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The molecular dissection of TRIM25's RNA-binding mechanism provides key insights into its antiviral activity.
Álvarez L, Haubrich K, Iselin L, Gillioz L, Ruscica V, Lapouge K, Augsten S, Huppertz I, Choudhury NR, Simon B, Masiewicz P, Lethier M, Cusack S, Rittinger K, Gabel F, Leitner A, Michlewski G, Hentze MW, Allain FHT, Castello A, Hennig J. Álvarez L, et al. Among authors: ruscica v. Nat Commun. 2024 Oct 1;15(1):8485. doi: 10.1038/s41467-024-52918-x. Nat Commun. 2024. PMID: 39353916 Free PMC article.
Mitochondrial double-stranded RNA homeostasis depends on cell-cycle progression.
Xavier V, Martinelli S, Corbyn R, Pennie R, Rakovic K, Powley IR, Officer-Jones L, Ruscica V, Galloway A, Carlin LM, Cowling VH, Le Quesne J, Martinou JC, MacVicar T. Xavier V, et al. Among authors: ruscica v. Life Sci Alliance. 2024 Aug 29;7(11):e202402764. doi: 10.26508/lsa.202402764. Print 2024 Nov. Life Sci Alliance. 2024. PMID: 39209534 Free PMC article.
Alphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles.
Kamel W, Ruscica V, Embarc-Buh A, de Laurent ZR, Garcia-Moreno M, Demyanenko Y, Orton RJ, Noerenberg M, Madhusudhan M, Iselin L, Järvelin AI, Hannan M, Kitano E, Moore S, Merits A, Davis I, Mohammed S, Castello A. Kamel W, et al. Among authors: ruscica v. Mol Cell. 2024 Dec 19;84(24):4896-4911.e7. doi: 10.1016/j.molcel.2024.11.015. Epub 2024 Dec 11. Mol Cell. 2024. PMID: 39642884 Free article.
HELZ directly interacts with CCR4-NOT and causes decay of bound mRNAs.
Hanet A, Räsch F, Weber R, Ruscica V, Fauser M, Raisch T, Kuzuoğlu-Öztürk D, Chang CT, Bhandari D, Igreja C, Wohlbold L. Hanet A, et al. Among authors: ruscica v. Life Sci Alliance. 2019 Sep 30;2(5):e201900405. doi: 10.26508/lsa.201900405. Print 2019 Oct. Life Sci Alliance. 2019. PMID: 31570513 Free PMC article.
Chk2 and REGγ-dependent DBC1 regulation in DNA damage induced apoptosis.
Magni M, Ruscica V, Buscemi G, Kim JE, Nachimuthu BT, Fontanella E, Delia D, Zannini L. Magni M, et al. Among authors: ruscica v. Nucleic Acids Res. 2014 Dec 1;42(21):13150-60. doi: 10.1093/nar/gku1065. Epub 2014 Oct 31. Nucleic Acids Res. 2014. PMID: 25361978 Free PMC article.