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1985 2
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8,473 results

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Page 1
RYR2-ryanodinopathies: from calcium overload to calcium deficiency.
Steinberg C, Roston TM, van der Werf C, Sanatani S, Chen SRW, Wilde AAM, Krahn AD. Steinberg C, et al. Europace. 2023 Jun 2;25(6):euad156. doi: 10.1093/europace/euad156. Europace. 2023. PMID: 37387319 Free PMC article.
The sarcoplasmatic reticulum (SR) cardiac ryanodine receptor/calcium release channel RyR2 is an essential regulator of cardiac excitation-contraction coupling and intracellular calcium homeostasis. ...The pathophysiology of the dif …
The sarcoplasmatic reticulum (SR) cardiac ryanodine receptor/calcium release channel RyR2 is an es …
[RyR2 mutation-linked arrhythmogenic diseases and its therapeutic strategies].
Kurebayashi N, Murayama T. Kurebayashi N, et al. Nihon Yakurigaku Zasshi. 2020;155(4):225-229. doi: 10.1254/fpj.20017. Nihon Yakurigaku Zasshi. 2020. PMID: 32612034 Review. Japanese.
The type 2 ryanodine receptor (RyR2) is a sarcoplasmic reticulum Ca(2+) release channel that plays a central role in cardiac excitation-contraction coupling. ...At present, the total number of disease-associated RyR2 mutations exceeds 300 …
The type 2 ryanodine receptor (RyR2) is a sarcoplasmic reticulum Ca(2+) release channel that plays a cent …
RyR2 Gain-of-Function and Not So Sudden Cardiac Death.
Hamilton S, Terentyev D. Hamilton S, et al. Circ Res. 2021 Jul 23;129(3):417-419. doi: 10.1161/CIRCRESAHA.121.319651. Epub 2021 Jul 22. Circ Res. 2021. PMID: 34292783 Free PMC article. No abstract available.
"Ryanopathies" and RyR2 dysfunctions: can we further decipher them using in vitro human disease models?
Sleiman Y, Lacampagne A, Meli AC. Sleiman Y, et al. Cell Death Dis. 2021 Nov 1;12(11):1041. doi: 10.1038/s41419-021-04337-9. Cell Death Dis. 2021. PMID: 34725342 Free PMC article. Review.
The ryanodine receptor (RyR), the largest intracellular calcium release channel located on the sarco/endoplasmic reticulum (SR/ER), plays a key role in the intracellular Ca(2+) handling. Abnormal type 2 ryanodine receptor (RyR2 …
The ryanodine receptor (RyR), the largest intracellular calcium release channel located on the sarco/endo …
RyR2 Binding of an Antiarrhythmic Cyclic Depsipeptide Mapped Using Confocal Fluorescence Lifetime Detection of FRET.
Šeflová J, Schwarz JA, Smith AN, Svensson B, Blackwell DJ, Phillips TA, Nikolaienko R, Bovo E, Rebbeck RT, Zima AV, Thomas DD, Van Petegem F, Knollmann BC, Johnston JN, Robia SL, Cornea RL. Šeflová J, et al. ACS Chem Biol. 2023 Oct 20;18(10):2290-2299. doi: 10.1021/acschembio.3c00376. Epub 2023 Sep 28. ACS Chem Biol. 2023. PMID: 37769131
Hyperactivity of cardiac sarcoplasmic reticulum (SR) ryanodine receptor (RyR2) Ca(2+)-release channels contributes to heart failure and arrhythmias. Reducing the RyR2 activity, particularly during cardiac relaxation (diastole), is a desirable th …
Hyperactivity of cardiac sarcoplasmic reticulum (SR) ryanodine receptor (RyR2) Ca(2+)-release channels contribut …
RyR2-dependent modulation of neuronal hyperactivity: A potential therapeutic target for treating Alzheimer's disease.
Yao J, Chen SRW. Yao J, et al. J Physiol. 2024 Apr;602(8):1509-1518. doi: 10.1113/JP283824. Epub 2023 Mar 14. J Physiol. 2024. PMID: 36866974 Review.
In support of this, it has recently been shown that genetically and pharmacologically limiting ryanodine receptor 2 (RyR2) open time prevents neuronal hyperactivity, memory impairment, dendritic spine loss and neuronal cell death in AD mouse models. ...Thus, …
In support of this, it has recently been shown that genetically and pharmacologically limiting ryanodine receptor 2 (RyR2 …
Calcium Signaling Consequences of RyR2-S4938F Mutation Expressed in Human iPSC-Derived Cardiomyocytes.
Toth N, Zhang XH, Zamaro A, Morad M. Toth N, et al. Int J Mol Sci. 2023 Oct 18;24(20):15307. doi: 10.3390/ijms242015307. Int J Mol Sci. 2023. PMID: 37894987 Free PMC article.
Type-2 ryanodine receptor (RyR2) is the major Ca(2+) release channel of the cardiac sarcoplasmic reticulum (SR) that controls the rhythm and strength of the heartbeat, but its malfunction may generate severe arrhythmia leading to sudden cardiac …
Type-2 ryanodine receptor (RyR2) is the major Ca(2+) release channel of the cardiac sarcoplasmic reticulu …
RyR2 C-terminal truncating variants identified in patients with arrhythmic phenotypes exert a dominant negative effect through formation of wildtype-truncation heteromers.
Tian S, Zhong X, Wang H, Wei J, Guo W, Wang R, Paul Estillore J, Napolitano C, Duff HH, Ilhan E, Knight LM, Lloyd MS, Roberts JD, Priori SG, Chen SRW. Tian S, et al. Biochem J. 2023 Sep 13;480(17):1379-1395. doi: 10.1042/BCJ20230254. Biochem J. 2023. PMID: 37492947
Gain-of-function missense variants in the cardiac ryanodine receptor (RyR2) are linked to catecholaminergic polymorphic ventricular tachycardia (CPVT), whereas RyR2 loss-of-function missense variants cause Ca2+ release deficiency syndrome (CRDS) …
Gain-of-function missense variants in the cardiac ryanodine receptor (RyR2) are linked to catecholaminergic polymorphic …
RyR2 phosphorylation alters dyad architecture.
Short B. Short B. J Gen Physiol. 2024 Apr 1;156(4):e202413569. doi: 10.1085/jgp.202413569. Epub 2024 Mar 7. J Gen Physiol. 2024. PMID: 38451203 Free PMC article.
Physiol.https://doi.org/10.1085/jgp.202213108) indicates that beta-adrenergic signaling enlarges dyads and reorganizes RyR2 tetramers in cardiomyocytes....
Physiol.https://doi.org/10.1085/jgp.202213108) indicates that beta-adrenergic signaling enlarges dyads and reorganizes RyR2 tetramers …
8,473 results