nikolaev VO, Mindukshev I, Walter U, Gambaryan S, Benz PM. Rukoyatkina N, et al. Cell Death Dis. 2017 Jun 29;8(6):e2898. doi: 10.1038/cddis.2017.290. Cell Death Dis. 2017. PMID: 28661475 Free PMC article.

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